Discovery and Characterization of Pyridoxal 5′-Phosphate-Dependent Cycloleucine Synthases

Pyridoxal 5′-phosphate (PLP)-dependent enzymes are the most versatile biocatalysts for synthesizing nonproteinogenic amino acids. α,α-Disubstituted quaternary amino acids, such as 1-aminocyclopentane-1-carboxylic acid (cycloleucine), are useful building blocks for pharmaceuticals. In this study, sta...

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Veröffentlicht in:	Journal of the American Chemical Society 2024-05, Vol.146 (21), p.14672-14684
Hauptverfasser:	Abad, Abner N. D., Seshadri, Kaushik, Ohashi, Masao, Delgadillo, David A., de Moraes, Lygia S., Nagasawa, Kyle K., Liu, Mengting, Johnson, Samuel, Nelson, Hosea M., Tang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Biocatalysis biosynthesis Cyclopentanes - chemistry Cyclopentanes - metabolism drugs enamines family Lewis acids Lewis bases Molecular Structure pyridoxal Pyridoxal Phosphate - chemistry Pyridoxal Phosphate - metabolism
Online-Zugang:	Volltext
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