How Fungi Biosynthesize 3‑Nitropropanoic Acid: The Simplest yet Lethal Mycotoxin

How Fungi Biosynthesize 3‑Nitropropanoic Acid: The Simplest yet Lethal Mycotoxin

We uncovered the biosynthetic pathway of the lethal mycotoxin 3-nitropropanoic acid (3-NPA) from koji mold Aspergillus oryzae. The biosynthetic gene cluster (BGC) of 3-NPA, which encodes an amine oxidase and a decarboxylase, is conserved in many fungi used in food processing, although most of the st...

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Veröffentlicht in:Organic letters 2024-04, Vol.26 (15), p.3158-3163
Hauptverfasser: Johnson, Colin W., Ohashi, Masao, Tang, Yi
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Ohashi, Masao
Tang, Yi
description We uncovered the biosynthetic pathway of the lethal mycotoxin 3-nitropropanoic acid (3-NPA) from koji mold Aspergillus oryzae. The biosynthetic gene cluster (BGC) of 3-NPA, which encodes an amine oxidase and a decarboxylase, is conserved in many fungi used in food processing, although most of the strains have not been reported to produce 3-NPA. Our discovery will lead to efforts that improve the safety profiles of these indispensable microorganisms in making food, alcoholic beverages, and seasoning.
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title How Fungi Biosynthesize 3‑Nitropropanoic Acid: The Simplest yet Lethal Mycotoxin
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