Effect of vitamin C and hawthorn beverage formula on blood pressure and oxidative stress in heat-exposed workers: a cluster-randomized controlled trial
Background and Objectives: There is no evidence on antioxidant-rich diets in preventing hypertension in heat- exposed workers. We aimed to evaluate the effects of formula supplemented with vitamin C (Vit C) and hawthorn beverage on reducing blood pressure (BP) and oxidative stress levels in heat-exp...
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| Veröffentlicht in: | Asia Pacific Journal of Clinical Nutrition 2024-12, Vol.33 (4), p.503-514 |
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| creator | Du, Wei Zhang, Shuhan Yang, Jiajia Fan, Hongmin |
| description | Background and Objectives: There is no evidence on antioxidant-rich diets in preventing hypertension in heat- exposed workers. We aimed to evaluate the effects of formula supplemented with vitamin C (Vit C) and hawthorn beverage on reducing blood pressure (BP) and oxidative stress levels in heat-exposed workers. Methods and Study Design: In the 40-day cluster-randomized controlled trial, four heat-exposed shift-teams were en- rolled and randomly assigned to the intervention and control groups. The intervention group was given one Vit C tablet (130 mg) and a 500 mL hawthorn beverage containing 278.7 mg flavonoids daily whereas the control group was given 500 mL of slightly salted water daily; both groups were provided education on a healthy diet. BP and creatinine-corrected urinary 8-isoprostane-prostaglandin F2alpha (8-iso-PGF2alpha/Cr) concentrations were assessed at baseline, Day 17 (only BP) and Day 41, respectively. Results: Compared with the control group, the systolic BP (SBP), diastolic BP (DBP), and log10-transformed 8-iso-PGF2alpha/Cr in the intervention group decreased by 7.41 mmHg, 7.93 mmHg and 0.232, respectively, from baseline to day 41 (all p |
| doi_str_mv | 10.6133/apjcn.202412_33(4).0005 |
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We aimed to evaluate the effects of formula supplemented with vitamin C (Vit C) and hawthorn beverage on reducing blood pressure (BP) and oxidative stress levels in heat-exposed workers. Methods and Study Design: In the 40-day cluster-randomized controlled trial, four heat-exposed shift-teams were en- rolled and randomly assigned to the intervention and control groups. The intervention group was given one Vit C tablet (130 mg) and a 500 mL hawthorn beverage containing 278.7 mg flavonoids daily whereas the control group was given 500 mL of slightly salted water daily; both groups were provided education on a healthy diet. BP and creatinine-corrected urinary 8-isoprostane-prostaglandin F2alpha (8-iso-PGF2alpha/Cr) concentrations were assessed at baseline, Day 17 (only BP) and Day 41, respectively. Results: Compared with the control group, the systolic BP (SBP), diastolic BP (DBP), and log10-transformed 8-iso-PGF2alpha/Cr in the intervention group decreased by 7.41 mmHg, 7.93 mmHg and 0.232, respectively, from baseline to day 41 (all p<0.05). When comparing BP levels at baseline, DBP in the intervention group was reduced by 5.46 mmHg when compared to control (p<0.05) among participants with lower baseline BP; SBP and DBP experienced reductions of 9.74 and 9.22 mmHg among participants with higher baseline BP (both p<0.05). Conclusions: Supplementation of Vit C and flavonoids rich hawthorn beverage to heat-exposed workers prevented elevated BP caused by heat exposure which May be attributed to its oxidative stress inhibition effects.</description><identifier>ISSN: 0964-7058</identifier><identifier>ISSN: 1440-6047</identifier><identifier>EISSN: 1440-6047</identifier><identifier>DOI: 10.6133/apjcn.202412_33(4).0005</identifier><identifier>PMID: 39209360</identifier><language>eng</language><publisher>Clayton, Vic: HEC Press</publisher><subject>Adult ; Antioxidants - administration & dosage ; Antioxidants - pharmacology ; Ascorbic Acid - administration & dosage ; Ascorbic Acid - pharmacology ; Beverages ; Blood pressure ; Blood Pressure - drug effects ; Clinical trials ; Crataegus - chemistry ; Dietary Supplements ; Evaluation ; Female ; Flavonoids ; Hot Temperature ; Humans ; Hypertension - prevention & control ; Male ; Middle Aged ; Original ; Oxidative Stress - drug effects ; Vitamin C</subject><ispartof>Asia Pacific Journal of Clinical Nutrition, 2024-12, Vol.33 (4), p.503-514</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389814/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389814/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39209360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Wei</creatorcontrib><creatorcontrib>Zhang, Shuhan</creatorcontrib><creatorcontrib>Yang, Jiajia</creatorcontrib><creatorcontrib>Fan, Hongmin</creatorcontrib><title>Effect of vitamin C and hawthorn beverage formula on blood pressure and oxidative stress in heat-exposed workers: a cluster-randomized controlled trial</title><title>Asia Pacific Journal of Clinical Nutrition</title><addtitle>Asia Pac J Clin Nutr</addtitle><description>Background and Objectives: There is no evidence on antioxidant-rich diets in preventing hypertension in heat- exposed workers. We aimed to evaluate the effects of formula supplemented with vitamin C (Vit C) and hawthorn beverage on reducing blood pressure (BP) and oxidative stress levels in heat-exposed workers. Methods and Study Design: In the 40-day cluster-randomized controlled trial, four heat-exposed shift-teams were en- rolled and randomly assigned to the intervention and control groups. The intervention group was given one Vit C tablet (130 mg) and a 500 mL hawthorn beverage containing 278.7 mg flavonoids daily whereas the control group was given 500 mL of slightly salted water daily; both groups were provided education on a healthy diet. BP and creatinine-corrected urinary 8-isoprostane-prostaglandin F2alpha (8-iso-PGF2alpha/Cr) concentrations were assessed at baseline, Day 17 (only BP) and Day 41, respectively. Results: Compared with the control group, the systolic BP (SBP), diastolic BP (DBP), and log10-transformed 8-iso-PGF2alpha/Cr in the intervention group decreased by 7.41 mmHg, 7.93 mmHg and 0.232, respectively, from baseline to day 41 (all p<0.05). When comparing BP levels at baseline, DBP in the intervention group was reduced by 5.46 mmHg when compared to control (p<0.05) among participants with lower baseline BP; SBP and DBP experienced reductions of 9.74 and 9.22 mmHg among participants with higher baseline BP (both p<0.05). Conclusions: Supplementation of Vit C and flavonoids rich hawthorn beverage to heat-exposed workers prevented elevated BP caused by heat exposure which May be attributed to its oxidative stress inhibition effects.</description><subject>Adult</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - pharmacology</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Beverages</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Clinical trials</subject><subject>Crataegus - chemistry</subject><subject>Dietary Supplements</subject><subject>Evaluation</subject><subject>Female</subject><subject>Flavonoids</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Hypertension - prevention & control</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Oxidative Stress - drug effects</subject><subject>Vitamin C</subject><issn>0964-7058</issn><issn>1440-6047</issn><issn>1440-6047</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Ustu1DAUjRCIDoVfAC_LIoPfidkgNCoFqYJNWVs3iTPjwYmD7UwLP8Lv4nRKASGxsnXvOec-zi2KFwSvJWHsFUz7dlxTTDmhmrEz_nKNMRYPihXhHJcS8-phscJK8rLCoj4pnsS4zwjGsXhcnDBFsWISr4of531v2oR8jw42wWBHtEEwdmgH12nnw4gaczABtgb1PgyzA-RzzHnfoSmYGOdgbvH-xnaQ7MGgmJY4yko7A6k0N5OPpkPXPnwxIb5GgFo3x2RCGTLRD_Z7zrZ-TME7l78pWHBPi0c9uGie3b2nxed351eb9-Xlp4sPm7eXJbCapbLqFUhOFGGUko5j4DzPjKs8lBCc9gIUBckEZgIkbXhDBWFd00nBSUNaxU6LN0fdaW4G07UmtwFOT8EOEL5pD1b_nRntTm_9QRPCalUTnhXO7hSC_zqbmPRgY2ucg9H4OWqGlaoxyf1l6PM_i91X-WVHBlwcAWGwSbfLPtpk_Rj3kKImOFtNpLbjYkUGpOMB0Do7i7lUhBKJ66pSgt3v6xYIE_RJRwOh3f2m-7DVnbf_6l79T5cddcEGm6ze-zmM2SC93NpyavrjQsY1I5kr9aIg2E9qO9Ku</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Du, Wei</creator><creator>Zhang, Shuhan</creator><creator>Yang, Jiajia</creator><creator>Fan, Hongmin</creator><general>HEC Press</general><general>APJCN</general><scope>188</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241201</creationdate><title>Effect of vitamin C and hawthorn beverage formula on blood pressure and oxidative stress in heat-exposed workers: a cluster-randomized controlled trial</title><author>Du, Wei ; Zhang, Shuhan ; Yang, Jiajia ; Fan, Hongmin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a383t-7f9a641913221d40a4496407ffe5542f5a92a635035a62b4b2513dbd6541b1c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - pharmacology</topic><topic>Ascorbic Acid - administration & dosage</topic><topic>Ascorbic Acid - pharmacology</topic><topic>Beverages</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Clinical trials</topic><topic>Crataegus - chemistry</topic><topic>Dietary Supplements</topic><topic>Evaluation</topic><topic>Female</topic><topic>Flavonoids</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Hypertension - prevention & control</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Oxidative Stress - drug effects</topic><topic>Vitamin C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Wei</creatorcontrib><creatorcontrib>Zhang, Shuhan</creatorcontrib><creatorcontrib>Yang, Jiajia</creatorcontrib><creatorcontrib>Fan, Hongmin</creatorcontrib><collection>Airiti Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asia Pacific Journal of Clinical Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Wei</au><au>Zhang, Shuhan</au><au>Yang, Jiajia</au><au>Fan, Hongmin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vitamin C and hawthorn beverage formula on blood pressure and oxidative stress in heat-exposed workers: a cluster-randomized controlled trial</atitle><jtitle>Asia Pacific Journal of Clinical Nutrition</jtitle><addtitle>Asia Pac J Clin Nutr</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>33</volume><issue>4</issue><spage>503</spage><epage>514</epage><pages>503-514</pages><issn>0964-7058</issn><issn>1440-6047</issn><eissn>1440-6047</eissn><abstract>Background and Objectives: There is no evidence on antioxidant-rich diets in preventing hypertension in heat- exposed workers. We aimed to evaluate the effects of formula supplemented with vitamin C (Vit C) and hawthorn beverage on reducing blood pressure (BP) and oxidative stress levels in heat-exposed workers. Methods and Study Design: In the 40-day cluster-randomized controlled trial, four heat-exposed shift-teams were en- rolled and randomly assigned to the intervention and control groups. The intervention group was given one Vit C tablet (130 mg) and a 500 mL hawthorn beverage containing 278.7 mg flavonoids daily whereas the control group was given 500 mL of slightly salted water daily; both groups were provided education on a healthy diet. BP and creatinine-corrected urinary 8-isoprostane-prostaglandin F2alpha (8-iso-PGF2alpha/Cr) concentrations were assessed at baseline, Day 17 (only BP) and Day 41, respectively. Results: Compared with the control group, the systolic BP (SBP), diastolic BP (DBP), and log10-transformed 8-iso-PGF2alpha/Cr in the intervention group decreased by 7.41 mmHg, 7.93 mmHg and 0.232, respectively, from baseline to day 41 (all p<0.05). When comparing BP levels at baseline, DBP in the intervention group was reduced by 5.46 mmHg when compared to control (p<0.05) among participants with lower baseline BP; SBP and DBP experienced reductions of 9.74 and 9.22 mmHg among participants with higher baseline BP (both p<0.05). Conclusions: Supplementation of Vit C and flavonoids rich hawthorn beverage to heat-exposed workers prevented elevated BP caused by heat exposure which May be attributed to its oxidative stress inhibition effects.</abstract><cop>Clayton, Vic</cop><pub>HEC Press</pub><pmid>39209360</pmid><doi>10.6133/apjcn.202412_33(4).0005</doi><tpages>12</tpages></addata></record> |
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| subjects | Adult Antioxidants - administration & dosage Antioxidants - pharmacology Ascorbic Acid - administration & dosage Ascorbic Acid - pharmacology Beverages Blood pressure Blood Pressure - drug effects Clinical trials Crataegus - chemistry Dietary Supplements Evaluation Female Flavonoids Hot Temperature Humans Hypertension - prevention & control Male Middle Aged Original Oxidative Stress - drug effects Vitamin C |
| title | Effect of vitamin C and hawthorn beverage formula on blood pressure and oxidative stress in heat-exposed workers: a cluster-randomized controlled trial |
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