Artificial parasin I protein (API) supplementation improves growth performance and intestinal health in weaned piglets challenged with enterotoxigenic Escherichiacoli
Diarrheas are common risks faced by piglets during the weaning period. This study investigated the alleviating effects of artificial parasin I protein (API) on growth performance and intestinal health of weaned pigs upon enterotoxigenic Escherichia coli (ETEC) challenge. Sixty piglets were randomly...
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| Veröffentlicht in: | Animal Nutrition 2024-09, Vol.18, p.154-165 |
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| creator | Zou, Congzhi Zhao, Wanxin Yin, Shenggang Xiang, Xiaoyu Tang, Jiayong Jia, Gang Che, Lianqiang Liu, Guangmang Chen, Xiaoling Tian, Gang Cai, Jingyi Kang, Bo Zhao, Hua |
| description | Diarrheas are common risks faced by piglets during the weaning period. This study investigated the alleviating effects of artificial parasin I protein (API) on growth performance and intestinal health of weaned pigs upon enterotoxigenic Escherichia coli (ETEC) challenge. Sixty piglets were randomly divided into five groups and fed a basal diet (CON) or basal diet supplemented with API at 0, 750, and 1500 mg/kg or antibiotics for 5 weeks. On d 15 and 25, piglets were challenged with ETEC K88 except for the CON group. Before the ETEC challenge (d 1–14), dietary API supplementation improved growth performance, and 750 mg API increased (P |
| doi_str_mv | 10.1016/j.aninu.2024.04.015 |
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This study investigated the alleviating effects of artificial parasin I protein (API) on growth performance and intestinal health of weaned pigs upon enterotoxigenic Escherichia coli (ETEC) challenge. Sixty piglets were randomly divided into five groups and fed a basal diet (CON) or basal diet supplemented with API at 0, 750, and 1500 mg/kg or antibiotics for 5 weeks. On d 15 and 25, piglets were challenged with ETEC K88 except for the CON group. Before the ETEC challenge (d 1–14), dietary API supplementation improved growth performance, and 750 mg API increased (P < 0.05) the average daily gain (ADG), decreased (P < 0.05) feed to gain ratio (F/G) and diarrhea index of weaned piglets. ETEC challenge (during d 15–35) reduced growth performance and increased (P < 0.01) the F/G, diarrhea rate, and diarrhea index. This event was accompanied by the numerically increased malondialdehyde (MDA) levels in serum and ileum, the decreased (P < 0.05) zonula-occludens-1 (ZO-1) and interleukin-6 (IL-6) in the ileum, and the increased (P = 0.04) secretory immunoglobulin A (sIgA) protein in the ileum. Artificial parasin I protein supplementation alleviated the negative impact of ETEC. The 750 mg/kg API inclusion elevated (P < 0.05) ADG and decreased (P < 0.05) F/G. Two levels of API decreased (P < 0.01) the diarrhea rate and diarrhea index. Meanwhile, API inclusion decreased (P < 0.01) the crypt depth in the jejunum, elevated (P < 0.05) villus height in the duodenum and villus height to crypt depth ratio in the duodenum and ileum, up-regulated (P < 0.05) ZO-1 gene, and down-regulated (P < 0.05) mucin-2 gene in the jejunum, and 1500 mg/kg API decreased (P < 0.01) sIgA level and down-regulated (P < 0.05) IL-1β gene in the ileum. Furthermore, 750 mg/kg API elevated (P < 0.01) Bifidobacteria population and acetic acid concentrations in the cecal chyme. In conclusion, API supplementation alleviates the negative impact of ETEC on growth performance and intestinal health, thus can be applied as an antibiotic alternative in weaned piglets.]]></description><identifier>ISSN: 2405-6545</identifier><identifier>EISSN: 2405-6383</identifier><identifier>DOI: 10.1016/j.aninu.2024.04.015</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Artificial parasin I protein ; Diarrhea ; Growth performance ; Intestinal barrier ; Original ; Weaned piglet</subject><ispartof>Animal Nutrition, 2024-09, Vol.18, p.154-165</ispartof><rights>2024 The Authors</rights><rights>2024 The Authors 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-1681-0668</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11388718/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11388718/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Zou, Congzhi</creatorcontrib><creatorcontrib>Zhao, Wanxin</creatorcontrib><creatorcontrib>Yin, Shenggang</creatorcontrib><creatorcontrib>Xiang, Xiaoyu</creatorcontrib><creatorcontrib>Tang, Jiayong</creatorcontrib><creatorcontrib>Jia, Gang</creatorcontrib><creatorcontrib>Che, Lianqiang</creatorcontrib><creatorcontrib>Liu, Guangmang</creatorcontrib><creatorcontrib>Chen, Xiaoling</creatorcontrib><creatorcontrib>Tian, Gang</creatorcontrib><creatorcontrib>Cai, Jingyi</creatorcontrib><creatorcontrib>Kang, Bo</creatorcontrib><creatorcontrib>Zhao, Hua</creatorcontrib><title>Artificial parasin I protein (API) supplementation improves growth performance and intestinal health in weaned piglets challenged with enterotoxigenic Escherichiacoli</title><title>Animal Nutrition</title><description><![CDATA[Diarrheas are common risks faced by piglets during the weaning period. This study investigated the alleviating effects of artificial parasin I protein (API) on growth performance and intestinal health of weaned pigs upon enterotoxigenic Escherichia coli (ETEC) challenge. Sixty piglets were randomly divided into five groups and fed a basal diet (CON) or basal diet supplemented with API at 0, 750, and 1500 mg/kg or antibiotics for 5 weeks. On d 15 and 25, piglets were challenged with ETEC K88 except for the CON group. Before the ETEC challenge (d 1–14), dietary API supplementation improved growth performance, and 750 mg API increased (P < 0.05) the average daily gain (ADG), decreased (P < 0.05) feed to gain ratio (F/G) and diarrhea index of weaned piglets. ETEC challenge (during d 15–35) reduced growth performance and increased (P < 0.01) the F/G, diarrhea rate, and diarrhea index. This event was accompanied by the numerically increased malondialdehyde (MDA) levels in serum and ileum, the decreased (P < 0.05) zonula-occludens-1 (ZO-1) and interleukin-6 (IL-6) in the ileum, and the increased (P = 0.04) secretory immunoglobulin A (sIgA) protein in the ileum. Artificial parasin I protein supplementation alleviated the negative impact of ETEC. The 750 mg/kg API inclusion elevated (P < 0.05) ADG and decreased (P < 0.05) F/G. Two levels of API decreased (P < 0.01) the diarrhea rate and diarrhea index. Meanwhile, API inclusion decreased (P < 0.01) the crypt depth in the jejunum, elevated (P < 0.05) villus height in the duodenum and villus height to crypt depth ratio in the duodenum and ileum, up-regulated (P < 0.05) ZO-1 gene, and down-regulated (P < 0.05) mucin-2 gene in the jejunum, and 1500 mg/kg API decreased (P < 0.01) sIgA level and down-regulated (P < 0.05) IL-1β gene in the ileum. Furthermore, 750 mg/kg API elevated (P < 0.01) Bifidobacteria population and acetic acid concentrations in the cecal chyme. In conclusion, API supplementation alleviates the negative impact of ETEC on growth performance and intestinal health, thus can be applied as an antibiotic alternative in weaned piglets.]]></description><subject>Artificial parasin I protein</subject><subject>Diarrhea</subject><subject>Growth performance</subject><subject>Intestinal barrier</subject><subject>Original</subject><subject>Weaned piglet</subject><issn>2405-6545</issn><issn>2405-6383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpVkcFq3DAQhk1poCHNE-SiY3vYrWRZtvdQyhLSdiHQHpKzGEtje4IsGUm7275Qn7NK0x4KAzPMDN_8zF9VN4JvBRfth6ctePLHbc3rZstLCPWquqwbrjat7OXrf7Vq1JvqOiUaeN0pUUvRXFa_9jHTSIbAsRUiJPLswNYYMpbq3f774T1Lx3V1uKDPkCl4RkuZnzCxKYZzntmKcQxxAW-QgbeMfMaUyRfkjODKRkGdETxattLkMCdmZnAO_VRaZyobBY7laPhBE3oy7C6ZGSOZmcAER2-rixFcwuu_-ap6_Hz3cPt1c__ty-F2f79BIXi_aS32oxRiN1gAU8vaDrK1MCjb7nZ910gpTD-OcoRRCTnWqIzddRYaITvetFJeVZ9euOtxWNCaIiuC02ukBeJPHYD0_xNPs57CSQsh-74TfSF8fCFgkXkijDoZwvIaSxFN1jaQFlw_O6ef9B_n9LNzmpcQSv4GBZCVkw</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Zou, Congzhi</creator><creator>Zhao, Wanxin</creator><creator>Yin, Shenggang</creator><creator>Xiang, Xiaoyu</creator><creator>Tang, Jiayong</creator><creator>Jia, Gang</creator><creator>Che, Lianqiang</creator><creator>Liu, Guangmang</creator><creator>Chen, Xiaoling</creator><creator>Tian, Gang</creator><creator>Cai, Jingyi</creator><creator>Kang, Bo</creator><creator>Zhao, Hua</creator><general>Elsevier B.V</general><general>KeAi Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1681-0668</orcidid></search><sort><creationdate>202409</creationdate><title>Artificial parasin I protein (API) supplementation improves growth performance and intestinal health in weaned piglets challenged with enterotoxigenic Escherichiacoli</title><author>Zou, Congzhi ; Zhao, Wanxin ; Yin, Shenggang ; Xiang, Xiaoyu ; Tang, Jiayong ; Jia, Gang ; Che, Lianqiang ; Liu, Guangmang ; Chen, Xiaoling ; Tian, Gang ; Cai, Jingyi ; Kang, Bo ; Zhao, Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1108-6de8f3119bdaac232db36dab5d699874331c8ff3faf513f2e5cd97da413704633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Artificial parasin I protein</topic><topic>Diarrhea</topic><topic>Growth performance</topic><topic>Intestinal barrier</topic><topic>Original</topic><topic>Weaned piglet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zou, Congzhi</creatorcontrib><creatorcontrib>Zhao, Wanxin</creatorcontrib><creatorcontrib>Yin, Shenggang</creatorcontrib><creatorcontrib>Xiang, Xiaoyu</creatorcontrib><creatorcontrib>Tang, Jiayong</creatorcontrib><creatorcontrib>Jia, Gang</creatorcontrib><creatorcontrib>Che, Lianqiang</creatorcontrib><creatorcontrib>Liu, Guangmang</creatorcontrib><creatorcontrib>Chen, Xiaoling</creatorcontrib><creatorcontrib>Tian, Gang</creatorcontrib><creatorcontrib>Cai, Jingyi</creatorcontrib><creatorcontrib>Kang, Bo</creatorcontrib><creatorcontrib>Zhao, Hua</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Animal Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zou, Congzhi</au><au>Zhao, Wanxin</au><au>Yin, Shenggang</au><au>Xiang, Xiaoyu</au><au>Tang, Jiayong</au><au>Jia, Gang</au><au>Che, Lianqiang</au><au>Liu, Guangmang</au><au>Chen, Xiaoling</au><au>Tian, Gang</au><au>Cai, Jingyi</au><au>Kang, Bo</au><au>Zhao, Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Artificial parasin I protein (API) supplementation improves growth performance and intestinal health in weaned piglets challenged with enterotoxigenic Escherichiacoli</atitle><jtitle>Animal Nutrition</jtitle><date>2024-09</date><risdate>2024</risdate><volume>18</volume><spage>154</spage><epage>165</epage><pages>154-165</pages><issn>2405-6545</issn><eissn>2405-6383</eissn><abstract><![CDATA[Diarrheas are common risks faced by piglets during the weaning period. This study investigated the alleviating effects of artificial parasin I protein (API) on growth performance and intestinal health of weaned pigs upon enterotoxigenic Escherichia coli (ETEC) challenge. Sixty piglets were randomly divided into five groups and fed a basal diet (CON) or basal diet supplemented with API at 0, 750, and 1500 mg/kg or antibiotics for 5 weeks. On d 15 and 25, piglets were challenged with ETEC K88 except for the CON group. Before the ETEC challenge (d 1–14), dietary API supplementation improved growth performance, and 750 mg API increased (P < 0.05) the average daily gain (ADG), decreased (P < 0.05) feed to gain ratio (F/G) and diarrhea index of weaned piglets. ETEC challenge (during d 15–35) reduced growth performance and increased (P < 0.01) the F/G, diarrhea rate, and diarrhea index. This event was accompanied by the numerically increased malondialdehyde (MDA) levels in serum and ileum, the decreased (P < 0.05) zonula-occludens-1 (ZO-1) and interleukin-6 (IL-6) in the ileum, and the increased (P = 0.04) secretory immunoglobulin A (sIgA) protein in the ileum. Artificial parasin I protein supplementation alleviated the negative impact of ETEC. The 750 mg/kg API inclusion elevated (P < 0.05) ADG and decreased (P < 0.05) F/G. Two levels of API decreased (P < 0.01) the diarrhea rate and diarrhea index. Meanwhile, API inclusion decreased (P < 0.01) the crypt depth in the jejunum, elevated (P < 0.05) villus height in the duodenum and villus height to crypt depth ratio in the duodenum and ileum, up-regulated (P < 0.05) ZO-1 gene, and down-regulated (P < 0.05) mucin-2 gene in the jejunum, and 1500 mg/kg API decreased (P < 0.01) sIgA level and down-regulated (P < 0.05) IL-1β gene in the ileum. Furthermore, 750 mg/kg API elevated (P < 0.01) Bifidobacteria population and acetic acid concentrations in the cecal chyme. In conclusion, API supplementation alleviates the negative impact of ETEC on growth performance and intestinal health, thus can be applied as an antibiotic alternative in weaned piglets.]]></abstract><pub>Elsevier B.V</pub><doi>10.1016/j.aninu.2024.04.015</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-1681-0668</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Artificial parasin I protein Diarrhea Growth performance Intestinal barrier Original Weaned piglet |
| title | Artificial parasin I protein (API) supplementation improves growth performance and intestinal health in weaned piglets challenged with enterotoxigenic Escherichiacoli |
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