A structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8

Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that has a strong HLA association, where a number of self-epitopes have been implicated in disease pathogenesis. Human pancreatic islet-infiltrating CD4+ T cell clones not only respond to proinsulin C-peptide (PI40-54; GQVELGGGPGAGSLQ) bu...

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Veröffentlicht in:	The Journal of biological chemistry 2024-09, Vol.300 (9), p.107612, Article 107612
Hauptverfasser:	Tran, Mai T., Lim, Jia Jia, Loh, Tiing Jen, Mannering, Stuart I., Rossjohn, Jamie, Reid, Hugh H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen Presentation Autoantigens - chemistry Autoantigens - immunology autoimmunity CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cross Reactions Crystallography, X-Ray Diabetes Mellitus, Type 1 - immunology Epitopes, T-Lymphocyte - immunology HLA-DQ Antigens - chemistry HLA-DQ Antigens - genetics HLA-DQ Antigens - immunology Humans hybrid insulin peptide (HIP) Islet Amyloid Polypeptide - chemistry Islet Amyloid Polypeptide - genetics Islet Amyloid Polypeptide - immunology Islet Amyloid Polypeptide - metabolism major histocompatibility complex (MHC) Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism T cell receptor cross-reactivity TCR-pMHC complexes Type 1 diabetes
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