Brain organoids: A new tool for modelling of neurodevelopmental disorders
Neurodevelopmental disorders are mostly studied using mice as models. However, the mouse brain lacks similar cell types and structures as those of the human brain. In recent years, emergence of three‐dimensional brain organoids derived from human embryonic stem cells or induced pluripotent stem cell...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2024-09, Vol.28 (17), p.e18560-n/a |
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| description | Neurodevelopmental disorders are mostly studied using mice as models. However, the mouse brain lacks similar cell types and structures as those of the human brain. In recent years, emergence of three‐dimensional brain organoids derived from human embryonic stem cells or induced pluripotent stem cells allows for controlled monitoring and evaluation of early neurodevelopmental processes and has opened a window for studying various aspects of human brain development. However, such organoids lack original anatomical structure of the brain during maturation, and neurodevelopmental maturation processes that rely on unique cellular interactions and neural network connections are limited. Consequently, organoids are difficult to be used extensively and effectively while modelling later stages of human brain development and disease progression. To address this problem, several methods and technologies have emerged that aim to enhance the sophisticated regulation of brain organoids developmental processes through bioengineering approaches, which may alleviate some of the current limitations. This review discusses recent advances and application areas of human brain organoid culture methods, aiming to generalize optimization strategies for organoid systems, improve the ability to mimic human brain development, and enhance the application value of organoids. |
| doi_str_mv | 10.1111/jcmm.18560 |
| format | Article |
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However, the mouse brain lacks similar cell types and structures as those of the human brain. In recent years, emergence of three‐dimensional brain organoids derived from human embryonic stem cells or induced pluripotent stem cells allows for controlled monitoring and evaluation of early neurodevelopmental processes and has opened a window for studying various aspects of human brain development. However, such organoids lack original anatomical structure of the brain during maturation, and neurodevelopmental maturation processes that rely on unique cellular interactions and neural network connections are limited. Consequently, organoids are difficult to be used extensively and effectively while modelling later stages of human brain development and disease progression. To address this problem, several methods and technologies have emerged that aim to enhance the sophisticated regulation of brain organoids developmental processes through bioengineering approaches, which may alleviate some of the current limitations. This review discusses recent advances and application areas of human brain organoid culture methods, aiming to generalize optimization strategies for organoid systems, improve the ability to mimic human brain development, and enhance the application value of organoids.</description><identifier>ISSN: 1582-1838</identifier><identifier>ISSN: 1582-4934</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.18560</identifier><identifier>PMID: 39258535</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Animal models ; Animals ; Brain - cytology ; Brain - growth & development ; Brain - pathology ; brain organoids ; Brain research ; Cell culture ; Developmental stages ; Disease ; Embryo cells ; Embryogenesis ; Genes ; Humans ; Hypothalamus ; induced pluripotent stem cells ; Induced Pluripotent Stem Cells - cytology ; Induced Pluripotent Stem Cells - metabolism ; Maturation ; Models, Biological ; Nervous system ; Neural networks ; Neural stem cells ; Neurobiology ; neurodevelopmental diseases ; Neurodevelopmental disorders ; Neurodevelopmental Disorders - pathology ; Neurosciences ; Organoids ; Pathogenesis ; Pluripotency ; preclinical models ; Review ; Stem cells</subject><ispartof>Journal of cellular and molecular medicine, 2024-09, Vol.28 (17), p.e18560-n/a</ispartof><rights>2024 The Author(s). published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2024 The Author(s). Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3380-7ae2f133e307eb2379922be4621a7ab3a789af084f0a443dd75390e1de97c4a03</cites><orcidid>0000-0002-8411-5678</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11388061/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11388061/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39258535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aili, Yirizhati</creatorcontrib><creatorcontrib>Maimaitiming, Nuersimanguli</creatorcontrib><creatorcontrib>Wang, Zengliang</creatorcontrib><creatorcontrib>Wang, Yongxin</creatorcontrib><title>Brain organoids: A new tool for modelling of neurodevelopmental disorders</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>Neurodevelopmental disorders are mostly studied using mice as models. However, the mouse brain lacks similar cell types and structures as those of the human brain. In recent years, emergence of three‐dimensional brain organoids derived from human embryonic stem cells or induced pluripotent stem cells allows for controlled monitoring and evaluation of early neurodevelopmental processes and has opened a window for studying various aspects of human brain development. However, such organoids lack original anatomical structure of the brain during maturation, and neurodevelopmental maturation processes that rely on unique cellular interactions and neural network connections are limited. Consequently, organoids are difficult to be used extensively and effectively while modelling later stages of human brain development and disease progression. To address this problem, several methods and technologies have emerged that aim to enhance the sophisticated regulation of brain organoids developmental processes through bioengineering approaches, which may alleviate some of the current limitations. This review discusses recent advances and application areas of human brain organoid culture methods, aiming to generalize optimization strategies for organoid systems, improve the ability to mimic human brain development, and enhance the application value of organoids.</description><subject>Animal models</subject><subject>Animals</subject><subject>Brain - cytology</subject><subject>Brain - growth & development</subject><subject>Brain - pathology</subject><subject>brain organoids</subject><subject>Brain research</subject><subject>Cell culture</subject><subject>Developmental stages</subject><subject>Disease</subject><subject>Embryo cells</subject><subject>Embryogenesis</subject><subject>Genes</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>induced pluripotent stem cells</subject><subject>Induced Pluripotent Stem Cells - cytology</subject><subject>Induced Pluripotent Stem Cells - metabolism</subject><subject>Maturation</subject><subject>Models, Biological</subject><subject>Nervous system</subject><subject>Neural networks</subject><subject>Neural stem cells</subject><subject>Neurobiology</subject><subject>neurodevelopmental diseases</subject><subject>Neurodevelopmental disorders</subject><subject>Neurodevelopmental Disorders - pathology</subject><subject>Neurosciences</subject><subject>Organoids</subject><subject>Pathogenesis</subject><subject>Pluripotency</subject><subject>preclinical models</subject><subject>Review</subject><subject>Stem cells</subject><issn>1582-1838</issn><issn>1582-4934</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1PAjEQhhujEUQv_gCziRdjArad_eh6MUj8DMSLnpuyO4slu1tsWQj_3iJI1INz6UzmyZt3-hJyymiP-bqaZlXVYyKK6R5ps0jwbphCuL_tmQDRIkfOTSmFmEF6SFqQ8khEELXJ061Vug6Mnaja6NxdB_2gxmUwN6YMCmODyuRYlrqeBKbwm8b6eYGlmVVYz1UZ5NoZm6N1x-SgUKXDk-3bIW_3d6-Dx-7w5eFp0B92MwBBu4lCXjAABJrgmEOSppyPMYw5U4kag0pEqgoqwoKqMIQ8TyJIKbIc0yQLFYUOudnozppxhXnmbVhVypnVlbIraZSWvze1fpcTs5CMgRDU_0CHXGwVrPlo0M1lpV3mr1Q1msZJYJQLwWIKHj3_g05NY2t_35qCJGI84p663FCZNc5ZLHZuGJXriOQ6IvkVkYfPfvrfod-ZeIBtgKUucfWPlHwejEYb0U9km5vt</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Aili, Yirizhati</creator><creator>Maimaitiming, Nuersimanguli</creator><creator>Wang, Zengliang</creator><creator>Wang, Yongxin</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8411-5678</orcidid></search><sort><creationdate>202409</creationdate><title>Brain organoids: A new tool for modelling of neurodevelopmental disorders</title><author>Aili, Yirizhati ; Maimaitiming, Nuersimanguli ; Wang, Zengliang ; Wang, Yongxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3380-7ae2f133e307eb2379922be4621a7ab3a789af084f0a443dd75390e1de97c4a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Brain - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aili, Yirizhati</au><au>Maimaitiming, Nuersimanguli</au><au>Wang, Zengliang</au><au>Wang, Yongxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain organoids: A new tool for modelling of neurodevelopmental disorders</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2024-09</date><risdate>2024</risdate><volume>28</volume><issue>17</issue><spage>e18560</spage><epage>n/a</epage><pages>e18560-n/a</pages><issn>1582-1838</issn><issn>1582-4934</issn><eissn>1582-4934</eissn><abstract>Neurodevelopmental disorders are mostly studied using mice as models. However, the mouse brain lacks similar cell types and structures as those of the human brain. In recent years, emergence of three‐dimensional brain organoids derived from human embryonic stem cells or induced pluripotent stem cells allows for controlled monitoring and evaluation of early neurodevelopmental processes and has opened a window for studying various aspects of human brain development. However, such organoids lack original anatomical structure of the brain during maturation, and neurodevelopmental maturation processes that rely on unique cellular interactions and neural network connections are limited. Consequently, organoids are difficult to be used extensively and effectively while modelling later stages of human brain development and disease progression. To address this problem, several methods and technologies have emerged that aim to enhance the sophisticated regulation of brain organoids developmental processes through bioengineering approaches, which may alleviate some of the current limitations. This review discusses recent advances and application areas of human brain organoid culture methods, aiming to generalize optimization strategies for organoid systems, improve the ability to mimic human brain development, and enhance the application value of organoids.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>39258535</pmid><doi>10.1111/jcmm.18560</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-8411-5678</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animal models Animals Brain - cytology Brain - growth & development Brain - pathology brain organoids Brain research Cell culture Developmental stages Disease Embryo cells Embryogenesis Genes Humans Hypothalamus induced pluripotent stem cells Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Maturation Models, Biological Nervous system Neural networks Neural stem cells Neurobiology neurodevelopmental diseases Neurodevelopmental disorders Neurodevelopmental Disorders - pathology Neurosciences Organoids Pathogenesis Pluripotency preclinical models Review Stem cells |
| title | Brain organoids: A new tool for modelling of neurodevelopmental disorders |
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