Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling

The DNA damage response (DDR) and the blood-tumor barrier (BTB) restrict chemotherapeutic success for primary brain tumors like glioblastomas (GBMs). Coherently, GBMs almost invariably relapse with fatal outcomes. Here, we show that the interaction of GBM and myeloid cells simultaneously induces che...

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Veröffentlicht in:	Cell reports. Medicine 2024-08, Vol.5 (8), p.101658, Article 101658
Hauptverfasser:	Cheng, Jiying, Li, Min, Motta, Edyta, Barci, Deivi, Song, Wangyang, Zhou, Ding, Li, Gen, Zhu, Sihan, Yang, Anru, Vaillant, Brian D., Imhof, Axel, Forné, Ignasi, Spiegl-Kreinecker, Sabine, Zhang, Nu, Katayama, Hiroshi, Bhat, Krishna P.L., Flüh, Charlotte, Kälin, Roland E., Glass, Rainer
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood-tumor barrier Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Line, Tumor chemotherapy Cytokine Receptor gp130 - genetics Cytokine Receptor gp130 - metabolism DDR DNA Damage - drug effects DNA damage response Drug Resistance, Neoplasm - drug effects glioblastoma Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioma - drug therapy Glioma - genetics Glioma - metabolism Glioma - pathology GP130 humanin Humans IL6ST Mice Myeloid Cells - drug effects Myeloid Cells - metabolism Signal Transduction - drug effects TAM temozolomide Temozolomide - pharmacology tumor-associated myeloid cells
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