Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells
Antizyme, a spermidine-induced protein that binds and stimulates ornithine decarboxylase degradation, is now shown also to mediate the rapid feedback inhibition of polyamine uptake into mammalian cells. Using a cell line (HZ7) transfected with truncated antizyme cDNA, and mutant ornithine decarboxyl...
Gespeichert in:
| Veröffentlicht in: | Biochemical journal 1994-04, Vol.299 (1), p.19-22 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 22 |
|---|---|
| container_issue | 1 |
| container_start_page | 19 |
| container_title | Biochemical journal |
| container_volume | 299 |
| creator | MITCHELL, J. L. A JUDD, G. G BAREYAL-LEYSER, A LING, S. Y |
| description | Antizyme, a spermidine-induced protein that binds and stimulates ornithine decarboxylase degradation, is now shown also to mediate the rapid feedback inhibition of polyamine uptake into mammalian cells. Using a cell line (HZ7) transfected with truncated antizyme cDNA, and mutant ornithine decarboxylase cell lines, we demonstrate that this newly discovered action of antizyme is distinct from its role in modulating polyamine biosynthesis. |
| doi_str_mv | 10.1042/bj2990019 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1138014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76450433</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3809-f64b4ee749c93330f4dc38bd07e85f81739bc1d99807c2b514f6ec156604024c3</originalsourceid><addsrcrecordid>eNpVkU9LJDEQxYOs6Dh68AMs5LAIHlqTTibduSyI-A8EL3oO6XS1xu1O2lS3MH56Iw7DeqrDe7z6VT1Cjjk740yW581rqTVjXO-QBZcVK-qqrH-RBSuVLBQr-T45QHzNDskk2yN7NVdKCb0g7TVA21j3jyYYEyD6GGjs6Bj7tR18ADolG3CMaaIe6QCttxO0tFlTGyb_sR6A-kAHOwy29zbQySPOULi5n-YE1EHf4yHZ7WyPcLSZS_J0ffV4eVvcP9zcXV7cF07UTBedko0EqKR2WgjBOtlmoWlZBfWqq3kldON4q3XNKlc2Ky47BY6vlMpHldKJJfn7nTvOTSZ1EDJ8b8bkB5vWJlpvfirBv5jn-G44zwBc5oCTTUCKbzPgZAaPXyfYAHFGUym5YjKzLcnpt9GliJig2y7hzHxVYraVZO_v_6m2zk0HWf-z0S0623f5387j1iZ0pZVk4hPArJVU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76450433</pqid></control><display><type>article</type><title>Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>MITCHELL, J. L. A ; JUDD, G. G ; BAREYAL-LEYSER, A ; LING, S. Y</creator><creatorcontrib>MITCHELL, J. L. A ; JUDD, G. G ; BAREYAL-LEYSER, A ; LING, S. Y</creatorcontrib><description>Antizyme, a spermidine-induced protein that binds and stimulates ornithine decarboxylase degradation, is now shown also to mediate the rapid feedback inhibition of polyamine uptake into mammalian cells. Using a cell line (HZ7) transfected with truncated antizyme cDNA, and mutant ornithine decarboxylase cell lines, we demonstrate that this newly discovered action of antizyme is distinct from its role in modulating polyamine biosynthesis.</description><identifier>ISSN: 0264-6021</identifier><identifier>EISSN: 1470-8728</identifier><identifier>DOI: 10.1042/bj2990019</identifier><identifier>PMID: 8166639</identifier><language>eng</language><publisher>Colchester: Portland Press</publisher><subject>Animals ; Base Sequence ; Biological and medical sciences ; Biological Transport ; Cell physiology ; Fundamental and applied biological sciences. Psychology ; Membrane and intracellular transports ; Molecular and cellular biology ; Molecular Sequence Data ; Oligodeoxyribonucleotides ; Ornithine Decarboxylase Inhibitors ; Polyamines - metabolism ; Proteins - metabolism ; Rats ; Tumor Cells, Cultured</subject><ispartof>Biochemical journal, 1994-04, Vol.299 (1), p.19-22</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3809-f64b4ee749c93330f4dc38bd07e85f81739bc1d99807c2b514f6ec156604024c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1138014/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1138014/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3979640$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8166639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MITCHELL, J. L. A</creatorcontrib><creatorcontrib>JUDD, G. G</creatorcontrib><creatorcontrib>BAREYAL-LEYSER, A</creatorcontrib><creatorcontrib>LING, S. Y</creatorcontrib><title>Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells</title><title>Biochemical journal</title><addtitle>Biochem J</addtitle><description>Antizyme, a spermidine-induced protein that binds and stimulates ornithine decarboxylase degradation, is now shown also to mediate the rapid feedback inhibition of polyamine uptake into mammalian cells. Using a cell line (HZ7) transfected with truncated antizyme cDNA, and mutant ornithine decarboxylase cell lines, we demonstrate that this newly discovered action of antizyme is distinct from its role in modulating polyamine biosynthesis.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biological Transport</subject><subject>Cell physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Membrane and intracellular transports</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Oligodeoxyribonucleotides</subject><subject>Ornithine Decarboxylase Inhibitors</subject><subject>Polyamines - metabolism</subject><subject>Proteins - metabolism</subject><subject>Rats</subject><subject>Tumor Cells, Cultured</subject><issn>0264-6021</issn><issn>1470-8728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU9LJDEQxYOs6Dh68AMs5LAIHlqTTibduSyI-A8EL3oO6XS1xu1O2lS3MH56Iw7DeqrDe7z6VT1Cjjk740yW581rqTVjXO-QBZcVK-qqrH-RBSuVLBQr-T45QHzNDskk2yN7NVdKCb0g7TVA21j3jyYYEyD6GGjs6Bj7tR18ADolG3CMaaIe6QCttxO0tFlTGyb_sR6A-kAHOwy29zbQySPOULi5n-YE1EHf4yHZ7WyPcLSZS_J0ffV4eVvcP9zcXV7cF07UTBedko0EqKR2WgjBOtlmoWlZBfWqq3kldON4q3XNKlc2Ky47BY6vlMpHldKJJfn7nTvOTSZ1EDJ8b8bkB5vWJlpvfirBv5jn-G44zwBc5oCTTUCKbzPgZAaPXyfYAHFGUym5YjKzLcnpt9GliJig2y7hzHxVYraVZO_v_6m2zk0HWf-z0S0623f5387j1iZ0pZVk4hPArJVU</recordid><startdate>19940401</startdate><enddate>19940401</enddate><creator>MITCHELL, J. L. A</creator><creator>JUDD, G. G</creator><creator>BAREYAL-LEYSER, A</creator><creator>LING, S. Y</creator><general>Portland Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19940401</creationdate><title>Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells</title><author>MITCHELL, J. L. A ; JUDD, G. G ; BAREYAL-LEYSER, A ; LING, S. Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3809-f64b4ee749c93330f4dc38bd07e85f81739bc1d99807c2b514f6ec156604024c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biological Transport</topic><topic>Cell physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Membrane and intracellular transports</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Oligodeoxyribonucleotides</topic><topic>Ornithine Decarboxylase Inhibitors</topic><topic>Polyamines - metabolism</topic><topic>Proteins - metabolism</topic><topic>Rats</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MITCHELL, J. L. A</creatorcontrib><creatorcontrib>JUDD, G. G</creatorcontrib><creatorcontrib>BAREYAL-LEYSER, A</creatorcontrib><creatorcontrib>LING, S. Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MITCHELL, J. L. A</au><au>JUDD, G. G</au><au>BAREYAL-LEYSER, A</au><au>LING, S. Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells</atitle><jtitle>Biochemical journal</jtitle><addtitle>Biochem J</addtitle><date>1994-04-01</date><risdate>1994</risdate><volume>299</volume><issue>1</issue><spage>19</spage><epage>22</epage><pages>19-22</pages><issn>0264-6021</issn><eissn>1470-8728</eissn><abstract>Antizyme, a spermidine-induced protein that binds and stimulates ornithine decarboxylase degradation, is now shown also to mediate the rapid feedback inhibition of polyamine uptake into mammalian cells. Using a cell line (HZ7) transfected with truncated antizyme cDNA, and mutant ornithine decarboxylase cell lines, we demonstrate that this newly discovered action of antizyme is distinct from its role in modulating polyamine biosynthesis.</abstract><cop>Colchester</cop><pub>Portland Press</pub><pmid>8166639</pmid><doi>10.1042/bj2990019</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-6021 |
| ispartof | Biochemical journal, 1994-04, Vol.299 (1), p.19-22 |
| issn | 0264-6021 1470-8728 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1138014 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Base Sequence Biological and medical sciences Biological Transport Cell physiology Fundamental and applied biological sciences. Psychology Membrane and intracellular transports Molecular and cellular biology Molecular Sequence Data Oligodeoxyribonucleotides Ornithine Decarboxylase Inhibitors Polyamines - metabolism Proteins - metabolism Rats Tumor Cells, Cultured |
| title | Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T01%3A29%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Feedback%20repression%20of%20polyamine%20transport%20is%20mediated%20by%20antizyme%20in%20mammalian%20tissue-culture%20cells&rft.jtitle=Biochemical%20journal&rft.au=MITCHELL,%20J.%20L.%20A&rft.date=1994-04-01&rft.volume=299&rft.issue=1&rft.spage=19&rft.epage=22&rft.pages=19-22&rft.issn=0264-6021&rft.eissn=1470-8728&rft_id=info:doi/10.1042/bj2990019&rft_dat=%3Cproquest_pubme%3E76450433%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76450433&rft_id=info:pmid/8166639&rfr_iscdi=true |