Emerging trends and research hotspots in the relationship between mast cells and atopic dermatitis based on the literature from 2001 to 2024: A bibliometric and visualized analysis
Background Atopic dermatitis (AD) is a prevalent chronic inflammatory and highly pruritic skin condition characterized by the infiltration of immune cells, notably eosinophils and mast cells. Mast cells (MCs) critically participate in the complex pathogenesis of AD through multiple pathways and have...
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| description | Background
Atopic dermatitis (AD) is a prevalent chronic inflammatory and highly pruritic skin condition characterized by the infiltration of immune cells, notably eosinophils and mast cells. Mast cells (MCs) critically participate in the complex pathogenesis of AD through multiple pathways and have recently garnered growing attention in research. Despite the abundance of related studies published over the years, a comprehensive bibliometric analysis on this topic remains lacking.
Objective
Our objective was to perform an up‐to‐date bibliometric analysis of the literature focusing on the relationship between MCs and AD. This analysis would provide valuable insights through a thorough bibliometric review, enabling a clearer understanding of the current research landscape, pinpointing key studies, and detecting emerging trends within this field.
Methods
We searched the Web of Science Core Collection (WoSCC) database on 15 July 2024. The data retrieval strategy was structured as follows: #1: TS = (“mast cells”) OR TS = (“mast cell”) OR TS = (“mastocyte”); #2: TS = (“atopic dermatitis”) OR TS = (“atopic eczema”) Final data: (#1 AND #2). A total of 2272 items published between 2001 and 2024 were included. Several scientometric visualization tools, including VOSviewer, R‐bibliometrix, CiteSpace and an online analytical platform, were utilized to conduct text mining and to visualize the bibliometric data, facilitating a comprehensive analysis of research trends and patterns.
Results
Out of the initial 2272 articles retrieved, 2168 were selected for analysis after applying inclusion and exclusion criteria based on publication type. The findings indicate a steady and substantial exponential growth in the annual number of publications focused on the relationship between over the years. The South Korea (547/2168), USA (465/2168) and Japan (436/2168) were the major contributors within this field, collectively constituting more than half of the total publications. To clarify the underlying mechanisms and role of MCs in the pathogenesis of AD and to make MCs prime targets for therapeutic intervention have garnered the most attention in this field. According to references analysis, the research emphasis has shifted to developing MC‐related therapeutics and intervention and regulating the immune system of AD patients through modulating the activity of various immune cells. On the basis of keywords analysis, we outlined the following research frontiers and hotpots in the f |
| doi_str_mv | 10.1111/srt.70053 |
| format | Article |
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Atopic dermatitis (AD) is a prevalent chronic inflammatory and highly pruritic skin condition characterized by the infiltration of immune cells, notably eosinophils and mast cells. Mast cells (MCs) critically participate in the complex pathogenesis of AD through multiple pathways and have recently garnered growing attention in research. Despite the abundance of related studies published over the years, a comprehensive bibliometric analysis on this topic remains lacking.
Objective
Our objective was to perform an up‐to‐date bibliometric analysis of the literature focusing on the relationship between MCs and AD. This analysis would provide valuable insights through a thorough bibliometric review, enabling a clearer understanding of the current research landscape, pinpointing key studies, and detecting emerging trends within this field.
Methods
We searched the Web of Science Core Collection (WoSCC) database on 15 July 2024. The data retrieval strategy was structured as follows: #1: TS = (“mast cells”) OR TS = (“mast cell”) OR TS = (“mastocyte”); #2: TS = (“atopic dermatitis”) OR TS = (“atopic eczema”) Final data: (#1 AND #2). A total of 2272 items published between 2001 and 2024 were included. Several scientometric visualization tools, including VOSviewer, R‐bibliometrix, CiteSpace and an online analytical platform, were utilized to conduct text mining and to visualize the bibliometric data, facilitating a comprehensive analysis of research trends and patterns.
Results
Out of the initial 2272 articles retrieved, 2168 were selected for analysis after applying inclusion and exclusion criteria based on publication type. The findings indicate a steady and substantial exponential growth in the annual number of publications focused on the relationship between over the years. The South Korea (547/2168), USA (465/2168) and Japan (436/2168) were the major contributors within this field, collectively constituting more than half of the total publications. To clarify the underlying mechanisms and role of MCs in the pathogenesis of AD and to make MCs prime targets for therapeutic intervention have garnered the most attention in this field. According to references analysis, the research emphasis has shifted to developing MC‐related therapeutics and intervention and regulating the immune system of AD patients through modulating the activity of various immune cells. On the basis of keywords analysis, we outlined the following research frontiers and hotpots in the future: the role of oxidative stress in the pathogenesis; imbalance in the different types of T helper (Th) cells during immune response; skin barrier and barrier dysfunction; improving quality of life; sensory neurons; biological agents and small‐molecule drugs. Furthermore, IL‐13, IL‐4, NFKB1, BCGF‐1 and CD4 ranked as the top five genes that have received the most investigative attention in the intersection of MCs and AD.
Conclusion
In a word, this analysis would greatly benefit from a thorough bibliometric review to gain a deeper understanding of the current research landscape, identify pivotal studies and pinpoint emerging trends in the field of MCs and AD. Meanwhile, our findings offered researchers a holistic perspective of ongoing developments, serving as a valuable resource for guiding future research and informing decision‐making for both researchers and policymakers in this area.</description><identifier>ISSN: 0909-752X</identifier><identifier>ISSN: 1600-0846</identifier><identifier>EISSN: 1600-0846</identifier><identifier>DOI: 10.1111/srt.70053</identifier><identifier>PMID: 39234634</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Animals ; Atopic dermatitis ; Bibliometrics ; CD4 antigen ; CiteSpace ; Data mining ; Data retrieval ; Decision making ; Dermatitis ; Dermatitis, Atopic - immunology ; Eczema ; Eosinophils ; Helper cells ; Humans ; Immune response ; Immune system ; Immunosuppressive agents ; Leukocytes (eosinophilic) ; Lymphocytes T ; Mast cells ; Mast Cells - immunology ; Original ; Oxidative stress ; Pathogenesis ; Quality of life ; Scientometrics ; Sensory neurons ; Sensory properties ; Skin diseases ; Trends ; VOSviewer</subject><ispartof>Skin research and technology, 2024-09, Vol.30 (9), p.e70053-n/a</ispartof><rights>2024 The Author(s). published by John Wiley & Sons Ltd.</rights><rights>2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3343-817a40ea7a4e752a3c2902f25568d33f25980bdf5907b21a56304ba805a211b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375331/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375331/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,1418,11567,27929,27930,45579,45580,46057,46481,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39234634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zuo, Wen</creatorcontrib><creatorcontrib>Yue, Zhang</creatorcontrib><creatorcontrib>Xu, Shuang</creatorcontrib><creatorcontrib>Sun, Cai‐Hong</creatorcontrib><creatorcontrib>Zou, Xiong‐Fei</creatorcontrib><creatorcontrib>Ma, Jie</creatorcontrib><creatorcontrib>Yan, Han</creatorcontrib><creatorcontrib>Gu, Xiao‐Wen</creatorcontrib><creatorcontrib>Wang, Ming‐Yan</creatorcontrib><title>Emerging trends and research hotspots in the relationship between mast cells and atopic dermatitis based on the literature from 2001 to 2024: A bibliometric and visualized analysis</title><title>Skin research and technology</title><addtitle>Skin Res Technol</addtitle><description>Background
Atopic dermatitis (AD) is a prevalent chronic inflammatory and highly pruritic skin condition characterized by the infiltration of immune cells, notably eosinophils and mast cells. Mast cells (MCs) critically participate in the complex pathogenesis of AD through multiple pathways and have recently garnered growing attention in research. Despite the abundance of related studies published over the years, a comprehensive bibliometric analysis on this topic remains lacking.
Objective
Our objective was to perform an up‐to‐date bibliometric analysis of the literature focusing on the relationship between MCs and AD. This analysis would provide valuable insights through a thorough bibliometric review, enabling a clearer understanding of the current research landscape, pinpointing key studies, and detecting emerging trends within this field.
Methods
We searched the Web of Science Core Collection (WoSCC) database on 15 July 2024. The data retrieval strategy was structured as follows: #1: TS = (“mast cells”) OR TS = (“mast cell”) OR TS = (“mastocyte”); #2: TS = (“atopic dermatitis”) OR TS = (“atopic eczema”) Final data: (#1 AND #2). A total of 2272 items published between 2001 and 2024 were included. Several scientometric visualization tools, including VOSviewer, R‐bibliometrix, CiteSpace and an online analytical platform, were utilized to conduct text mining and to visualize the bibliometric data, facilitating a comprehensive analysis of research trends and patterns.
Results
Out of the initial 2272 articles retrieved, 2168 were selected for analysis after applying inclusion and exclusion criteria based on publication type. The findings indicate a steady and substantial exponential growth in the annual number of publications focused on the relationship between over the years. The South Korea (547/2168), USA (465/2168) and Japan (436/2168) were the major contributors within this field, collectively constituting more than half of the total publications. To clarify the underlying mechanisms and role of MCs in the pathogenesis of AD and to make MCs prime targets for therapeutic intervention have garnered the most attention in this field. According to references analysis, the research emphasis has shifted to developing MC‐related therapeutics and intervention and regulating the immune system of AD patients through modulating the activity of various immune cells. On the basis of keywords analysis, we outlined the following research frontiers and hotpots in the future: the role of oxidative stress in the pathogenesis; imbalance in the different types of T helper (Th) cells during immune response; skin barrier and barrier dysfunction; improving quality of life; sensory neurons; biological agents and small‐molecule drugs. Furthermore, IL‐13, IL‐4, NFKB1, BCGF‐1 and CD4 ranked as the top five genes that have received the most investigative attention in the intersection of MCs and AD.
Conclusion
In a word, this analysis would greatly benefit from a thorough bibliometric review to gain a deeper understanding of the current research landscape, identify pivotal studies and pinpoint emerging trends in the field of MCs and AD. Meanwhile, our findings offered researchers a holistic perspective of ongoing developments, serving as a valuable resource for guiding future research and informing decision‐making for both researchers and policymakers in this area.</description><subject>Animals</subject><subject>Atopic dermatitis</subject><subject>Bibliometrics</subject><subject>CD4 antigen</subject><subject>CiteSpace</subject><subject>Data mining</subject><subject>Data retrieval</subject><subject>Decision making</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Eczema</subject><subject>Eosinophils</subject><subject>Helper cells</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunosuppressive agents</subject><subject>Leukocytes (eosinophilic)</subject><subject>Lymphocytes T</subject><subject>Mast cells</subject><subject>Mast Cells - immunology</subject><subject>Original</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Quality of life</subject><subject>Scientometrics</subject><subject>Sensory neurons</subject><subject>Sensory properties</subject><subject>Skin diseases</subject><subject>Trends</subject><subject>VOSviewer</subject><issn>0909-752X</issn><issn>1600-0846</issn><issn>1600-0846</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kt1qFTEQgIMo9rR64QtIwBu92Hay2V9vpJT6AwVBK3gXZndnz6bsJmuSbTk-Vx_QnG4tKhhIJpAvH5PJMPZCwLGI48S7cFwC5PIR24gCIIEqKx6zDdRQJ2Wefj9gh95fQURqIZ-yA1mnMitktmG35xO5rTZbHhyZznM0HXfkCV078MEGP8fJteFhoHgwYtDW-EHPvKFwQ2T4hD7wlsZxvYzBzrrlHbkpskF73qCnjttVMepADsPiiPfOTjwFEDzYGNPsLT_ljW5GbScKLkr2vmvtFxz1z6hAg-POa_-MPelx9PT8Ph6xb-_PL88-JhefP3w6O71IWikzmVSixAwI40qxCijbtIa0T_O8qDop46auoOn6vIaySQXmhYSswQpyTIVocnnE3q3eeWkm6loyweGoZqcndDtlUau_T4we1NZeKyFkmUspouH1vcHZHwv5oCbt97VCQ3bxSgqAWlQAZURf_YNe2cXFF99RdVEUQqaRerNSrbPeO-ofshGg9s2gYjOou2aI7Ms_038gf_9-BE5W4EaPtPu_SX39crkqfwEAL8Bb</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Zuo, Wen</creator><creator>Yue, Zhang</creator><creator>Xu, Shuang</creator><creator>Sun, Cai‐Hong</creator><creator>Zou, Xiong‐Fei</creator><creator>Ma, Jie</creator><creator>Yan, Han</creator><creator>Gu, Xiao‐Wen</creator><creator>Wang, Ming‐Yan</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202409</creationdate><title>Emerging trends and research hotspots in the relationship between mast cells and atopic dermatitis based on the literature from 2001 to 2024: A bibliometric and visualized analysis</title><author>Zuo, Wen ; Yue, Zhang ; Xu, Shuang ; Sun, Cai‐Hong ; Zou, Xiong‐Fei ; Ma, Jie ; Yan, Han ; Gu, Xiao‐Wen ; Wang, Ming‐Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3343-817a40ea7a4e752a3c2902f25568d33f25980bdf5907b21a56304ba805a211b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Atopic dermatitis</topic><topic>Bibliometrics</topic><topic>CD4 antigen</topic><topic>CiteSpace</topic><topic>Data mining</topic><topic>Data retrieval</topic><topic>Decision making</topic><topic>Dermatitis</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Eczema</topic><topic>Eosinophils</topic><topic>Helper cells</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunosuppressive agents</topic><topic>Leukocytes (eosinophilic)</topic><topic>Lymphocytes T</topic><topic>Mast cells</topic><topic>Mast Cells - immunology</topic><topic>Original</topic><topic>Oxidative stress</topic><topic>Pathogenesis</topic><topic>Quality of life</topic><topic>Scientometrics</topic><topic>Sensory neurons</topic><topic>Sensory properties</topic><topic>Skin diseases</topic><topic>Trends</topic><topic>VOSviewer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zuo, Wen</creatorcontrib><creatorcontrib>Yue, Zhang</creatorcontrib><creatorcontrib>Xu, Shuang</creatorcontrib><creatorcontrib>Sun, Cai‐Hong</creatorcontrib><creatorcontrib>Zou, Xiong‐Fei</creatorcontrib><creatorcontrib>Ma, Jie</creatorcontrib><creatorcontrib>Yan, Han</creatorcontrib><creatorcontrib>Gu, Xiao‐Wen</creatorcontrib><creatorcontrib>Wang, Ming‐Yan</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Skin research and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zuo, Wen</au><au>Yue, Zhang</au><au>Xu, Shuang</au><au>Sun, Cai‐Hong</au><au>Zou, Xiong‐Fei</au><au>Ma, Jie</au><au>Yan, Han</au><au>Gu, Xiao‐Wen</au><au>Wang, Ming‐Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging trends and research hotspots in the relationship between mast cells and atopic dermatitis based on the literature from 2001 to 2024: A bibliometric and visualized analysis</atitle><jtitle>Skin research and technology</jtitle><addtitle>Skin Res Technol</addtitle><date>2024-09</date><risdate>2024</risdate><volume>30</volume><issue>9</issue><spage>e70053</spage><epage>n/a</epage><pages>e70053-n/a</pages><issn>0909-752X</issn><issn>1600-0846</issn><eissn>1600-0846</eissn><abstract>Background
Atopic dermatitis (AD) is a prevalent chronic inflammatory and highly pruritic skin condition characterized by the infiltration of immune cells, notably eosinophils and mast cells. Mast cells (MCs) critically participate in the complex pathogenesis of AD through multiple pathways and have recently garnered growing attention in research. Despite the abundance of related studies published over the years, a comprehensive bibliometric analysis on this topic remains lacking.
Objective
Our objective was to perform an up‐to‐date bibliometric analysis of the literature focusing on the relationship between MCs and AD. This analysis would provide valuable insights through a thorough bibliometric review, enabling a clearer understanding of the current research landscape, pinpointing key studies, and detecting emerging trends within this field.
Methods
We searched the Web of Science Core Collection (WoSCC) database on 15 July 2024. The data retrieval strategy was structured as follows: #1: TS = (“mast cells”) OR TS = (“mast cell”) OR TS = (“mastocyte”); #2: TS = (“atopic dermatitis”) OR TS = (“atopic eczema”) Final data: (#1 AND #2). A total of 2272 items published between 2001 and 2024 were included. Several scientometric visualization tools, including VOSviewer, R‐bibliometrix, CiteSpace and an online analytical platform, were utilized to conduct text mining and to visualize the bibliometric data, facilitating a comprehensive analysis of research trends and patterns.
Results
Out of the initial 2272 articles retrieved, 2168 were selected for analysis after applying inclusion and exclusion criteria based on publication type. The findings indicate a steady and substantial exponential growth in the annual number of publications focused on the relationship between over the years. The South Korea (547/2168), USA (465/2168) and Japan (436/2168) were the major contributors within this field, collectively constituting more than half of the total publications. To clarify the underlying mechanisms and role of MCs in the pathogenesis of AD and to make MCs prime targets for therapeutic intervention have garnered the most attention in this field. According to references analysis, the research emphasis has shifted to developing MC‐related therapeutics and intervention and regulating the immune system of AD patients through modulating the activity of various immune cells. On the basis of keywords analysis, we outlined the following research frontiers and hotpots in the future: the role of oxidative stress in the pathogenesis; imbalance in the different types of T helper (Th) cells during immune response; skin barrier and barrier dysfunction; improving quality of life; sensory neurons; biological agents and small‐molecule drugs. Furthermore, IL‐13, IL‐4, NFKB1, BCGF‐1 and CD4 ranked as the top five genes that have received the most investigative attention in the intersection of MCs and AD.
Conclusion
In a word, this analysis would greatly benefit from a thorough bibliometric review to gain a deeper understanding of the current research landscape, identify pivotal studies and pinpoint emerging trends in the field of MCs and AD. Meanwhile, our findings offered researchers a holistic perspective of ongoing developments, serving as a valuable resource for guiding future research and informing decision‐making for both researchers and policymakers in this area.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>39234634</pmid><doi>10.1111/srt.70053</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0909-752X |
| ispartof | Skin research and technology, 2024-09, Vol.30 (9), p.e70053-n/a |
| issn | 0909-752X 1600-0846 1600-0846 |
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| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11375331 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley-Blackwell Open Access Titles; Wiley Online Library All Journals; PubMed Central |
| subjects | Animals Atopic dermatitis Bibliometrics CD4 antigen CiteSpace Data mining Data retrieval Decision making Dermatitis Dermatitis, Atopic - immunology Eczema Eosinophils Helper cells Humans Immune response Immune system Immunosuppressive agents Leukocytes (eosinophilic) Lymphocytes T Mast cells Mast Cells - immunology Original Oxidative stress Pathogenesis Quality of life Scientometrics Sensory neurons Sensory properties Skin diseases Trends VOSviewer |
| title | Emerging trends and research hotspots in the relationship between mast cells and atopic dermatitis based on the literature from 2001 to 2024: A bibliometric and visualized analysis |
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