Transforming growth factor-beta 1 inhibits casein secretion from differentiating mammary-gland explants but not from lactating mammary cells

Transforming growth factor-beta (TGF beta) is important in the maturation and function of the mammary gland and is present in milk. We have examined whether, in addition to inhibiting lactogenesis, TGF beta exerts acute regulatory effects on lactating mammary cells. The isoform TGF beta 1 at 5 and 5...

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Veröffentlicht in:	Biochemical journal 1994-12, Vol.304 (2), p.333-336
Hauptverfasser:	Sudlow, A.W, Wilde, C.J, Burgoyne, R.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals casein Caseins - biosynthesis Caseins - metabolism Cell Differentiation cells Culture Techniques explants Female Immunoblotting inhibition lactating females lactation Lactation - physiology mammary glands Mammary Glands, Animal - metabolism Mice Pregnancy regulation secretion Transforming Growth Factor beta - pharmacology transforming growth factors
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