A novel micropeptide, Slitharin, exerts cardioprotective effects in myocardial infarction

Purpose: Micropeptides are an emerging class of proteins that play critical roles in cell signaling. Here, we describe the discovery of a novel micropeptide, dubbed slitharin (Slt), in conditioned media from Cardiosphere‐derived cells (CDCs), a therapeutic cardiac stromal cell type. Experimental des...

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Veröffentlicht in:	Proteomics. Clinical applications 2024-09, Vol.18 (5), p.e2300128-n/a
Hauptverfasser:	Ibrahim, Ahmed G. E., Ciullo, Alessandra, Yamaguchi, Shukuro, Li, Chang, Antes, Travis, Jones, Xaviar, Li, Liang, Murali, Ramachandran, Maslennikov, Innokentiy, Sundararaman, Niveda, Soetkamp, Daniel, Cingolani, Eugenio, Van Eyk, Jennifer, Marbán, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Cardiac muscle Cardiomyocytes cardiosphere‐derived cells Cardiotonic Agents - pharmacology Cell signaling Design of experiments Heart Heart attacks Humans Hypoxia Injuries Injury analysis Leucine Male MAP kinase Mass spectrometry Mass spectroscopy micropeptide Myocardial infarction Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocytes Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Neonates Peptides Peptides - pharmacology Rats Rats, Sprague-Dawley Transcriptomics Ventricle
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