Infiltrating Ductal Breast Carcinoma in a Male Patient With Associated BARD1 Mutation
Male breast cancer is an uncommon diagnosis with limited research on management and prognosis due to its rarity. We discuss a case of a 55-year-old male with a non-contributory past medical history who presented with an enlarging palpable mass of his right breast tissue at the 10:00 position. The ul...
Gespeichert in:
| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2024-08, Vol.16 (8), p.e66216 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | e66216 |
| container_title | Curēus (Palo Alto, CA) |
| container_volume | 16 |
| creator | McGrath, Joseph Rhatigan, Dillin J Donahue, Danielle Fannin, Mackenzie Lawson, Nuria |
| description | Male breast cancer is an uncommon diagnosis with limited research on management and prognosis due to its rarity. We discuss a case of a 55-year-old male with a non-contributory past medical history who presented with an enlarging palpable mass of his right breast tissue at the 10:00 position. The ultrasound of the right breast showed a 2.8 cm heterogenous mass with irregular borders highly suspicious for malignancy. The follow-up sonogram-guided core biopsy was performed, and the pathology of the mass confirmed high-grade infiltrating ductal carcinoma. A modified radical mastectomy of the right breast with extensive axillary lymph node excision was performed. Genetic testing of the excised tumor revealed a MUTYH gene mutation and a BARD1 (BRCA1-associated RING domain 1) gene mutation of unknown significance. Histopathological analysis confirmed a Grade 2, ER/PR-positive, KI 67-positive, and HER2-negative tumor. |
| doi_str_mv | 10.7759/cureus.66216 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11374429</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3100918380</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-250cb8e97f57f2164d840117495689abcd8f3548be01256813b437d18f1093ce3</originalsourceid><addsrcrecordid>eNpdkUFLJDEQhYMoKurNswS8eHC00kl3kpOMo66CoojiMaTTaY30JJqkhf33G3dU1EtVUfXxeMVDaJvAAee1PDRjtGM6aJqKNEtovVQxEUSw5W_zGtpK6RkACPAKOKyiNSorSiWr1tH9he_dkKPOzj_ik9FkPeDjaHXKeKajcT7MNXYea3ylB4tvCmh9xg8uP-FpSsE4nW2Hj6e3JwRfjbncg99EK70ekt366Bvo_uz0bnY-ubz-czGbXk4MBciTqgbTCit5X_O--GWdYEAIZ7JuhNSt6URPayZaC6QqK0JbRnlHRE9AUmPpBjpa6L6M7dx2pjiLelAv0c11_KuCdurnxbsn9RjeFCGUM1bJorD3oRDD62hTVnOXjB0G7W0Yk6IEQBJBBRR09xf6HMboy3-FeheUtWgKtb-gTAwpRdt_uSGg3jNTi8zU_8wKvvP9gy_4MyH6D2-3kWk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3111379586</pqid></control><display><type>article</type><title>Infiltrating Ductal Breast Carcinoma in a Male Patient With Associated BARD1 Mutation</title><source>Open Access: PubMed Central</source><source>PubMed Central Open Access</source><creator>McGrath, Joseph ; Rhatigan, Dillin J ; Donahue, Danielle ; Fannin, Mackenzie ; Lawson, Nuria</creator><creatorcontrib>McGrath, Joseph ; Rhatigan, Dillin J ; Donahue, Danielle ; Fannin, Mackenzie ; Lawson, Nuria</creatorcontrib><description>Male breast cancer is an uncommon diagnosis with limited research on management and prognosis due to its rarity. We discuss a case of a 55-year-old male with a non-contributory past medical history who presented with an enlarging palpable mass of his right breast tissue at the 10:00 position. The ultrasound of the right breast showed a 2.8 cm heterogenous mass with irregular borders highly suspicious for malignancy. The follow-up sonogram-guided core biopsy was performed, and the pathology of the mass confirmed high-grade infiltrating ductal carcinoma. A modified radical mastectomy of the right breast with extensive axillary lymph node excision was performed. Genetic testing of the excised tumor revealed a MUTYH gene mutation and a BARD1 (BRCA1-associated RING domain 1) gene mutation of unknown significance. Histopathological analysis confirmed a Grade 2, ER/PR-positive, KI 67-positive, and HER2-negative tumor.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.66216</identifier><identifier>PMID: 39233942</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Breast cancer ; Case reports ; Females ; General Surgery ; Genetics ; Mutation ; Oncology ; Ovarian cancer</subject><ispartof>Curēus (Palo Alto, CA), 2024-08, Vol.16 (8), p.e66216</ispartof><rights>Copyright © 2024, McGrath et al.</rights><rights>Copyright © 2024, McGrath et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2024, McGrath et al. 2024 McGrath et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-250cb8e97f57f2164d840117495689abcd8f3548be01256813b437d18f1093ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374429/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374429/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39233942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McGrath, Joseph</creatorcontrib><creatorcontrib>Rhatigan, Dillin J</creatorcontrib><creatorcontrib>Donahue, Danielle</creatorcontrib><creatorcontrib>Fannin, Mackenzie</creatorcontrib><creatorcontrib>Lawson, Nuria</creatorcontrib><title>Infiltrating Ductal Breast Carcinoma in a Male Patient With Associated BARD1 Mutation</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Male breast cancer is an uncommon diagnosis with limited research on management and prognosis due to its rarity. We discuss a case of a 55-year-old male with a non-contributory past medical history who presented with an enlarging palpable mass of his right breast tissue at the 10:00 position. The ultrasound of the right breast showed a 2.8 cm heterogenous mass with irregular borders highly suspicious for malignancy. The follow-up sonogram-guided core biopsy was performed, and the pathology of the mass confirmed high-grade infiltrating ductal carcinoma. A modified radical mastectomy of the right breast with extensive axillary lymph node excision was performed. Genetic testing of the excised tumor revealed a MUTYH gene mutation and a BARD1 (BRCA1-associated RING domain 1) gene mutation of unknown significance. Histopathological analysis confirmed a Grade 2, ER/PR-positive, KI 67-positive, and HER2-negative tumor.</description><subject>Breast cancer</subject><subject>Case reports</subject><subject>Females</subject><subject>General Surgery</subject><subject>Genetics</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Ovarian cancer</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkUFLJDEQhYMoKurNswS8eHC00kl3kpOMo66CoojiMaTTaY30JJqkhf33G3dU1EtVUfXxeMVDaJvAAee1PDRjtGM6aJqKNEtovVQxEUSw5W_zGtpK6RkACPAKOKyiNSorSiWr1tH9he_dkKPOzj_ik9FkPeDjaHXKeKajcT7MNXYea3ylB4tvCmh9xg8uP-FpSsE4nW2Hj6e3JwRfjbncg99EK70ekt366Bvo_uz0bnY-ubz-czGbXk4MBciTqgbTCit5X_O--GWdYEAIZ7JuhNSt6URPayZaC6QqK0JbRnlHRE9AUmPpBjpa6L6M7dx2pjiLelAv0c11_KuCdurnxbsn9RjeFCGUM1bJorD3oRDD62hTVnOXjB0G7W0Yk6IEQBJBBRR09xf6HMboy3-FeheUtWgKtb-gTAwpRdt_uSGg3jNTi8zU_8wKvvP9gy_4MyH6D2-3kWk</recordid><startdate>20240805</startdate><enddate>20240805</enddate><creator>McGrath, Joseph</creator><creator>Rhatigan, Dillin J</creator><creator>Donahue, Danielle</creator><creator>Fannin, Mackenzie</creator><creator>Lawson, Nuria</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240805</creationdate><title>Infiltrating Ductal Breast Carcinoma in a Male Patient With Associated BARD1 Mutation</title><author>McGrath, Joseph ; Rhatigan, Dillin J ; Donahue, Danielle ; Fannin, Mackenzie ; Lawson, Nuria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-250cb8e97f57f2164d840117495689abcd8f3548be01256813b437d18f1093ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Breast cancer</topic><topic>Case reports</topic><topic>Females</topic><topic>General Surgery</topic><topic>Genetics</topic><topic>Mutation</topic><topic>Oncology</topic><topic>Ovarian cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McGrath, Joseph</creatorcontrib><creatorcontrib>Rhatigan, Dillin J</creatorcontrib><creatorcontrib>Donahue, Danielle</creatorcontrib><creatorcontrib>Fannin, Mackenzie</creatorcontrib><creatorcontrib>Lawson, Nuria</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McGrath, Joseph</au><au>Rhatigan, Dillin J</au><au>Donahue, Danielle</au><au>Fannin, Mackenzie</au><au>Lawson, Nuria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infiltrating Ductal Breast Carcinoma in a Male Patient With Associated BARD1 Mutation</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2024-08-05</date><risdate>2024</risdate><volume>16</volume><issue>8</issue><spage>e66216</spage><pages>e66216-</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Male breast cancer is an uncommon diagnosis with limited research on management and prognosis due to its rarity. We discuss a case of a 55-year-old male with a non-contributory past medical history who presented with an enlarging palpable mass of his right breast tissue at the 10:00 position. The ultrasound of the right breast showed a 2.8 cm heterogenous mass with irregular borders highly suspicious for malignancy. The follow-up sonogram-guided core biopsy was performed, and the pathology of the mass confirmed high-grade infiltrating ductal carcinoma. A modified radical mastectomy of the right breast with extensive axillary lymph node excision was performed. Genetic testing of the excised tumor revealed a MUTYH gene mutation and a BARD1 (BRCA1-associated RING domain 1) gene mutation of unknown significance. Histopathological analysis confirmed a Grade 2, ER/PR-positive, KI 67-positive, and HER2-negative tumor.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>39233942</pmid><doi>10.7759/cureus.66216</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2168-8184 |
| ispartof | Curēus (Palo Alto, CA), 2024-08, Vol.16 (8), p.e66216 |
| issn | 2168-8184 2168-8184 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11374429 |
| source | Open Access: PubMed Central; PubMed Central Open Access |
| subjects | Breast cancer Case reports Females General Surgery Genetics Mutation Oncology Ovarian cancer |
| title | Infiltrating Ductal Breast Carcinoma in a Male Patient With Associated BARD1 Mutation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T17%3A59%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Infiltrating%20Ductal%20Breast%20Carcinoma%20in%20a%20Male%20Patient%20With%20Associated%20BARD1%20Mutation&rft.jtitle=Cur%C4%93us%20(Palo%20Alto,%20CA)&rft.au=McGrath,%20Joseph&rft.date=2024-08-05&rft.volume=16&rft.issue=8&rft.spage=e66216&rft.pages=e66216-&rft.issn=2168-8184&rft.eissn=2168-8184&rft_id=info:doi/10.7759/cureus.66216&rft_dat=%3Cproquest_pubme%3E3100918380%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3111379586&rft_id=info:pmid/39233942&rfr_iscdi=true |