A random mutagenesis screen enriched for missense mutations in bacterial effector proteins

Abstract To remodel their hosts and escape immune defenses, many pathogens rely on large arsenals of proteins (effectors) that are delivered to the host cell using dedicated translocation machinery. Effectors hold significant insight into the biology of both the pathogens that encode them and the ho...

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Veröffentlicht in:	G3 : genes - genomes - genetics 2024-09, Vol.14 (9)
Hauptverfasser:	Urbanus, Malene L, Zheng, Thomas M, Khusnutdinova, Anna N, Banh, Doreen, O’Connor Mount, Harley, Gupta, Alind, Stogios, Peter J, Savchenko, Alexei, Isberg, Ralph R, Yakunin, Alexander F, Ensminger, Alexander W
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - metabolism Investigation Legionella pneumophila - genetics Legionella pneumophila - metabolism Models, Molecular Mutagenesis Mutation, Missense Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism
Online-Zugang:	Volltext
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