Mechanistic differences between linear vs. spirocyclic dialkyldiazirine probes for photoaffinity labeling

Dialkyldiazirines have emerged as a photo-reactive group of choice for interactome mapping in live cell experiments. Upon irradiation, 'linear' dialkyldiazirines produce dialkylcarbenes which are susceptible to both intramolecular reactions and unimolecular elimination processes, as well a...

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Veröffentlicht in:	Chemical science (Cambridge) 2024-08, Vol.15 (37), p.15463-15473
Hauptverfasser:	O'Brien, Jessica G K, Conway, Louis P, Ramaraj, Paramesh K, Jadhav, Appaso M, Jin, Jun, Dutra, Jason K, Evers, Parrish, Masoud, Shadi S, Schupp, Manuel, Saridakis, Iakovos, Chen, Yong, Maulide, Nuno, Pezacki, John P, Am Ende, Christopher W, Parker, Christopher G, Fox, Joseph M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Carbenes Chemistry Cycloaddition Decomposition reactions Labeling Low temperature Photolysis Proteins
Online-Zugang:	Volltext
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