Occurrence of two molecular forms of human acid sphingomyelinase

Human acid sphingomyelinase (ASM) hydrolyses sphingomyelin to ceramide and phosphocholine. Metabolic studies on COS-1 cells transfected with ASM cDNA revealed the occurrence of an enzymically inactive precursor which is differentially processed to two predominant native glycoprotein forms: a 70 kDa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical journal 1994-08, Vol.301 (3), p.855-862
Hauptverfasser:	FERLINZ, K, HURWITZ, R, VIELHABER, G, SUZUKI, K, SANDHOFF, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Base Sequence Biological and medical sciences Cell Line DNA, Complementary - genetics Enzyme Precursors - metabolism Enzymes and enzyme inhibitors Escherichia coli - genetics Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Glycosylation Humans Hydrogen-Ion Concentration Hydrolases Mannose - metabolism Methionine - metabolism Molecular Sequence Data Molecular Weight Mutagenesis Organelles - metabolism Protein Processing, Post-Translational RNA, Messenger - metabolism Sphingomyelin Phosphodiesterase - analysis Sphingomyelin Phosphodiesterase - biosynthesis Sphingomyelin Phosphodiesterase - genetics Sulfur Radioisotopes Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!