Ascorbic acid increases drug accumulation and reverses vincristine resistance of human non-small-cell lung-cancer cells

A human lung-cancer PC-9 subline with acquired resistance to vincristine (VCR), a chemotherapeutic agent, was established with incremental increases of the drug. The resistant PC-9 subline (PC-9/VCR) shows a 12-fold increase in resistance to VCR and a unique cross-resistance pattern: high cross-resi...

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Veröffentlicht in:	Biochemical journal 1994-08, Vol.301 (3), p.759-764
Hauptverfasser:	CHI DER CHIANG, EING-JU SONG, VIE CHENG YANG, CHAO, C. C.-K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Ascorbic Acid - pharmacology ATP Binding Cassette Transporter, Subfamily B, Member 1 Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carrier Proteins - genetics Carrier Proteins - physiology Cisplatin - therapeutic use Colchicine - therapeutic use Dactinomycin - therapeutic use Doxorubicin - therapeutic use Drug Resistance - genetics Gene Expression General aspects Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Pharmacology. Drug treatments Tumor Cells, Cultured Vinblastine - therapeutic use Vincristine - metabolism Vincristine - therapeutic use
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