Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer

Activation in transformed cells of normal stem cells' self-renewal pathways might contribute to the survival life cycle of cancer stem cells and promote tumor progression. The BMI-1 oncogene-driven gene expression pathway is essential for the self-renewal of hematopoietic and neural stem cells....

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Veröffentlicht in:	The Journal of clinical investigation 2005-06, Vol.115 (6), p.1503-1521
Hauptverfasser:	Glinsky, Gennadi V, Berezovska, Olga, Glinskii, Anna B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical research Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Leukemia Lung cancer Male Medical prognosis Metastasis Mice Mice, Transgenic Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Nuclear Proteins - genetics Nuclear Proteins - metabolism Oligonucleotide Array Sequence Analysis Polycomb Repressive Complex 1 Prognosis Prostate cancer Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Stem cells Tumors
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