The antibiotic resistance profiles of Pseudomonas aeruginosa in the Asia Cornea Society Infectious Keratitis Study
Purpose To describe the prevalence and antibiotic resistance profiles of Pseudomonas aeruginosa isolated from the Asia Cornea Society Infectious Keratitis Study (ACSIKS). Methods All bacterial isolates from ACSIKS underwent repeat microbiological identification in a central repository in Singapore....
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| Veröffentlicht in: | International ophthalmology 2024-08, Vol.44 (1), p.361, Article 361 |
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| creator | Khor, Wei-Boon Lakshminarayanan, Rajamani Periayah, Mercy Halleluyah Prajna, Venkatesh N. Garg, Prashant Sharma, Namrata Mehta, Jodhbir S. Young, Alvin Goseyarakwong, Panida Puangsricharern, Vilavun Tan, Ai Ling Beuerman, Roger W. Tan, Donald Tiang-Hwee |
| description | Purpose
To describe the prevalence and antibiotic resistance profiles of
Pseudomonas
aeruginosa
isolated from the Asia Cornea Society Infectious Keratitis Study (ACSIKS).
Methods
All bacterial isolates from ACSIKS underwent repeat microbiological identification in a central repository in Singapore. Minimum inhibitory concentration (MIC) determination was conducted for isolates of
P. aeruginosa
against thirteen antibiotics from 6 different classes, and categorized based on Clinical Laboratory Standard Institutes’ reference ranges. The percentage rates of resistance (non-susceptibility) to each antibiotic included isolates of both intermediate and complete resistance. Multi-drug resistance (MDR) was defined as non-susceptibility to at least one agent in three or more antimicrobial classes.
Results
Of the 1493 unique bacterial specimens obtained from ACSIKS, 319 isolates were of
P. aeruginosa.
The majority of isolates were from centers in India (n = 118, 37%), Singapore (n = 90, 28.2%), Hong Kong (n = 31, 9.7%) and Thailand (n = 30, 9.4%). The cumulative antibiotic resistance rate was the greatest for polymyxin B (100%), ciprofloxacin (17.6%) and moxifloxacin (16.9%), and lowest for cefepime (11.6%) and amikacin (13.5%). Isolates from India demonstrated the highest antibiotic resistance rates of all the centers, and included moxifloxacin (47.5%) and ciprofloxacin (39.8%). Forty-eight of the 59 MDR isolates also originated from India. Antibiotic resistance rates were significantly lower in the other ACSIKS centers, and were typically less than 10%.
Conclusions
The antibiotic resistance profiles of
P. aeruginosa
varied between different countries. While it was low for most countries, substantial antibiotic resistance and a significant number of multi-drug resistant isolates were noted in the centers from India. |
| doi_str_mv | 10.1007/s10792-024-03270-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11365837</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3099807188</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-a866afcfb5fa0dead2dc715259e4429b1502ded040040594d270c362ffc815493</originalsourceid><addsrcrecordid>eNp9kV1rFTEQhoNYbK3-AS8k4I03a_Ox2d1cSTn4USxUaL0OOdnJacqe5JjJFvbfG3tqrb0QAgnMM-_Mm5eQN5x94Iz1J8hZr0XDRNswKXrWLM_IEVe9bEQn2fNH70PyEvGGMaZ73b0gh1ILrgYlj0i-ugZqYwnrkEpwNAMGLDY6oLucfJgAafL0O8I8pm2KFqmFPG9CTGhpiLTU_lMMlq5SjmDpZXIBykLPogdXQpqRfoNsSygB6WWZx-UVOfB2Qnh9fx-TH58_Xa2-NucXX85Wp-eNk6orjR26znrn18pbNoIdxeh6roTS0LZCr7liYoSRtawepdux_oCTnfDeDVy1Wh6Tj3vd3bzewugglmwns8tha_Nikg3m30oM12aTbg3nslOD7KvC-3uFnH7OgMVsAzqYJhuhGjOSaT2wng9DRd89QW_SnGP1d0dxreqSlRJ7yuWEmME_bMOZ-Z2p2WdqaqbmLlOz1Ka3j308tPwJsQJyD2AtxQ3kv7P_I_sLUs-vfA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3099195405</pqid></control><display><type>article</type><title>The antibiotic resistance profiles of Pseudomonas aeruginosa in the Asia Cornea Society Infectious Keratitis Study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Khor, Wei-Boon ; Lakshminarayanan, Rajamani ; Periayah, Mercy Halleluyah ; Prajna, Venkatesh N. ; Garg, Prashant ; Sharma, Namrata ; Mehta, Jodhbir S. ; Young, Alvin ; Goseyarakwong, Panida ; Puangsricharern, Vilavun ; Tan, Ai Ling ; Beuerman, Roger W. ; Tan, Donald Tiang-Hwee</creator><creatorcontrib>Khor, Wei-Boon ; Lakshminarayanan, Rajamani ; Periayah, Mercy Halleluyah ; Prajna, Venkatesh N. ; Garg, Prashant ; Sharma, Namrata ; Mehta, Jodhbir S. ; Young, Alvin ; Goseyarakwong, Panida ; Puangsricharern, Vilavun ; Tan, Ai Ling ; Beuerman, Roger W. ; Tan, Donald Tiang-Hwee ; ACSIKS GROUP ; for the ACSIKS GROUP</creatorcontrib><description>Purpose
To describe the prevalence and antibiotic resistance profiles of
Pseudomonas
aeruginosa
isolated from the Asia Cornea Society Infectious Keratitis Study (ACSIKS).
Methods
All bacterial isolates from ACSIKS underwent repeat microbiological identification in a central repository in Singapore. Minimum inhibitory concentration (MIC) determination was conducted for isolates of
P. aeruginosa
against thirteen antibiotics from 6 different classes, and categorized based on Clinical Laboratory Standard Institutes’ reference ranges. The percentage rates of resistance (non-susceptibility) to each antibiotic included isolates of both intermediate and complete resistance. Multi-drug resistance (MDR) was defined as non-susceptibility to at least one agent in three or more antimicrobial classes.
Results
Of the 1493 unique bacterial specimens obtained from ACSIKS, 319 isolates were of
P. aeruginosa.
The majority of isolates were from centers in India (n = 118, 37%), Singapore (n = 90, 28.2%), Hong Kong (n = 31, 9.7%) and Thailand (n = 30, 9.4%). The cumulative antibiotic resistance rate was the greatest for polymyxin B (100%), ciprofloxacin (17.6%) and moxifloxacin (16.9%), and lowest for cefepime (11.6%) and amikacin (13.5%). Isolates from India demonstrated the highest antibiotic resistance rates of all the centers, and included moxifloxacin (47.5%) and ciprofloxacin (39.8%). Forty-eight of the 59 MDR isolates also originated from India. Antibiotic resistance rates were significantly lower in the other ACSIKS centers, and were typically less than 10%.
Conclusions
The antibiotic resistance profiles of
P. aeruginosa
varied between different countries. While it was low for most countries, substantial antibiotic resistance and a significant number of multi-drug resistant isolates were noted in the centers from India.</description><identifier>ISSN: 1573-2630</identifier><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-024-03270-y</identifier><identifier>PMID: 39215853</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Amikacin ; Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Antibiotics ; Cefepime ; Ciprofloxacin ; Cornea ; Corneal Ulcer - drug therapy ; Corneal Ulcer - epidemiology ; Corneal Ulcer - microbiology ; Drug resistance ; Drug Resistance, Bacterial ; Eye Infections, Bacterial - drug therapy ; Eye Infections, Bacterial - epidemiology ; Eye Infections, Bacterial - microbiology ; Female ; Humans ; Keratitis ; Keratitis - drug therapy ; Keratitis - epidemiology ; Keratitis - microbiology ; Male ; Medicine ; Medicine & Public Health ; Microbial Sensitivity Tests ; Minimum inhibitory concentration ; Moxifloxacin ; Multidrug resistance ; Ophthalmology ; Original Paper ; Polymyxin B ; Prevalence ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects ; Pseudomonas aeruginosa - isolation & purification ; Pseudomonas Infections - drug therapy ; Pseudomonas Infections - epidemiology ; Pseudomonas Infections - microbiology ; Societies, Medical</subject><ispartof>International ophthalmology, 2024-08, Vol.44 (1), p.361, Article 361</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-a866afcfb5fa0dead2dc715259e4429b1502ded040040594d270c362ffc815493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-024-03270-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-024-03270-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39215853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khor, Wei-Boon</creatorcontrib><creatorcontrib>Lakshminarayanan, Rajamani</creatorcontrib><creatorcontrib>Periayah, Mercy Halleluyah</creatorcontrib><creatorcontrib>Prajna, Venkatesh N.</creatorcontrib><creatorcontrib>Garg, Prashant</creatorcontrib><creatorcontrib>Sharma, Namrata</creatorcontrib><creatorcontrib>Mehta, Jodhbir S.</creatorcontrib><creatorcontrib>Young, Alvin</creatorcontrib><creatorcontrib>Goseyarakwong, Panida</creatorcontrib><creatorcontrib>Puangsricharern, Vilavun</creatorcontrib><creatorcontrib>Tan, Ai Ling</creatorcontrib><creatorcontrib>Beuerman, Roger W.</creatorcontrib><creatorcontrib>Tan, Donald Tiang-Hwee</creatorcontrib><creatorcontrib>ACSIKS GROUP</creatorcontrib><creatorcontrib>for the ACSIKS GROUP</creatorcontrib><title>The antibiotic resistance profiles of Pseudomonas aeruginosa in the Asia Cornea Society Infectious Keratitis Study</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To describe the prevalence and antibiotic resistance profiles of
Pseudomonas
aeruginosa
isolated from the Asia Cornea Society Infectious Keratitis Study (ACSIKS).
Methods
All bacterial isolates from ACSIKS underwent repeat microbiological identification in a central repository in Singapore. Minimum inhibitory concentration (MIC) determination was conducted for isolates of
P. aeruginosa
against thirteen antibiotics from 6 different classes, and categorized based on Clinical Laboratory Standard Institutes’ reference ranges. The percentage rates of resistance (non-susceptibility) to each antibiotic included isolates of both intermediate and complete resistance. Multi-drug resistance (MDR) was defined as non-susceptibility to at least one agent in three or more antimicrobial classes.
Results
Of the 1493 unique bacterial specimens obtained from ACSIKS, 319 isolates were of
P. aeruginosa.
The majority of isolates were from centers in India (n = 118, 37%), Singapore (n = 90, 28.2%), Hong Kong (n = 31, 9.7%) and Thailand (n = 30, 9.4%). The cumulative antibiotic resistance rate was the greatest for polymyxin B (100%), ciprofloxacin (17.6%) and moxifloxacin (16.9%), and lowest for cefepime (11.6%) and amikacin (13.5%). Isolates from India demonstrated the highest antibiotic resistance rates of all the centers, and included moxifloxacin (47.5%) and ciprofloxacin (39.8%). Forty-eight of the 59 MDR isolates also originated from India. Antibiotic resistance rates were significantly lower in the other ACSIKS centers, and were typically less than 10%.
Conclusions
The antibiotic resistance profiles of
P. aeruginosa
varied between different countries. While it was low for most countries, substantial antibiotic resistance and a significant number of multi-drug resistant isolates were noted in the centers from India.</description><subject>Amikacin</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Cefepime</subject><subject>Ciprofloxacin</subject><subject>Cornea</subject><subject>Corneal Ulcer - drug therapy</subject><subject>Corneal Ulcer - epidemiology</subject><subject>Corneal Ulcer - microbiology</subject><subject>Drug resistance</subject><subject>Drug Resistance, Bacterial</subject><subject>Eye Infections, Bacterial - drug therapy</subject><subject>Eye Infections, Bacterial - epidemiology</subject><subject>Eye Infections, Bacterial - microbiology</subject><subject>Female</subject><subject>Humans</subject><subject>Keratitis</subject><subject>Keratitis - drug therapy</subject><subject>Keratitis - epidemiology</subject><subject>Keratitis - microbiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microbial Sensitivity Tests</subject><subject>Minimum inhibitory concentration</subject><subject>Moxifloxacin</subject><subject>Multidrug resistance</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Polymyxin B</subject><subject>Prevalence</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Pseudomonas aeruginosa - isolation & purification</subject><subject>Pseudomonas Infections - drug therapy</subject><subject>Pseudomonas Infections - epidemiology</subject><subject>Pseudomonas Infections - microbiology</subject><subject>Societies, Medical</subject><issn>1573-2630</issn><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kV1rFTEQhoNYbK3-AS8k4I03a_Ox2d1cSTn4USxUaL0OOdnJacqe5JjJFvbfG3tqrb0QAgnMM-_Mm5eQN5x94Iz1J8hZr0XDRNswKXrWLM_IEVe9bEQn2fNH70PyEvGGMaZ73b0gh1ILrgYlj0i-ugZqYwnrkEpwNAMGLDY6oLucfJgAafL0O8I8pm2KFqmFPG9CTGhpiLTU_lMMlq5SjmDpZXIBykLPogdXQpqRfoNsSygB6WWZx-UVOfB2Qnh9fx-TH58_Xa2-NucXX85Wp-eNk6orjR26znrn18pbNoIdxeh6roTS0LZCr7liYoSRtawepdux_oCTnfDeDVy1Wh6Tj3vd3bzewugglmwns8tha_Nikg3m30oM12aTbg3nslOD7KvC-3uFnH7OgMVsAzqYJhuhGjOSaT2wng9DRd89QW_SnGP1d0dxreqSlRJ7yuWEmME_bMOZ-Z2p2WdqaqbmLlOz1Ka3j308tPwJsQJyD2AtxQ3kv7P_I_sLUs-vfA</recordid><startdate>20240831</startdate><enddate>20240831</enddate><creator>Khor, Wei-Boon</creator><creator>Lakshminarayanan, Rajamani</creator><creator>Periayah, Mercy Halleluyah</creator><creator>Prajna, Venkatesh N.</creator><creator>Garg, Prashant</creator><creator>Sharma, Namrata</creator><creator>Mehta, Jodhbir S.</creator><creator>Young, Alvin</creator><creator>Goseyarakwong, Panida</creator><creator>Puangsricharern, Vilavun</creator><creator>Tan, Ai Ling</creator><creator>Beuerman, Roger W.</creator><creator>Tan, Donald Tiang-Hwee</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240831</creationdate><title>The antibiotic resistance profiles of Pseudomonas aeruginosa in the Asia Cornea Society Infectious Keratitis Study</title><author>Khor, Wei-Boon ; Lakshminarayanan, Rajamani ; Periayah, Mercy Halleluyah ; Prajna, Venkatesh N. ; Garg, Prashant ; Sharma, Namrata ; Mehta, Jodhbir S. ; Young, Alvin ; Goseyarakwong, Panida ; Puangsricharern, Vilavun ; Tan, Ai Ling ; Beuerman, Roger W. ; Tan, Donald Tiang-Hwee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-a866afcfb5fa0dead2dc715259e4429b1502ded040040594d270c362ffc815493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Amikacin</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Cefepime</topic><topic>Ciprofloxacin</topic><topic>Cornea</topic><topic>Corneal Ulcer - drug therapy</topic><topic>Corneal Ulcer - epidemiology</topic><topic>Corneal Ulcer - microbiology</topic><topic>Drug resistance</topic><topic>Drug Resistance, Bacterial</topic><topic>Eye Infections, Bacterial - drug therapy</topic><topic>Eye Infections, Bacterial - epidemiology</topic><topic>Eye Infections, Bacterial - microbiology</topic><topic>Female</topic><topic>Humans</topic><topic>Keratitis</topic><topic>Keratitis - drug therapy</topic><topic>Keratitis - epidemiology</topic><topic>Keratitis - microbiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microbial Sensitivity Tests</topic><topic>Minimum inhibitory concentration</topic><topic>Moxifloxacin</topic><topic>Multidrug resistance</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Polymyxin B</topic><topic>Prevalence</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Pseudomonas aeruginosa - isolation & purification</topic><topic>Pseudomonas Infections - drug therapy</topic><topic>Pseudomonas Infections - epidemiology</topic><topic>Pseudomonas Infections - microbiology</topic><topic>Societies, Medical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khor, Wei-Boon</creatorcontrib><creatorcontrib>Lakshminarayanan, Rajamani</creatorcontrib><creatorcontrib>Periayah, Mercy Halleluyah</creatorcontrib><creatorcontrib>Prajna, Venkatesh N.</creatorcontrib><creatorcontrib>Garg, Prashant</creatorcontrib><creatorcontrib>Sharma, Namrata</creatorcontrib><creatorcontrib>Mehta, Jodhbir S.</creatorcontrib><creatorcontrib>Young, Alvin</creatorcontrib><creatorcontrib>Goseyarakwong, Panida</creatorcontrib><creatorcontrib>Puangsricharern, Vilavun</creatorcontrib><creatorcontrib>Tan, Ai Ling</creatorcontrib><creatorcontrib>Beuerman, Roger W.</creatorcontrib><creatorcontrib>Tan, Donald Tiang-Hwee</creatorcontrib><creatorcontrib>ACSIKS GROUP</creatorcontrib><creatorcontrib>for the ACSIKS GROUP</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khor, Wei-Boon</au><au>Lakshminarayanan, Rajamani</au><au>Periayah, Mercy Halleluyah</au><au>Prajna, Venkatesh N.</au><au>Garg, Prashant</au><au>Sharma, Namrata</au><au>Mehta, Jodhbir S.</au><au>Young, Alvin</au><au>Goseyarakwong, Panida</au><au>Puangsricharern, Vilavun</au><au>Tan, Ai Ling</au><au>Beuerman, Roger W.</au><au>Tan, Donald Tiang-Hwee</au><aucorp>ACSIKS GROUP</aucorp><aucorp>for the ACSIKS GROUP</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The antibiotic resistance profiles of Pseudomonas aeruginosa in the Asia Cornea Society Infectious Keratitis Study</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2024-08-31</date><risdate>2024</risdate><volume>44</volume><issue>1</issue><spage>361</spage><pages>361-</pages><artnum>361</artnum><issn>1573-2630</issn><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To describe the prevalence and antibiotic resistance profiles of
Pseudomonas
aeruginosa
isolated from the Asia Cornea Society Infectious Keratitis Study (ACSIKS).
Methods
All bacterial isolates from ACSIKS underwent repeat microbiological identification in a central repository in Singapore. Minimum inhibitory concentration (MIC) determination was conducted for isolates of
P. aeruginosa
against thirteen antibiotics from 6 different classes, and categorized based on Clinical Laboratory Standard Institutes’ reference ranges. The percentage rates of resistance (non-susceptibility) to each antibiotic included isolates of both intermediate and complete resistance. Multi-drug resistance (MDR) was defined as non-susceptibility to at least one agent in three or more antimicrobial classes.
Results
Of the 1493 unique bacterial specimens obtained from ACSIKS, 319 isolates were of
P. aeruginosa.
The majority of isolates were from centers in India (n = 118, 37%), Singapore (n = 90, 28.2%), Hong Kong (n = 31, 9.7%) and Thailand (n = 30, 9.4%). The cumulative antibiotic resistance rate was the greatest for polymyxin B (100%), ciprofloxacin (17.6%) and moxifloxacin (16.9%), and lowest for cefepime (11.6%) and amikacin (13.5%). Isolates from India demonstrated the highest antibiotic resistance rates of all the centers, and included moxifloxacin (47.5%) and ciprofloxacin (39.8%). Forty-eight of the 59 MDR isolates also originated from India. Antibiotic resistance rates were significantly lower in the other ACSIKS centers, and were typically less than 10%.
Conclusions
The antibiotic resistance profiles of
P. aeruginosa
varied between different countries. While it was low for most countries, substantial antibiotic resistance and a significant number of multi-drug resistant isolates were noted in the centers from India.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>39215853</pmid><doi>10.1007/s10792-024-03270-y</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | International ophthalmology, 2024-08, Vol.44 (1), p.361, Article 361 |
| issn | 1573-2630 0165-5701 1573-2630 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Amikacin Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Cefepime Ciprofloxacin Cornea Corneal Ulcer - drug therapy Corneal Ulcer - epidemiology Corneal Ulcer - microbiology Drug resistance Drug Resistance, Bacterial Eye Infections, Bacterial - drug therapy Eye Infections, Bacterial - epidemiology Eye Infections, Bacterial - microbiology Female Humans Keratitis Keratitis - drug therapy Keratitis - epidemiology Keratitis - microbiology Male Medicine Medicine & Public Health Microbial Sensitivity Tests Minimum inhibitory concentration Moxifloxacin Multidrug resistance Ophthalmology Original Paper Polymyxin B Prevalence Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - drug therapy Pseudomonas Infections - epidemiology Pseudomonas Infections - microbiology Societies, Medical |
| title | The antibiotic resistance profiles of Pseudomonas aeruginosa in the Asia Cornea Society Infectious Keratitis Study |
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