The effect of romosozumab on bone mineral density depending on prior treatment: a prospective, multicentre cohort study in Switzerland

Summary This multicentre, prospective cohort study measured the effect of romosozumab for 12 months on bone mineral density, taking into account prior therapies. Prior antiresorptive therapy blunted the BMD response to romosozumab, and the duration was correlated with BMD changes at both the lumbar...

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Veröffentlicht in:	Osteoporosis international 2024-09, Vol.35 (9), p.1605-1613
Hauptverfasser:	Everts-Graber, Judith, Wenger, Mathias, Oser, Sven, Studer, Ueli, Steiner, Christian, Ziswiler, Hans-Rudolf, Sromek, Karoline, Schmid, Gernot, Gahl, Brigitta, Häuselmann, HansJörg, Reichenbach, Stephan, Lehmann, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon - methods Aged Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Biomarkers - blood Body mass index Bone density Bone Density - drug effects Bone Density - physiology Bone Density Conservation Agents - administration & dosage Bone Density Conservation Agents - pharmacology Bone Density Conservation Agents - therapeutic use Bone mineral density Bone Remodeling - drug effects Bone Remodeling - physiology Bone turnover Cohort analysis Collagen Collagen Type I - blood Endocrinology Female Femur Neck - physiopathology Hip Hip Joint - physiopathology Humans Lumbar Vertebrae - physiopathology Male Medicine Medicine & Public Health Monoclonal antibodies Original Original Article Orthopedics Osteoporosis Osteoporosis - drug therapy Osteoporosis - physiopathology Parathyroid hormone Peptide Fragments - blood Peptides Procollagen - blood Prospective Studies Registries Rheumatology Spine (lumbar) Switzerland
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