Evidence for receptor and G-protein regulation of a phosphatidylethanolamine-hydrolysing phospholipase A1 in guinea-pig heart microsomes: stimulation of phospholipase A1 activity by DL-isoprenaline and guanine nucleotides

While evidence has been presented for the receptor-mediated activation of phospholipases A2, C and D, the activation of phospholipase A1 subsequent to receptor activation has not been established. Phospholipase A1-catalysed hydrolysis of 1-palmitoyl-2-linoleoyl-glycerophosphoethanolamine (GPE) by gu...

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Veröffentlicht in:	Biochemical journal 1995-12, Vol.312 ( Pt 3) (3), p.805-809
Hauptverfasser:	Badiani, K, Arthur, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology Adrenergic beta-Antagonists - pharmacology Animals Butoxamine - pharmacology GTP-Binding Proteins - physiology Guanine Nucleotides - pharmacology Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Guanylyl Imidodiphosphate - pharmacology Guinea Pigs Isoproterenol - pharmacology Microsomes - enzymology Myocardium - enzymology Myocardium - ultrastructure Phosphatidylethanolamines - metabolism Phospholipases A - metabolism Phospholipases A1 Propranolol - pharmacology Receptors, Adrenergic, beta - physiology
Online-Zugang:	Volltext
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