Stimulatory antibody-induced activation and selective translocation of protein kinase C isoenzymes in human platelets

A novel stimulatory monoclonal antibody (Mab) termed Mab.F11 induces granular secretion and subsequent aggregation of human platelets. Mab.F11 recognizes a unique 32 and 35 kDa protein duplex on the platelet membrane surface, called the F11 receptor; binding of Mab.F11 to its receptor results in inc...

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Veröffentlicht in:	Biochemical journal 1995-10, Vol.311 ( Pt 2) (2), p.401-406
Hauptverfasser:	Wang, F, Naik, U P, Ehrlich, Y H, Osada, S, Ohno, S, Kornecki, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Monoclonal - pharmacology Blood Platelets - drug effects Blood Platelets - enzymology Blood Platelets - immunology Electrophoresis, Polyacrylamide Gel Enzyme Activation Humans Immunoblotting Isoenzymes - blood Membrane Proteins - chemistry Membrane Proteins - immunology Molecular Sequence Data Peptide Fragments Phosphorylation Platelet Activation - physiology Platelet Aggregation Platelet Glycoprotein GPIIb-IIIa Complex - physiology Protein Kinase C - blood Receptors, IgG - physiology
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