Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion
Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in cardiovascular diseases. Among immunoglobulins (Ig), IgA, the most abundant mucosal antibody, is produced by plasma B cells in intestinal Peyer's patches (PP) and lamina propria. Here we show that patients...
Gespeichert in:
| Veröffentlicht in: | Nature Cardiovascular Research 2024-05, Vol.3 (5), p.525-540 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 540 |
|---|---|
| container_issue | 5 |
| container_start_page | 525 |
| container_title | Nature Cardiovascular Research |
| container_volume | 3 |
| creator | Tuz, Ali A Ghosh, Susmita Karsch, Laura Ttoouli, Dimitris Sata, Sai P Ulusoy, Özgür Kraus, Andreas Hoerenbaum, Nils Wolf, Jan-Niklas Lohmann, Sabrina Zwirnlein, Franziska Kaygusuz, Viola Lakovic, Vivian Tummes, Hannah-Lea Beer, Alexander Gallert, Markus Thiebes, Stephanie Qefalia, Altea Cibir, Zülal Antler, Medina Korste, Sebastian Haj Yehia, Elias Michel, Lars Rassaf, Tienush Kaltwasser, Britta Abdelrahman, Hossam Mohamud Yusuf, Ayan Wang, Chen Yin, Dongpei Haeusler, Lars Lueong, Smiths Richter, Mathis Engel, Daniel R Stenzel, Martin Soehnlein, Oliver Frank, Benedikt Solo-Nomenjanahary, Mialitiana Ho-Tin-Noé, Benoît Siveke, Jens T Totzeck, Matthias Hoffmann, Daniel Grüneboom, Anika Hagemann, Nina Hasenberg, Anja Desilles, Jean-Philippe Mazighi, Mikael Sickmann, Albert Chen, Jianxu Hermann, Dirk M Gunzer, Matthias Singh, Vikramjeet |
| description | Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in cardiovascular diseases. Among immunoglobulins (Ig), IgA, the most abundant mucosal antibody, is produced by plasma B cells in intestinal Peyer's patches (PP) and lamina propria. Here we show that patients with stroke and myocardial ischemia (MI) had strongly reduced IgA blood levels. This was phenocopied in experimental mouse models where decreased plasma and fecal IgA were accompanied by rapid loss of IgA-producing plasma cells in PP and lamina propria. Reduced plasma IgG was detectable in patients and experimental mice 3-10 d after injury. Stroke/MI triggered the release of neutrophil extracellular traps (NETs). Depletion of neutrophils, NET degradation or blockade of NET release inhibited the loss of IgA
cells and circulating IgA in experimental stroke and MI and in patients with stroke. Our results unveil how tissue-injury-triggered systemic NET release disrupts physiological Ig secretion and how this can be inhibited in patients. |
| doi_str_mv | 10.1038/s44161-024-00462-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11358010</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3097854599</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-3bcff9c7f6d144fbac844daea3b8e594e5f8cfa753970b325d1a1497a09cabd73</originalsourceid><addsrcrecordid>eNpVkc-OFCEQxonRuJtxX8CD4eilFQaYbk7GbPyXbOJBPZNqqJ4h0tBCY5yX8JllnN3N7okv1Ff1FfwIecnZG87E8LZIyXe8Y1vZMSZ32254Qi63vWhXSrOnD_QFuSrFjyfToHrRPycXQnOttOCX5O-3NaefSCE6Oh-Thew8BOrjBNmuPsUmXbVII9bmXA4-UPyzZrAYQg2QadMLzRgQClLnS67L6uOehuO8HJJ3NOU9RFrWXO1a8znKz3ONaR_SWINvRbQZT2kvyLMJQsGr23NDfnz88P36c3fz9dOX6_c3nZVMrJ0Y7TRp2087x6WcRrCDlA4QxDig0hLVNNgJeiV0z0axVY4Dl7oHpi2Mrhcb8u48d6njjM5ibM8IZsl-hnw0Cbx5XIn-YPbpt-FcqIE1Ahvy-nZCTr8qltXMvpw-BSKmWoxguh-UVFo36_ZstTmVknG6z-HMnGCaM0zTYJr_MM3Qml493PC-5Q6d-AcOM6G6</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3097854599</pqid></control><display><type>article</type><title>Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Tuz, Ali A ; Ghosh, Susmita ; Karsch, Laura ; Ttoouli, Dimitris ; Sata, Sai P ; Ulusoy, Özgür ; Kraus, Andreas ; Hoerenbaum, Nils ; Wolf, Jan-Niklas ; Lohmann, Sabrina ; Zwirnlein, Franziska ; Kaygusuz, Viola ; Lakovic, Vivian ; Tummes, Hannah-Lea ; Beer, Alexander ; Gallert, Markus ; Thiebes, Stephanie ; Qefalia, Altea ; Cibir, Zülal ; Antler, Medina ; Korste, Sebastian ; Haj Yehia, Elias ; Michel, Lars ; Rassaf, Tienush ; Kaltwasser, Britta ; Abdelrahman, Hossam ; Mohamud Yusuf, Ayan ; Wang, Chen ; Yin, Dongpei ; Haeusler, Lars ; Lueong, Smiths ; Richter, Mathis ; Engel, Daniel R ; Stenzel, Martin ; Soehnlein, Oliver ; Frank, Benedikt ; Solo-Nomenjanahary, Mialitiana ; Ho-Tin-Noé, Benoît ; Siveke, Jens T ; Totzeck, Matthias ; Hoffmann, Daniel ; Grüneboom, Anika ; Hagemann, Nina ; Hasenberg, Anja ; Desilles, Jean-Philippe ; Mazighi, Mikael ; Sickmann, Albert ; Chen, Jianxu ; Hermann, Dirk M ; Gunzer, Matthias ; Singh, Vikramjeet</creator><creatorcontrib>Tuz, Ali A ; Ghosh, Susmita ; Karsch, Laura ; Ttoouli, Dimitris ; Sata, Sai P ; Ulusoy, Özgür ; Kraus, Andreas ; Hoerenbaum, Nils ; Wolf, Jan-Niklas ; Lohmann, Sabrina ; Zwirnlein, Franziska ; Kaygusuz, Viola ; Lakovic, Vivian ; Tummes, Hannah-Lea ; Beer, Alexander ; Gallert, Markus ; Thiebes, Stephanie ; Qefalia, Altea ; Cibir, Zülal ; Antler, Medina ; Korste, Sebastian ; Haj Yehia, Elias ; Michel, Lars ; Rassaf, Tienush ; Kaltwasser, Britta ; Abdelrahman, Hossam ; Mohamud Yusuf, Ayan ; Wang, Chen ; Yin, Dongpei ; Haeusler, Lars ; Lueong, Smiths ; Richter, Mathis ; Engel, Daniel R ; Stenzel, Martin ; Soehnlein, Oliver ; Frank, Benedikt ; Solo-Nomenjanahary, Mialitiana ; Ho-Tin-Noé, Benoît ; Siveke, Jens T ; Totzeck, Matthias ; Hoffmann, Daniel ; Grüneboom, Anika ; Hagemann, Nina ; Hasenberg, Anja ; Desilles, Jean-Philippe ; Mazighi, Mikael ; Sickmann, Albert ; Chen, Jianxu ; Hermann, Dirk M ; Gunzer, Matthias ; Singh, Vikramjeet</creatorcontrib><description>Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in cardiovascular diseases. Among immunoglobulins (Ig), IgA, the most abundant mucosal antibody, is produced by plasma B cells in intestinal Peyer's patches (PP) and lamina propria. Here we show that patients with stroke and myocardial ischemia (MI) had strongly reduced IgA blood levels. This was phenocopied in experimental mouse models where decreased plasma and fecal IgA were accompanied by rapid loss of IgA-producing plasma cells in PP and lamina propria. Reduced plasma IgG was detectable in patients and experimental mice 3-10 d after injury. Stroke/MI triggered the release of neutrophil extracellular traps (NETs). Depletion of neutrophils, NET degradation or blockade of NET release inhibited the loss of IgA
cells and circulating IgA in experimental stroke and MI and in patients with stroke. Our results unveil how tissue-injury-triggered systemic NET release disrupts physiological Ig secretion and how this can be inhibited in patients.</description><identifier>ISSN: 2731-0590</identifier><identifier>EISSN: 2731-0590</identifier><identifier>DOI: 10.1038/s44161-024-00462-8</identifier><identifier>PMID: 39195931</identifier><language>eng</language><publisher>England: Nature Publishing Group UK</publisher><subject>Aged ; Animals ; Case-Control Studies ; Disease Models, Animal ; Extracellular Traps - immunology ; Extracellular Traps - metabolism ; Female ; Humans ; Immunity, Humoral ; Immunoglobulin A - blood ; Immunoglobulin A - immunology ; Immunoglobulin A - metabolism ; Immunoglobulin G - immunology ; Immunoglobulin G - metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Myocardial Infarction - immunology ; Myocardial Infarction - metabolism ; Myocardial Infarction - pathology ; Neutrophils - immunology ; Neutrophils - metabolism ; Peyer's Patches - immunology ; Peyer's Patches - metabolism ; Peyer's Patches - pathology ; Plasma Cells - immunology ; Plasma Cells - metabolism ; Stroke - immunology ; Stroke - metabolism ; Stroke - pathology</subject><ispartof>Nature Cardiovascular Research, 2024-05, Vol.3 (5), p.525-540</ispartof><rights>2024. The Author(s).</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-3bcff9c7f6d144fbac844daea3b8e594e5f8cfa753970b325d1a1497a09cabd73</citedby><cites>FETCH-LOGICAL-c403t-3bcff9c7f6d144fbac844daea3b8e594e5f8cfa753970b325d1a1497a09cabd73</cites><orcidid>0000-0003-2973-7869 ; 0000-0002-3110-6137 ; 0000-0002-7928-5613 ; 0000-0002-7361-8317 ; 0000-0002-1378-2529 ; 0000-0003-0198-3152 ; 0000-0002-8500-1357 ; 0000-0001-5320-3889 ; 0000-0002-7854-0694 ; 0000-0002-7428-1760 ; 0000-0002-5534-6055 ; 0000-0001-7301-353X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39195931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuz, Ali A</creatorcontrib><creatorcontrib>Ghosh, Susmita</creatorcontrib><creatorcontrib>Karsch, Laura</creatorcontrib><creatorcontrib>Ttoouli, Dimitris</creatorcontrib><creatorcontrib>Sata, Sai P</creatorcontrib><creatorcontrib>Ulusoy, Özgür</creatorcontrib><creatorcontrib>Kraus, Andreas</creatorcontrib><creatorcontrib>Hoerenbaum, Nils</creatorcontrib><creatorcontrib>Wolf, Jan-Niklas</creatorcontrib><creatorcontrib>Lohmann, Sabrina</creatorcontrib><creatorcontrib>Zwirnlein, Franziska</creatorcontrib><creatorcontrib>Kaygusuz, Viola</creatorcontrib><creatorcontrib>Lakovic, Vivian</creatorcontrib><creatorcontrib>Tummes, Hannah-Lea</creatorcontrib><creatorcontrib>Beer, Alexander</creatorcontrib><creatorcontrib>Gallert, Markus</creatorcontrib><creatorcontrib>Thiebes, Stephanie</creatorcontrib><creatorcontrib>Qefalia, Altea</creatorcontrib><creatorcontrib>Cibir, Zülal</creatorcontrib><creatorcontrib>Antler, Medina</creatorcontrib><creatorcontrib>Korste, Sebastian</creatorcontrib><creatorcontrib>Haj Yehia, Elias</creatorcontrib><creatorcontrib>Michel, Lars</creatorcontrib><creatorcontrib>Rassaf, Tienush</creatorcontrib><creatorcontrib>Kaltwasser, Britta</creatorcontrib><creatorcontrib>Abdelrahman, Hossam</creatorcontrib><creatorcontrib>Mohamud Yusuf, Ayan</creatorcontrib><creatorcontrib>Wang, Chen</creatorcontrib><creatorcontrib>Yin, Dongpei</creatorcontrib><creatorcontrib>Haeusler, Lars</creatorcontrib><creatorcontrib>Lueong, Smiths</creatorcontrib><creatorcontrib>Richter, Mathis</creatorcontrib><creatorcontrib>Engel, Daniel R</creatorcontrib><creatorcontrib>Stenzel, Martin</creatorcontrib><creatorcontrib>Soehnlein, Oliver</creatorcontrib><creatorcontrib>Frank, Benedikt</creatorcontrib><creatorcontrib>Solo-Nomenjanahary, Mialitiana</creatorcontrib><creatorcontrib>Ho-Tin-Noé, Benoît</creatorcontrib><creatorcontrib>Siveke, Jens T</creatorcontrib><creatorcontrib>Totzeck, Matthias</creatorcontrib><creatorcontrib>Hoffmann, Daniel</creatorcontrib><creatorcontrib>Grüneboom, Anika</creatorcontrib><creatorcontrib>Hagemann, Nina</creatorcontrib><creatorcontrib>Hasenberg, Anja</creatorcontrib><creatorcontrib>Desilles, Jean-Philippe</creatorcontrib><creatorcontrib>Mazighi, Mikael</creatorcontrib><creatorcontrib>Sickmann, Albert</creatorcontrib><creatorcontrib>Chen, Jianxu</creatorcontrib><creatorcontrib>Hermann, Dirk M</creatorcontrib><creatorcontrib>Gunzer, Matthias</creatorcontrib><creatorcontrib>Singh, Vikramjeet</creatorcontrib><title>Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion</title><title>Nature Cardiovascular Research</title><addtitle>Nat Cardiovasc Res</addtitle><description>Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in cardiovascular diseases. Among immunoglobulins (Ig), IgA, the most abundant mucosal antibody, is produced by plasma B cells in intestinal Peyer's patches (PP) and lamina propria. Here we show that patients with stroke and myocardial ischemia (MI) had strongly reduced IgA blood levels. This was phenocopied in experimental mouse models where decreased plasma and fecal IgA were accompanied by rapid loss of IgA-producing plasma cells in PP and lamina propria. Reduced plasma IgG was detectable in patients and experimental mice 3-10 d after injury. Stroke/MI triggered the release of neutrophil extracellular traps (NETs). Depletion of neutrophils, NET degradation or blockade of NET release inhibited the loss of IgA
cells and circulating IgA in experimental stroke and MI and in patients with stroke. Our results unveil how tissue-injury-triggered systemic NET release disrupts physiological Ig secretion and how this can be inhibited in patients.</description><subject>Aged</subject><subject>Animals</subject><subject>Case-Control Studies</subject><subject>Disease Models, Animal</subject><subject>Extracellular Traps - immunology</subject><subject>Extracellular Traps - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunity, Humoral</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin A - immunology</subject><subject>Immunoglobulin A - metabolism</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin G - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - immunology</subject><subject>Myocardial Infarction - metabolism</subject><subject>Myocardial Infarction - pathology</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - metabolism</subject><subject>Peyer's Patches - immunology</subject><subject>Peyer's Patches - metabolism</subject><subject>Peyer's Patches - pathology</subject><subject>Plasma Cells - immunology</subject><subject>Plasma Cells - metabolism</subject><subject>Stroke - immunology</subject><subject>Stroke - metabolism</subject><subject>Stroke - pathology</subject><issn>2731-0590</issn><issn>2731-0590</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc-OFCEQxonRuJtxX8CD4eilFQaYbk7GbPyXbOJBPZNqqJ4h0tBCY5yX8JllnN3N7okv1Ff1FfwIecnZG87E8LZIyXe8Y1vZMSZ32254Qi63vWhXSrOnD_QFuSrFjyfToHrRPycXQnOttOCX5O-3NaefSCE6Oh-Thew8BOrjBNmuPsUmXbVII9bmXA4-UPyzZrAYQg2QadMLzRgQClLnS67L6uOehuO8HJJ3NOU9RFrWXO1a8znKz3ONaR_SWINvRbQZT2kvyLMJQsGr23NDfnz88P36c3fz9dOX6_c3nZVMrJ0Y7TRp2087x6WcRrCDlA4QxDig0hLVNNgJeiV0z0axVY4Dl7oHpi2Mrhcb8u48d6njjM5ibM8IZsl-hnw0Cbx5XIn-YPbpt-FcqIE1Ahvy-nZCTr8qltXMvpw-BSKmWoxguh-UVFo36_ZstTmVknG6z-HMnGCaM0zTYJr_MM3Qml493PC-5Q6d-AcOM6G6</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Tuz, Ali A</creator><creator>Ghosh, Susmita</creator><creator>Karsch, Laura</creator><creator>Ttoouli, Dimitris</creator><creator>Sata, Sai P</creator><creator>Ulusoy, Özgür</creator><creator>Kraus, Andreas</creator><creator>Hoerenbaum, Nils</creator><creator>Wolf, Jan-Niklas</creator><creator>Lohmann, Sabrina</creator><creator>Zwirnlein, Franziska</creator><creator>Kaygusuz, Viola</creator><creator>Lakovic, Vivian</creator><creator>Tummes, Hannah-Lea</creator><creator>Beer, Alexander</creator><creator>Gallert, Markus</creator><creator>Thiebes, Stephanie</creator><creator>Qefalia, Altea</creator><creator>Cibir, Zülal</creator><creator>Antler, Medina</creator><creator>Korste, Sebastian</creator><creator>Haj Yehia, Elias</creator><creator>Michel, Lars</creator><creator>Rassaf, Tienush</creator><creator>Kaltwasser, Britta</creator><creator>Abdelrahman, Hossam</creator><creator>Mohamud Yusuf, Ayan</creator><creator>Wang, Chen</creator><creator>Yin, Dongpei</creator><creator>Haeusler, Lars</creator><creator>Lueong, Smiths</creator><creator>Richter, Mathis</creator><creator>Engel, Daniel R</creator><creator>Stenzel, Martin</creator><creator>Soehnlein, Oliver</creator><creator>Frank, Benedikt</creator><creator>Solo-Nomenjanahary, Mialitiana</creator><creator>Ho-Tin-Noé, Benoît</creator><creator>Siveke, Jens T</creator><creator>Totzeck, Matthias</creator><creator>Hoffmann, Daniel</creator><creator>Grüneboom, Anika</creator><creator>Hagemann, Nina</creator><creator>Hasenberg, Anja</creator><creator>Desilles, Jean-Philippe</creator><creator>Mazighi, Mikael</creator><creator>Sickmann, Albert</creator><creator>Chen, Jianxu</creator><creator>Hermann, Dirk M</creator><creator>Gunzer, Matthias</creator><creator>Singh, Vikramjeet</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2973-7869</orcidid><orcidid>https://orcid.org/0000-0002-3110-6137</orcidid><orcidid>https://orcid.org/0000-0002-7928-5613</orcidid><orcidid>https://orcid.org/0000-0002-7361-8317</orcidid><orcidid>https://orcid.org/0000-0002-1378-2529</orcidid><orcidid>https://orcid.org/0000-0003-0198-3152</orcidid><orcidid>https://orcid.org/0000-0002-8500-1357</orcidid><orcidid>https://orcid.org/0000-0001-5320-3889</orcidid><orcidid>https://orcid.org/0000-0002-7854-0694</orcidid><orcidid>https://orcid.org/0000-0002-7428-1760</orcidid><orcidid>https://orcid.org/0000-0002-5534-6055</orcidid><orcidid>https://orcid.org/0000-0001-7301-353X</orcidid></search><sort><creationdate>20240501</creationdate><title>Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion</title><author>Tuz, Ali A ; Ghosh, Susmita ; Karsch, Laura ; Ttoouli, Dimitris ; Sata, Sai P ; Ulusoy, Özgür ; Kraus, Andreas ; Hoerenbaum, Nils ; Wolf, Jan-Niklas ; Lohmann, Sabrina ; Zwirnlein, Franziska ; Kaygusuz, Viola ; Lakovic, Vivian ; Tummes, Hannah-Lea ; Beer, Alexander ; Gallert, Markus ; Thiebes, Stephanie ; Qefalia, Altea ; Cibir, Zülal ; Antler, Medina ; Korste, Sebastian ; Haj Yehia, Elias ; Michel, Lars ; Rassaf, Tienush ; Kaltwasser, Britta ; Abdelrahman, Hossam ; Mohamud Yusuf, Ayan ; Wang, Chen ; Yin, Dongpei ; Haeusler, Lars ; Lueong, Smiths ; Richter, Mathis ; Engel, Daniel R ; Stenzel, Martin ; Soehnlein, Oliver ; Frank, Benedikt ; Solo-Nomenjanahary, Mialitiana ; Ho-Tin-Noé, Benoît ; Siveke, Jens T ; Totzeck, Matthias ; Hoffmann, Daniel ; Grüneboom, Anika ; Hagemann, Nina ; Hasenberg, Anja ; Desilles, Jean-Philippe ; Mazighi, Mikael ; Sickmann, Albert ; Chen, Jianxu ; Hermann, Dirk M ; Gunzer, Matthias ; Singh, Vikramjeet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-3bcff9c7f6d144fbac844daea3b8e594e5f8cfa753970b325d1a1497a09cabd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Animals</topic><topic>Case-Control Studies</topic><topic>Disease Models, Animal</topic><topic>Extracellular Traps - immunology</topic><topic>Extracellular Traps - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunity, Humoral</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin A - immunology</topic><topic>Immunoglobulin A - metabolism</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin G - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - immunology</topic><topic>Myocardial Infarction - metabolism</topic><topic>Myocardial Infarction - pathology</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - metabolism</topic><topic>Peyer's Patches - immunology</topic><topic>Peyer's Patches - metabolism</topic><topic>Peyer's Patches - pathology</topic><topic>Plasma Cells - immunology</topic><topic>Plasma Cells - metabolism</topic><topic>Stroke - immunology</topic><topic>Stroke - metabolism</topic><topic>Stroke - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuz, Ali A</creatorcontrib><creatorcontrib>Ghosh, Susmita</creatorcontrib><creatorcontrib>Karsch, Laura</creatorcontrib><creatorcontrib>Ttoouli, Dimitris</creatorcontrib><creatorcontrib>Sata, Sai P</creatorcontrib><creatorcontrib>Ulusoy, Özgür</creatorcontrib><creatorcontrib>Kraus, Andreas</creatorcontrib><creatorcontrib>Hoerenbaum, Nils</creatorcontrib><creatorcontrib>Wolf, Jan-Niklas</creatorcontrib><creatorcontrib>Lohmann, Sabrina</creatorcontrib><creatorcontrib>Zwirnlein, Franziska</creatorcontrib><creatorcontrib>Kaygusuz, Viola</creatorcontrib><creatorcontrib>Lakovic, Vivian</creatorcontrib><creatorcontrib>Tummes, Hannah-Lea</creatorcontrib><creatorcontrib>Beer, Alexander</creatorcontrib><creatorcontrib>Gallert, Markus</creatorcontrib><creatorcontrib>Thiebes, Stephanie</creatorcontrib><creatorcontrib>Qefalia, Altea</creatorcontrib><creatorcontrib>Cibir, Zülal</creatorcontrib><creatorcontrib>Antler, Medina</creatorcontrib><creatorcontrib>Korste, Sebastian</creatorcontrib><creatorcontrib>Haj Yehia, Elias</creatorcontrib><creatorcontrib>Michel, Lars</creatorcontrib><creatorcontrib>Rassaf, Tienush</creatorcontrib><creatorcontrib>Kaltwasser, Britta</creatorcontrib><creatorcontrib>Abdelrahman, Hossam</creatorcontrib><creatorcontrib>Mohamud Yusuf, Ayan</creatorcontrib><creatorcontrib>Wang, Chen</creatorcontrib><creatorcontrib>Yin, Dongpei</creatorcontrib><creatorcontrib>Haeusler, Lars</creatorcontrib><creatorcontrib>Lueong, Smiths</creatorcontrib><creatorcontrib>Richter, Mathis</creatorcontrib><creatorcontrib>Engel, Daniel R</creatorcontrib><creatorcontrib>Stenzel, Martin</creatorcontrib><creatorcontrib>Soehnlein, Oliver</creatorcontrib><creatorcontrib>Frank, Benedikt</creatorcontrib><creatorcontrib>Solo-Nomenjanahary, Mialitiana</creatorcontrib><creatorcontrib>Ho-Tin-Noé, Benoît</creatorcontrib><creatorcontrib>Siveke, Jens T</creatorcontrib><creatorcontrib>Totzeck, Matthias</creatorcontrib><creatorcontrib>Hoffmann, Daniel</creatorcontrib><creatorcontrib>Grüneboom, Anika</creatorcontrib><creatorcontrib>Hagemann, Nina</creatorcontrib><creatorcontrib>Hasenberg, Anja</creatorcontrib><creatorcontrib>Desilles, Jean-Philippe</creatorcontrib><creatorcontrib>Mazighi, Mikael</creatorcontrib><creatorcontrib>Sickmann, Albert</creatorcontrib><creatorcontrib>Chen, Jianxu</creatorcontrib><creatorcontrib>Hermann, Dirk M</creatorcontrib><creatorcontrib>Gunzer, Matthias</creatorcontrib><creatorcontrib>Singh, Vikramjeet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature Cardiovascular Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuz, Ali A</au><au>Ghosh, Susmita</au><au>Karsch, Laura</au><au>Ttoouli, Dimitris</au><au>Sata, Sai P</au><au>Ulusoy, Özgür</au><au>Kraus, Andreas</au><au>Hoerenbaum, Nils</au><au>Wolf, Jan-Niklas</au><au>Lohmann, Sabrina</au><au>Zwirnlein, Franziska</au><au>Kaygusuz, Viola</au><au>Lakovic, Vivian</au><au>Tummes, Hannah-Lea</au><au>Beer, Alexander</au><au>Gallert, Markus</au><au>Thiebes, Stephanie</au><au>Qefalia, Altea</au><au>Cibir, Zülal</au><au>Antler, Medina</au><au>Korste, Sebastian</au><au>Haj Yehia, Elias</au><au>Michel, Lars</au><au>Rassaf, Tienush</au><au>Kaltwasser, Britta</au><au>Abdelrahman, Hossam</au><au>Mohamud Yusuf, Ayan</au><au>Wang, Chen</au><au>Yin, Dongpei</au><au>Haeusler, Lars</au><au>Lueong, Smiths</au><au>Richter, Mathis</au><au>Engel, Daniel R</au><au>Stenzel, Martin</au><au>Soehnlein, Oliver</au><au>Frank, Benedikt</au><au>Solo-Nomenjanahary, Mialitiana</au><au>Ho-Tin-Noé, Benoît</au><au>Siveke, Jens T</au><au>Totzeck, Matthias</au><au>Hoffmann, Daniel</au><au>Grüneboom, Anika</au><au>Hagemann, Nina</au><au>Hasenberg, Anja</au><au>Desilles, Jean-Philippe</au><au>Mazighi, Mikael</au><au>Sickmann, Albert</au><au>Chen, Jianxu</au><au>Hermann, Dirk M</au><au>Gunzer, Matthias</au><au>Singh, Vikramjeet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion</atitle><jtitle>Nature Cardiovascular Research</jtitle><addtitle>Nat Cardiovasc Res</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>3</volume><issue>5</issue><spage>525</spage><epage>540</epage><pages>525-540</pages><issn>2731-0590</issn><eissn>2731-0590</eissn><abstract>Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in cardiovascular diseases. Among immunoglobulins (Ig), IgA, the most abundant mucosal antibody, is produced by plasma B cells in intestinal Peyer's patches (PP) and lamina propria. Here we show that patients with stroke and myocardial ischemia (MI) had strongly reduced IgA blood levels. This was phenocopied in experimental mouse models where decreased plasma and fecal IgA were accompanied by rapid loss of IgA-producing plasma cells in PP and lamina propria. Reduced plasma IgG was detectable in patients and experimental mice 3-10 d after injury. Stroke/MI triggered the release of neutrophil extracellular traps (NETs). Depletion of neutrophils, NET degradation or blockade of NET release inhibited the loss of IgA
cells and circulating IgA in experimental stroke and MI and in patients with stroke. Our results unveil how tissue-injury-triggered systemic NET release disrupts physiological Ig secretion and how this can be inhibited in patients.</abstract><cop>England</cop><pub>Nature Publishing Group UK</pub><pmid>39195931</pmid><doi>10.1038/s44161-024-00462-8</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-2973-7869</orcidid><orcidid>https://orcid.org/0000-0002-3110-6137</orcidid><orcidid>https://orcid.org/0000-0002-7928-5613</orcidid><orcidid>https://orcid.org/0000-0002-7361-8317</orcidid><orcidid>https://orcid.org/0000-0002-1378-2529</orcidid><orcidid>https://orcid.org/0000-0003-0198-3152</orcidid><orcidid>https://orcid.org/0000-0002-8500-1357</orcidid><orcidid>https://orcid.org/0000-0001-5320-3889</orcidid><orcidid>https://orcid.org/0000-0002-7854-0694</orcidid><orcidid>https://orcid.org/0000-0002-7428-1760</orcidid><orcidid>https://orcid.org/0000-0002-5534-6055</orcidid><orcidid>https://orcid.org/0000-0001-7301-353X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2731-0590 |
| ispartof | Nature Cardiovascular Research, 2024-05, Vol.3 (5), p.525-540 |
| issn | 2731-0590 2731-0590 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11358010 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Animals Case-Control Studies Disease Models, Animal Extracellular Traps - immunology Extracellular Traps - metabolism Female Humans Immunity, Humoral Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulin A - metabolism Immunoglobulin G - immunology Immunoglobulin G - metabolism Male Mice Mice, Inbred C57BL Middle Aged Myocardial Infarction - immunology Myocardial Infarction - metabolism Myocardial Infarction - pathology Neutrophils - immunology Neutrophils - metabolism Peyer's Patches - immunology Peyer's Patches - metabolism Peyer's Patches - pathology Plasma Cells - immunology Plasma Cells - metabolism Stroke - immunology Stroke - metabolism Stroke - pathology |
| title | Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T16%3A36%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stroke%20and%20myocardial%20infarction%20induce%20neutrophil%20extracellular%20trap%20release%20disrupting%20lymphoid%20organ%20structure%20and%20immunoglobulin%20secretion&rft.jtitle=Nature%20Cardiovascular%20Research&rft.au=Tuz,%20Ali%20A&rft.date=2024-05-01&rft.volume=3&rft.issue=5&rft.spage=525&rft.epage=540&rft.pages=525-540&rft.issn=2731-0590&rft.eissn=2731-0590&rft_id=info:doi/10.1038/s44161-024-00462-8&rft_dat=%3Cproquest_pubme%3E3097854599%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3097854599&rft_id=info:pmid/39195931&rfr_iscdi=true |