Cleavage of folates during ethanol metabolism. Role of acetaldehyde/xanthine oxidase-generated superoxide

Although folate deficiency and increased requirements for folate are observed in most alcoholics, the possibility that acetaldehyde generated from ethanol metabolism may increase folate catabolism has not been previously demonstrated. Folate cleavage was studied in vitro during the metabolism of ace...

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Veröffentlicht in:	Biochemical journal 1989, Vol.257 (1), p.277-280
Hauptverfasser:	Shaw, S, Jayatilleke, E, Herbert, V, Colman, N
Format:	Artikel
Sprache:	eng
Schlagworte:	acetaldehyde Acetaldehyde - metabolism catalytic activity cleavage ethanol Ethanol - metabolism Ferritins - metabolism folic acid Folic Acid - metabolism Leucovorin - metabolism metabolism Superoxides - metabolism Tetrahydrofolates - metabolism xanthine oxidase Xanthine Oxidase - metabolism
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