High Prevalence of ESBL Genes in Commensal Escherichia coli of the Urinary Tract: Implications for Antibiotic Stewardship among Residents of Ghanaian Elderly Nursing Care Homes
The emergence and spread of extended-spectrum β-lactamase (ESBL)-producing ( ) pose significant challenges to the treatment and control of urinary tract infections, particularly among vulnerable populations, such as the elderly living in nursing care homes. In this study, we investigated the occurre...
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| Veröffentlicht in: | Genes 2024-07, Vol.15 (8), p.985 |
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| creator | Armah, Emmanuel Osae-Nyarko, Lawrencia Idun, Bright Ahiabu, Mawutor Kwame Agyapong, Isaac Kwarteng, Freda Boampong Oppong, Mercy Mohammed, Naael Kotey, Fleischer C N Osei-Atweneboana, Mike Yaw Dayie, Nicholas T K D |
| description | The emergence and spread of extended-spectrum β-lactamase (ESBL)-producing
(
) pose significant challenges to the treatment and control of urinary tract infections, particularly among vulnerable populations, such as the elderly living in nursing care homes. In this study, we investigated the occurrence of ESBL genes in commensal
isolated from urine samples of 118 elderly individuals residing in Ghanaian nursing care homes. A total of 195 ESBL genes were detected among 41
isolated from the study participants. All the isolates harboured at least one ESBL gene, and the majority of them (70.1%) carried at least four ESBL genes. Among the ESBL genes detected,
was the predominant (14.1%). In antimicrobial susceptibility testing, 65.9% of the isolates showed resistance to cefepime, a fourth-generation cephalosporin, while 56.1% showed resistance to cefotaxime, a third-generation cephalosporin. Additionally, 46.3% of the isolates were multidrug-resistant, indicating resistance to antibiotics from multiple classes. In summary, we observed relatively high rates of resistance to antibiotics as well as alarming rates of ESBL genes in the isolated pathogens. These findings emphasise the urgent need for antimicrobial stewardship and infection control programmes to mitigate the spread of multidrug-resistant pathogens in nursing care homes. |
| doi_str_mv | 10.3390/genes15080985 |
| format | Article |
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(
) pose significant challenges to the treatment and control of urinary tract infections, particularly among vulnerable populations, such as the elderly living in nursing care homes. In this study, we investigated the occurrence of ESBL genes in commensal
isolated from urine samples of 118 elderly individuals residing in Ghanaian nursing care homes. A total of 195 ESBL genes were detected among 41
isolated from the study participants. All the isolates harboured at least one ESBL gene, and the majority of them (70.1%) carried at least four ESBL genes. Among the ESBL genes detected,
was the predominant (14.1%). In antimicrobial susceptibility testing, 65.9% of the isolates showed resistance to cefepime, a fourth-generation cephalosporin, while 56.1% showed resistance to cefotaxime, a third-generation cephalosporin. Additionally, 46.3% of the isolates were multidrug-resistant, indicating resistance to antibiotics from multiple classes. In summary, we observed relatively high rates of resistance to antibiotics as well as alarming rates of ESBL genes in the isolated pathogens. These findings emphasise the urgent need for antimicrobial stewardship and infection control programmes to mitigate the spread of multidrug-resistant pathogens in nursing care homes.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes15080985</identifier><identifier>PMID: 39202346</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Aged ; Aged patients ; Aged, 80 and over ; Annealing ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antibiotic resistance ; Antibiotics ; Antimicrobial agents ; Antimicrobial Stewardship ; Bacteria ; beta-Lactamases - genetics ; Care and treatment ; Cefepime ; Cefotaxime ; Control ; Diagnosis ; disease control ; Dosage and administration ; Drug Resistance, Multiple, Bacterial - genetics ; Drug therapy ; E coli ; elderly ; Escherichia coli ; Escherichia coli - drug effects ; Escherichia coli - genetics ; Escherichia coli - isolation & purification ; Escherichia coli Infections - drug therapy ; Escherichia coli Infections - epidemiology ; Escherichia coli Infections - microbiology ; Escherichia coli Proteins - genetics ; Female ; Genes ; Ghana - epidemiology ; Humans ; Identification and classification ; Male ; Microbial Sensitivity Tests ; Multidrug resistance ; multiple drug resistance ; Nursing ; Nursing care ; Nursing Homes ; Older people ; Pathogens ; Phylogenetics ; Population studies ; Prevalence ; Surveillance ; Urinary tract ; Urinary Tract - microbiology ; Urinary tract infections ; Urinary Tract Infections - drug therapy ; Urinary Tract Infections - microbiology ; Urine ; Urogenital system ; β Lactamase</subject><ispartof>Genes, 2024-07, Vol.15 (8), p.985</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c402t-985357eb0755e504a8f20f2f5d1bbc5c7f7cfdf3cb262a4b51d1d764bb85d7b23</cites><orcidid>0009-0002-8493-3272 ; 0000-0003-4491-6902 ; 0000-0001-9364-9690 ; 0000-0002-9608-3554 ; 0000-0003-0286-3638</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354122/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11354122/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39202346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Armah, Emmanuel</creatorcontrib><creatorcontrib>Osae-Nyarko, Lawrencia</creatorcontrib><creatorcontrib>Idun, Bright</creatorcontrib><creatorcontrib>Ahiabu, Mawutor Kwame</creatorcontrib><creatorcontrib>Agyapong, Isaac</creatorcontrib><creatorcontrib>Kwarteng, Freda Boampong</creatorcontrib><creatorcontrib>Oppong, Mercy</creatorcontrib><creatorcontrib>Mohammed, Naael</creatorcontrib><creatorcontrib>Kotey, Fleischer C N</creatorcontrib><creatorcontrib>Osei-Atweneboana, Mike Yaw</creatorcontrib><creatorcontrib>Dayie, Nicholas T K D</creatorcontrib><title>High Prevalence of ESBL Genes in Commensal Escherichia coli of the Urinary Tract: Implications for Antibiotic Stewardship among Residents of Ghanaian Elderly Nursing Care Homes</title><title>Genes</title><addtitle>Genes (Basel)</addtitle><description>The emergence and spread of extended-spectrum β-lactamase (ESBL)-producing
(
) pose significant challenges to the treatment and control of urinary tract infections, particularly among vulnerable populations, such as the elderly living in nursing care homes. In this study, we investigated the occurrence of ESBL genes in commensal
isolated from urine samples of 118 elderly individuals residing in Ghanaian nursing care homes. A total of 195 ESBL genes were detected among 41
isolated from the study participants. All the isolates harboured at least one ESBL gene, and the majority of them (70.1%) carried at least four ESBL genes. Among the ESBL genes detected,
was the predominant (14.1%). In antimicrobial susceptibility testing, 65.9% of the isolates showed resistance to cefepime, a fourth-generation cephalosporin, while 56.1% showed resistance to cefotaxime, a third-generation cephalosporin. Additionally, 46.3% of the isolates were multidrug-resistant, indicating resistance to antibiotics from multiple classes. In summary, we observed relatively high rates of resistance to antibiotics as well as alarming rates of ESBL genes in the isolated pathogens. These findings emphasise the urgent need for antimicrobial stewardship and infection control programmes to mitigate the spread of multidrug-resistant pathogens in nursing care homes.</description><subject>Aged</subject><subject>Aged patients</subject><subject>Aged, 80 and over</subject><subject>Annealing</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial Stewardship</subject><subject>Bacteria</subject><subject>beta-Lactamases - genetics</subject><subject>Care and treatment</subject><subject>Cefepime</subject><subject>Cefotaxime</subject><subject>Control</subject><subject>Diagnosis</subject><subject>disease control</subject><subject>Dosage and administration</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Drug therapy</subject><subject>E coli</subject><subject>elderly</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli - isolation & purification</subject><subject>Escherichia coli Infections - drug therapy</subject><subject>Escherichia coli Infections - epidemiology</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Escherichia coli Proteins - genetics</subject><subject>Female</subject><subject>Genes</subject><subject>Ghana - epidemiology</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Multidrug resistance</subject><subject>multiple drug resistance</subject><subject>Nursing</subject><subject>Nursing care</subject><subject>Nursing Homes</subject><subject>Older people</subject><subject>Pathogens</subject><subject>Phylogenetics</subject><subject>Population studies</subject><subject>Prevalence</subject><subject>Surveillance</subject><subject>Urinary tract</subject><subject>Urinary Tract - microbiology</subject><subject>Urinary tract infections</subject><subject>Urinary Tract Infections - drug therapy</subject><subject>Urinary Tract Infections - microbiology</subject><subject>Urine</subject><subject>Urogenital system</subject><subject>β Lactamase</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkk1vEzEQhlcIRKvQI1dkiQuXFH-ss7tcUBqFpFIEiLZny-sdZ6fatYO9Keq_4ifipaFqEBL2wZb9zKuZdybLXjN6LkRF32_BQWSSlrQq5bPslNNCTPOcy-dP7ifZWYy3NK2cckrly-xEVJxykc9Os59r3Lbka4A73YEzQLwly6uLDVmN0gQdWfi-Bxd1R5bRtBDQtKiJ8R2O7NACuQnodLgn10Gb4QO57HcdGj2gd5FYH8jcDVijH9CQqwF-6NDEFndE995tyTeI2IAb4qi2arXTqB1Zdg2E7p583oeIiVroAGTte4ivshdWdxHODucku_m0vF6sp5svq8vFfDM1qcphmvwQsoCaFlKCpLkuLaeWW9mwujbSFLYwtrHC1HzGdV5L1rCmmOV1XcqmqLmYZB8fdHf7uofGpBSD7tQuYJ9qVV6jOv5x2Kqtv1OMCZkzPiq8OygE_30PcVA9RgNdpx34fVSCSVGUqUHV_1FaVUUlSs4S-vYv9Nbvg0tWjFRR0TL_LXigtqmtCp31KUcziqp5SYucVWUyaJKd_4NKu4EejXdgMb0fBUwfAkzwMQawj34wqsaJVEcTmfg3T018pP_Mn_gFekfdVw</recordid><startdate>20240726</startdate><enddate>20240726</enddate><creator>Armah, Emmanuel</creator><creator>Osae-Nyarko, Lawrencia</creator><creator>Idun, Bright</creator><creator>Ahiabu, Mawutor Kwame</creator><creator>Agyapong, Isaac</creator><creator>Kwarteng, Freda Boampong</creator><creator>Oppong, Mercy</creator><creator>Mohammed, Naael</creator><creator>Kotey, Fleischer C N</creator><creator>Osei-Atweneboana, Mike Yaw</creator><creator>Dayie, Nicholas T K D</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0002-8493-3272</orcidid><orcidid>https://orcid.org/0000-0003-4491-6902</orcidid><orcidid>https://orcid.org/0000-0001-9364-9690</orcidid><orcidid>https://orcid.org/0000-0002-9608-3554</orcidid><orcidid>https://orcid.org/0000-0003-0286-3638</orcidid></search><sort><creationdate>20240726</creationdate><title>High Prevalence of ESBL Genes in Commensal Escherichia coli of the Urinary Tract: Implications for Antibiotic Stewardship among Residents of Ghanaian Elderly Nursing Care Homes</title><author>Armah, Emmanuel ; Osae-Nyarko, Lawrencia ; Idun, Bright ; Ahiabu, Mawutor Kwame ; Agyapong, Isaac ; Kwarteng, Freda Boampong ; Oppong, Mercy ; Mohammed, Naael ; Kotey, Fleischer C N ; Osei-Atweneboana, Mike Yaw ; Dayie, Nicholas T K D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-985357eb0755e504a8f20f2f5d1bbc5c7f7cfdf3cb262a4b51d1d764bb85d7b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged patients</topic><topic>Aged, 80 and over</topic><topic>Annealing</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Antimicrobial Stewardship</topic><topic>Bacteria</topic><topic>beta-Lactamases - genetics</topic><topic>Care and treatment</topic><topic>Cefepime</topic><topic>Cefotaxime</topic><topic>Control</topic><topic>Diagnosis</topic><topic>disease control</topic><topic>Dosage and administration</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>Drug therapy</topic><topic>E coli</topic><topic>elderly</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli - isolation & purification</topic><topic>Escherichia coli Infections - drug therapy</topic><topic>Escherichia coli Infections - epidemiology</topic><topic>Escherichia coli Infections - microbiology</topic><topic>Escherichia coli Proteins - genetics</topic><topic>Female</topic><topic>Genes</topic><topic>Ghana - epidemiology</topic><topic>Humans</topic><topic>Identification and classification</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Multidrug resistance</topic><topic>multiple drug resistance</topic><topic>Nursing</topic><topic>Nursing care</topic><topic>Nursing Homes</topic><topic>Older people</topic><topic>Pathogens</topic><topic>Phylogenetics</topic><topic>Population studies</topic><topic>Prevalence</topic><topic>Surveillance</topic><topic>Urinary tract</topic><topic>Urinary Tract - microbiology</topic><topic>Urinary tract infections</topic><topic>Urinary Tract Infections - drug therapy</topic><topic>Urinary Tract Infections - microbiology</topic><topic>Urine</topic><topic>Urogenital system</topic><topic>β Lactamase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Armah, Emmanuel</creatorcontrib><creatorcontrib>Osae-Nyarko, Lawrencia</creatorcontrib><creatorcontrib>Idun, Bright</creatorcontrib><creatorcontrib>Ahiabu, Mawutor Kwame</creatorcontrib><creatorcontrib>Agyapong, Isaac</creatorcontrib><creatorcontrib>Kwarteng, Freda Boampong</creatorcontrib><creatorcontrib>Oppong, Mercy</creatorcontrib><creatorcontrib>Mohammed, Naael</creatorcontrib><creatorcontrib>Kotey, Fleischer C N</creatorcontrib><creatorcontrib>Osei-Atweneboana, Mike Yaw</creatorcontrib><creatorcontrib>Dayie, Nicholas T K D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Armah, Emmanuel</au><au>Osae-Nyarko, Lawrencia</au><au>Idun, Bright</au><au>Ahiabu, Mawutor Kwame</au><au>Agyapong, Isaac</au><au>Kwarteng, Freda Boampong</au><au>Oppong, Mercy</au><au>Mohammed, Naael</au><au>Kotey, Fleischer C N</au><au>Osei-Atweneboana, Mike Yaw</au><au>Dayie, Nicholas T K D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Prevalence of ESBL Genes in Commensal Escherichia coli of the Urinary Tract: Implications for Antibiotic Stewardship among Residents of Ghanaian Elderly Nursing Care Homes</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2024-07-26</date><risdate>2024</risdate><volume>15</volume><issue>8</issue><spage>985</spage><pages>985-</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>The emergence and spread of extended-spectrum β-lactamase (ESBL)-producing
(
) pose significant challenges to the treatment and control of urinary tract infections, particularly among vulnerable populations, such as the elderly living in nursing care homes. In this study, we investigated the occurrence of ESBL genes in commensal
isolated from urine samples of 118 elderly individuals residing in Ghanaian nursing care homes. A total of 195 ESBL genes were detected among 41
isolated from the study participants. All the isolates harboured at least one ESBL gene, and the majority of them (70.1%) carried at least four ESBL genes. Among the ESBL genes detected,
was the predominant (14.1%). In antimicrobial susceptibility testing, 65.9% of the isolates showed resistance to cefepime, a fourth-generation cephalosporin, while 56.1% showed resistance to cefotaxime, a third-generation cephalosporin. Additionally, 46.3% of the isolates were multidrug-resistant, indicating resistance to antibiotics from multiple classes. In summary, we observed relatively high rates of resistance to antibiotics as well as alarming rates of ESBL genes in the isolated pathogens. These findings emphasise the urgent need for antimicrobial stewardship and infection control programmes to mitigate the spread of multidrug-resistant pathogens in nursing care homes.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39202346</pmid><doi>10.3390/genes15080985</doi><orcidid>https://orcid.org/0009-0002-8493-3272</orcidid><orcidid>https://orcid.org/0000-0003-4491-6902</orcidid><orcidid>https://orcid.org/0000-0001-9364-9690</orcidid><orcidid>https://orcid.org/0000-0002-9608-3554</orcidid><orcidid>https://orcid.org/0000-0003-0286-3638</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Genes, 2024-07, Vol.15 (8), p.985 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Aged Aged patients Aged, 80 and over Annealing Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotic resistance Antibiotics Antimicrobial agents Antimicrobial Stewardship Bacteria beta-Lactamases - genetics Care and treatment Cefepime Cefotaxime Control Diagnosis disease control Dosage and administration Drug Resistance, Multiple, Bacterial - genetics Drug therapy E coli elderly Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - isolation & purification Escherichia coli Infections - drug therapy Escherichia coli Infections - epidemiology Escherichia coli Infections - microbiology Escherichia coli Proteins - genetics Female Genes Ghana - epidemiology Humans Identification and classification Male Microbial Sensitivity Tests Multidrug resistance multiple drug resistance Nursing Nursing care Nursing Homes Older people Pathogens Phylogenetics Population studies Prevalence Surveillance Urinary tract Urinary Tract - microbiology Urinary tract infections Urinary Tract Infections - drug therapy Urinary Tract Infections - microbiology Urine Urogenital system β Lactamase |
| title | High Prevalence of ESBL Genes in Commensal Escherichia coli of the Urinary Tract: Implications for Antibiotic Stewardship among Residents of Ghanaian Elderly Nursing Care Homes |
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