Genotype-First Approach Identifies an Association between rs28374544/FOG2S657G and Liver Disease through Alterations in mTORC1 Signaling

Metabolic dysfunction-associated Fatty Liver Disease (MAFLD) has emerged as one of the leading cardiometabolic diseases. Friend of GATA2 (FOG2) is a transcriptional co-regulator that has been shown to regulate hepatic lipid metabolism and accumulation. Using meta-analysis from several different biob...

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Veröffentlicht in:	Genes 2024-08, Vol.15 (8), p.1098
Hauptverfasser:	Conlon, Donna M, Kanakala, Siri, Cherlin, Tess, Yi-An, Ko, Vitali, Cecilia, Sharavana Gurunathan, Venkatesh, Rasika, Woerner, Jakob, Guare, Lindsay A, Penn Medicine Biobank, Verma, Anurag, Verma, Shefali S, Guerraty, Marie A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biobanks Cell differentiation Cirrhosis Fatty acids Fatty liver Gene expression Gene frequency Gene set enrichment analysis Genotypes Glycerol Hepatocytes Hepatoma Homeostasis Hypoxia Lipid metabolism Lipids Lipogenesis Liver cancer Liver cirrhosis Liver diseases Medical prognosis Metabolism Molecular modelling Oxidation Oxidative phosphorylation Phenotypes Phosphorylation Pluripotency Proteins Respiration Signal transduction Stem cells
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