Resistance to Anti-HER2 Therapies in Gastrointestinal Malignancies

Human epidermal growth factor 2 (HER2) is a tyrosine kinase receptor that interacts with multiple signaling pathways related to cellular growth and proliferation. Overexpression or amplification of HER2 is linked to various malignancies, and there have been decades of research dedicated to targeting...

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Veröffentlicht in:	Cancers 2024-08, Vol.16 (16), p.2854
Hauptverfasser:	Mo, Christiana, Sterpi, Michelle, Jeon, Hyein, Bteich, Fernand
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Biliary tract Biopsy Breast cancer Cancer therapies Cell growth Chemotherapy Clinical trials Colorectal cancer Cytotoxicity Development and progression Drug resistance Drug therapy Epidermal growth factor ErbB-2 protein FDA approval Gastric cancer Gastrointestinal cancer Intestine Kinases Malignancy Metastasis Monoclonal antibodies Phosphorylation Physiological aspects Protein expression Protein-tyrosine kinase receptors Proteins Review Signal transduction Small intestine Trastuzumab Tumors
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