Effects of Selective and Nonselective Beta Blockers on Bone Mineral Density in Mexican Patients with Breast Cancer
Breast cancer (BCa) is related to chronic stress and can reduce the bone mineral density (BMD) through neurochemicals related to beta-adrenergic receptor (ADRB) 1 and 2. Selective beta blockers (sBBs) and nonselective beta blockers (nsBBs) are used to treat systemic arterial hypertension (SAH) and m...
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| Veröffentlicht in: | Cancers 2024-08, Vol.16 (16), p.2891 |
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| creator | Mejía-Barradas, César Miguel Amador-Martínez, Ana Lara-Padilla, Eleazar Cárdenas-Rodríguez, Noemí Ignacio-Mejía, Iván Martínez-López, Valentín Ibañez-Cervantes, Gabriela Picado-Garcia, Orlando de Jesús Domínguez, Brayan Bandala, Cindy |
| description | Breast cancer (BCa) is related to chronic stress and can reduce the bone mineral density (BMD) through neurochemicals related to beta-adrenergic receptor (ADRB) 1 and 2. Selective beta blockers (sBBs) and nonselective beta blockers (nsBBs) are used to treat systemic arterial hypertension (SAH) and may have osteoprotective effects, as they inhibit ADRBs. To evaluate the effects of sBBs and nsBBs on the BMD of Mexican patients with BCa. A retrospective study was conducted. We included 191 Mexican women with BCa without SAH and with SAH treated with nsBBs, sBBs, and diuretics. BMD was evaluated using a bone density scan (DEX scan). A greater average BMD (
< 0.05) was observed in patients with prior treatment with both nsBBs and sBBs (0.54 ± 0.94 and -0.44 ± 1.22, respectively) compared to patients treated with diuretics or without SAH (-1.73 ± 0.83 and -1.22 ± 0.98, respectively). Regarding the diagnosis of osteoporosis/osteopenia, no cases were observed in patients treated with nsBBs, whereas 5.6% of the patients treated with sBBs presented osteopenia. A total of 23.1% and 10.6% patients managed with diuretics or without treatment presented with osteoporosis and 61.5% and 48% patients managed with loop diuretics and without treatment presented with osteopenia, respectively (
< 0.05). Treatment with nsBBs is a promising option for the prevention and management of osteoporosis/osteopenia in Mexican patients with BCa; however, further prospective studies are needed. |
| doi_str_mv | 10.3390/cancers16162891 |
| format | Article |
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< 0.05) was observed in patients with prior treatment with both nsBBs and sBBs (0.54 ± 0.94 and -0.44 ± 1.22, respectively) compared to patients treated with diuretics or without SAH (-1.73 ± 0.83 and -1.22 ± 0.98, respectively). Regarding the diagnosis of osteoporosis/osteopenia, no cases were observed in patients treated with nsBBs, whereas 5.6% of the patients treated with sBBs presented osteopenia. A total of 23.1% and 10.6% patients managed with diuretics or without treatment presented with osteoporosis and 61.5% and 48% patients managed with loop diuretics and without treatment presented with osteopenia, respectively (
< 0.05). Treatment with nsBBs is a promising option for the prevention and management of osteoporosis/osteopenia in Mexican patients with BCa; however, further prospective studies are needed.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers16162891</identifier><identifier>PMID: 39199661</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adrenergic beta blockers ; Adrenergic receptors ; Beta blockers ; Bone cancer ; Bone density ; Bone mineral density ; Bones ; Breast cancer ; Catecholamines ; Complications and side effects ; Density ; Disease ; Diuretics ; Dosage and administration ; Drug therapy ; Fractures ; Homeostasis ; Hypertension ; Ligands ; Metastasis ; Osteopenia ; Osteoporosis ; Physical activity ; Population studies ; Quality of life ; Receptor density ; Risk factors ; Software ; Standard deviation ; Variance analysis ; Womens health</subject><ispartof>Cancers, 2024-08, Vol.16 (16), p.2891</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-7269-5257 ; 0000-0003-3792-4613 ; 0000-0002-6580-3440 ; 0000-0001-9607-4327</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11352457/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11352457/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39199661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mejía-Barradas, César Miguel</creatorcontrib><creatorcontrib>Amador-Martínez, Ana</creatorcontrib><creatorcontrib>Lara-Padilla, Eleazar</creatorcontrib><creatorcontrib>Cárdenas-Rodríguez, Noemí</creatorcontrib><creatorcontrib>Ignacio-Mejía, Iván</creatorcontrib><creatorcontrib>Martínez-López, Valentín</creatorcontrib><creatorcontrib>Ibañez-Cervantes, Gabriela</creatorcontrib><creatorcontrib>Picado-Garcia, Orlando de Jesús</creatorcontrib><creatorcontrib>Domínguez, Brayan</creatorcontrib><creatorcontrib>Bandala, Cindy</creatorcontrib><title>Effects of Selective and Nonselective Beta Blockers on Bone Mineral Density in Mexican Patients with Breast Cancer</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Breast cancer (BCa) is related to chronic stress and can reduce the bone mineral density (BMD) through neurochemicals related to beta-adrenergic receptor (ADRB) 1 and 2. Selective beta blockers (sBBs) and nonselective beta blockers (nsBBs) are used to treat systemic arterial hypertension (SAH) and may have osteoprotective effects, as they inhibit ADRBs. To evaluate the effects of sBBs and nsBBs on the BMD of Mexican patients with BCa. A retrospective study was conducted. We included 191 Mexican women with BCa without SAH and with SAH treated with nsBBs, sBBs, and diuretics. BMD was evaluated using a bone density scan (DEX scan). A greater average BMD (
< 0.05) was observed in patients with prior treatment with both nsBBs and sBBs (0.54 ± 0.94 and -0.44 ± 1.22, respectively) compared to patients treated with diuretics or without SAH (-1.73 ± 0.83 and -1.22 ± 0.98, respectively). Regarding the diagnosis of osteoporosis/osteopenia, no cases were observed in patients treated with nsBBs, whereas 5.6% of the patients treated with sBBs presented osteopenia. A total of 23.1% and 10.6% patients managed with diuretics or without treatment presented with osteoporosis and 61.5% and 48% patients managed with loop diuretics and without treatment presented with osteopenia, respectively (
< 0.05). Treatment with nsBBs is a promising option for the prevention and management of osteoporosis/osteopenia in Mexican patients with BCa; however, further prospective studies are needed.</description><subject>Adrenergic beta blockers</subject><subject>Adrenergic receptors</subject><subject>Beta blockers</subject><subject>Bone cancer</subject><subject>Bone density</subject><subject>Bone mineral density</subject><subject>Bones</subject><subject>Breast cancer</subject><subject>Catecholamines</subject><subject>Complications and side effects</subject><subject>Density</subject><subject>Disease</subject><subject>Diuretics</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Fractures</subject><subject>Homeostasis</subject><subject>Hypertension</subject><subject>Ligands</subject><subject>Metastasis</subject><subject>Osteopenia</subject><subject>Osteoporosis</subject><subject>Physical activity</subject><subject>Population studies</subject><subject>Quality of life</subject><subject>Receptor density</subject><subject>Risk factors</subject><subject>Software</subject><subject>Standard deviation</subject><subject>Variance analysis</subject><subject>Womens health</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUU1vFSEUJcbGNrVrd4bEjZtXgTsDw8r0PetH0lYTdU14zOWVOg_aYV61_95bW_thhAUnl8O553AZeyHFPoAVb4LPAccqtdSqs_IJ21HCqJnWtnn6AG-zvVrPBC0AabR5xrbBSmu1ljtsPIwRw1R5ifwrDgTTJXKfe35Scr0rzHHyfD6U8IMa8pL5vGTkxynj6Af-DnNN0xVPmR_jr0S--Bc_Jcyk-zNNp3w-oq8TX_wx_JxtRT9U3Ls9d9n394ffFh9nR58_fFocHM1WADDNunYprUDd-A4JGg3RxKhNCK2SoDrV6mh9rwCXIbbSQmx0b1uMXuouLj3ssrc3uueb5Rr7QHbIrDsf09qPV6745B7f5HTqVuXSSQmtalpDCq9vFcZyscE6uXWqAYfBZyyb6kBYKxtlLBD11T_Us7IZM-W7ZpkORCfae9bKD-hSjoUah2tRd9AJ06iGJkOs_f-waPe4ToE-PiaqP3rw8mHSu4h_xwy_ATEFqtg</recordid><startdate>20240820</startdate><enddate>20240820</enddate><creator>Mejía-Barradas, César Miguel</creator><creator>Amador-Martínez, Ana</creator><creator>Lara-Padilla, Eleazar</creator><creator>Cárdenas-Rodríguez, Noemí</creator><creator>Ignacio-Mejía, Iván</creator><creator>Martínez-López, Valentín</creator><creator>Ibañez-Cervantes, Gabriela</creator><creator>Picado-Garcia, Orlando de Jesús</creator><creator>Domínguez, Brayan</creator><creator>Bandala, Cindy</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7269-5257</orcidid><orcidid>https://orcid.org/0000-0003-3792-4613</orcidid><orcidid>https://orcid.org/0000-0002-6580-3440</orcidid><orcidid>https://orcid.org/0000-0001-9607-4327</orcidid></search><sort><creationdate>20240820</creationdate><title>Effects of Selective and Nonselective Beta Blockers on Bone Mineral Density in Mexican Patients with Breast Cancer</title><author>Mejía-Barradas, César Miguel ; Amador-Martínez, Ana ; Lara-Padilla, Eleazar ; Cárdenas-Rodríguez, Noemí ; Ignacio-Mejía, Iván ; Martínez-López, Valentín ; Ibañez-Cervantes, Gabriela ; Picado-Garcia, Orlando de Jesús ; Domínguez, Brayan ; Bandala, Cindy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g333t-85b190e64a8e5b1763f7ff67cc521328256f9ad23ebcf5193f46d95efa168fba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adrenergic beta blockers</topic><topic>Adrenergic receptors</topic><topic>Beta blockers</topic><topic>Bone cancer</topic><topic>Bone density</topic><topic>Bone mineral density</topic><topic>Bones</topic><topic>Breast cancer</topic><topic>Catecholamines</topic><topic>Complications and side effects</topic><topic>Density</topic><topic>Disease</topic><topic>Diuretics</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Fractures</topic><topic>Homeostasis</topic><topic>Hypertension</topic><topic>Ligands</topic><topic>Metastasis</topic><topic>Osteopenia</topic><topic>Osteoporosis</topic><topic>Physical activity</topic><topic>Population studies</topic><topic>Quality of life</topic><topic>Receptor density</topic><topic>Risk factors</topic><topic>Software</topic><topic>Standard deviation</topic><topic>Variance analysis</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mejía-Barradas, César Miguel</creatorcontrib><creatorcontrib>Amador-Martínez, Ana</creatorcontrib><creatorcontrib>Lara-Padilla, Eleazar</creatorcontrib><creatorcontrib>Cárdenas-Rodríguez, Noemí</creatorcontrib><creatorcontrib>Ignacio-Mejía, Iván</creatorcontrib><creatorcontrib>Martínez-López, Valentín</creatorcontrib><creatorcontrib>Ibañez-Cervantes, Gabriela</creatorcontrib><creatorcontrib>Picado-Garcia, Orlando de Jesús</creatorcontrib><creatorcontrib>Domínguez, Brayan</creatorcontrib><creatorcontrib>Bandala, Cindy</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mejía-Barradas, César Miguel</au><au>Amador-Martínez, Ana</au><au>Lara-Padilla, Eleazar</au><au>Cárdenas-Rodríguez, Noemí</au><au>Ignacio-Mejía, Iván</au><au>Martínez-López, Valentín</au><au>Ibañez-Cervantes, Gabriela</au><au>Picado-Garcia, Orlando de Jesús</au><au>Domínguez, Brayan</au><au>Bandala, Cindy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Selective and Nonselective Beta Blockers on Bone Mineral Density in Mexican Patients with Breast Cancer</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2024-08-20</date><risdate>2024</risdate><volume>16</volume><issue>16</issue><spage>2891</spage><pages>2891-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Breast cancer (BCa) is related to chronic stress and can reduce the bone mineral density (BMD) through neurochemicals related to beta-adrenergic receptor (ADRB) 1 and 2. Selective beta blockers (sBBs) and nonselective beta blockers (nsBBs) are used to treat systemic arterial hypertension (SAH) and may have osteoprotective effects, as they inhibit ADRBs. To evaluate the effects of sBBs and nsBBs on the BMD of Mexican patients with BCa. A retrospective study was conducted. We included 191 Mexican women with BCa without SAH and with SAH treated with nsBBs, sBBs, and diuretics. BMD was evaluated using a bone density scan (DEX scan). A greater average BMD (
< 0.05) was observed in patients with prior treatment with both nsBBs and sBBs (0.54 ± 0.94 and -0.44 ± 1.22, respectively) compared to patients treated with diuretics or without SAH (-1.73 ± 0.83 and -1.22 ± 0.98, respectively). Regarding the diagnosis of osteoporosis/osteopenia, no cases were observed in patients treated with nsBBs, whereas 5.6% of the patients treated with sBBs presented osteopenia. A total of 23.1% and 10.6% patients managed with diuretics or without treatment presented with osteoporosis and 61.5% and 48% patients managed with loop diuretics and without treatment presented with osteopenia, respectively (
< 0.05). Treatment with nsBBs is a promising option for the prevention and management of osteoporosis/osteopenia in Mexican patients with BCa; however, further prospective studies are needed.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39199661</pmid><doi>10.3390/cancers16162891</doi><orcidid>https://orcid.org/0000-0002-7269-5257</orcidid><orcidid>https://orcid.org/0000-0003-3792-4613</orcidid><orcidid>https://orcid.org/0000-0002-6580-3440</orcidid><orcidid>https://orcid.org/0000-0001-9607-4327</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenergic beta blockers Adrenergic receptors Beta blockers Bone cancer Bone density Bone mineral density Bones Breast cancer Catecholamines Complications and side effects Density Disease Diuretics Dosage and administration Drug therapy Fractures Homeostasis Hypertension Ligands Metastasis Osteopenia Osteoporosis Physical activity Population studies Quality of life Receptor density Risk factors Software Standard deviation Variance analysis Womens health |
| title | Effects of Selective and Nonselective Beta Blockers on Bone Mineral Density in Mexican Patients with Breast Cancer |
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