Perioperative chemotherapy with nivolumab for HER2-negative locally advanced gastric cancer: a case series
Background Nivolumab with chemotherapy has been transformative for metastatic gastric cancer (GC). The potential of this regimen for local tumor control could be utilized for perioperative chemotherapy in locally advanced GC with bulky tumors or lymph node metastasis involving other organs. Case pre...
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| Veröffentlicht in: | Surgical Case Reports 2024-08, Vol.10 (1), p.200, Article 200 |
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| creator | Toji, Yuta Takeuchi, Shintaro Ebihara, Yuma Kurashima, Yo Harada, Kazuaki Hayashi, Mariko Abe, Hirotake Wada, Hideyuki Yorinaga, Satoko Shichinohe, Toshiaki Tomaru, Utano Komatsu, Yoshito Hirano, Satoshi |
| description | Background
Nivolumab with chemotherapy has been transformative for metastatic gastric cancer (GC). The potential of this regimen for local tumor control could be utilized for perioperative chemotherapy in locally advanced GC with bulky tumors or lymph node metastasis involving other organs.
Case presentation
Five patients with HER2-negative advanced GC were treated with nivolumab and oxaliplatin-based chemotherapy. All patients presented with clinical stage III or IVA GC with tumors in contact with either the pancreas or liver. Following chemotherapy, all tumors demonstrated shrinkage, allowing successful radical gastrectomies including four minimally invasive approach without postoperative complications. Four patients avoided combined resection of other organs.
Conclusions
Perioperative chemotherapy with nivolumab was effective for local disease control in this case series. This regimen could be a promising treatment approach for locally advanced GC; however, its survival benefits should be evaluated in clinical trials. |
| doi_str_mv | 10.1186/s40792-024-02001-w |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11349963</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A810294958</galeid><sourcerecordid>A810294958</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-7fa7eae68a45e2884cbc3cb9d89f1922460a2f59021d885bde5454ea059005bb3</originalsourceid><addsrcrecordid>eNp9kctq3DAUhk1oaUKaF-giCLrpxqkky7bUTQkhbQqBltKshSwfezTY0lSyZ5i3z5k4SdMuihA6l-9cxJ9l7xi9YExWH5OgteI55QIvpSzfHWUnnCmZ17UqXr2wj7OzlNYUmZJLqdib7LhQTHGq6Em2_gHRhQ1EM7ktELuCMUwrdDd7snPTini3DcM8moZ0IZKb658899Av9BCsGYY9Me3WeAst6U2aorPEHtz4iRi0EpCEMyC9zV53Zkhw9vieZndfrn9d3eS3379-u7q8za3gxZTXnanBQCWNKAEXFraxhW1UK1WHW3NRUcO7UlHOWinLpoVSlAIMxRAtm6Y4zT4vfTdzM0JrwU_RDHoT3WjiXgfj9N8Z71a6D1vNWCGUqgrs8OGxQwy_Z0iTHl2yMAzGQ5iTLqiqZUmlUoi-_wddhzl6_N8DVfGaSonUxUL1ZgDtfBdwsMXTwuhs8NA5jF9KRrkSqjwU8KXAxpBShO55fUb1QX-96K9Rf_2gv95h0fnLjz-XPKmNQLEACVO-h_hn2f-0vQeJi7zN</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3097627088</pqid></control><display><type>article</type><title>Perioperative chemotherapy with nivolumab for HER2-negative locally advanced gastric cancer: a case series</title><source>DOAJ Directory of Open Access Journals</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><source>PubMed Central</source><creator>Toji, Yuta ; Takeuchi, Shintaro ; Ebihara, Yuma ; Kurashima, Yo ; Harada, Kazuaki ; Hayashi, Mariko ; Abe, Hirotake ; Wada, Hideyuki ; Yorinaga, Satoko ; Shichinohe, Toshiaki ; Tomaru, Utano ; Komatsu, Yoshito ; Hirano, Satoshi</creator><creatorcontrib>Toji, Yuta ; Takeuchi, Shintaro ; Ebihara, Yuma ; Kurashima, Yo ; Harada, Kazuaki ; Hayashi, Mariko ; Abe, Hirotake ; Wada, Hideyuki ; Yorinaga, Satoko ; Shichinohe, Toshiaki ; Tomaru, Utano ; Komatsu, Yoshito ; Hirano, Satoshi</creatorcontrib><description>Background
Nivolumab with chemotherapy has been transformative for metastatic gastric cancer (GC). The potential of this regimen for local tumor control could be utilized for perioperative chemotherapy in locally advanced GC with bulky tumors or lymph node metastasis involving other organs.
Case presentation
Five patients with HER2-negative advanced GC were treated with nivolumab and oxaliplatin-based chemotherapy. All patients presented with clinical stage III or IVA GC with tumors in contact with either the pancreas or liver. Following chemotherapy, all tumors demonstrated shrinkage, allowing successful radical gastrectomies including four minimally invasive approach without postoperative complications. Four patients avoided combined resection of other organs.
Conclusions
Perioperative chemotherapy with nivolumab was effective for local disease control in this case series. This regimen could be a promising treatment approach for locally advanced GC; however, its survival benefits should be evaluated in clinical trials.</description><identifier>ISSN: 2198-7793</identifier><identifier>EISSN: 2198-7793</identifier><identifier>DOI: 10.1186/s40792-024-02001-w</identifier><identifier>PMID: 39192090</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer ; Cancer therapies ; Care and treatment ; Case Report ; Case reports ; Cell death ; Chemotherapy ; Classification ; Epidermal growth factor ; Gastric cancer ; Hormone replacement therapy ; Ligands ; Liver ; Liver cancer ; Lymphatic system ; Medicine ; Medicine & Public Health ; Metastasis ; Pancreaticoduodenectomy ; Patients ; Stomach cancer ; Surgery ; Tumors</subject><ispartof>Surgical Case Reports, 2024-08, Vol.10 (1), p.200, Article 200</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>COPYRIGHT 2024 Springer</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c423t-7fa7eae68a45e2884cbc3cb9d89f1922460a2f59021d885bde5454ea059005bb3</cites><orcidid>0000-0001-7299-2342</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349963/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349963/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,41488,42189,42557,51319,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39192090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toji, Yuta</creatorcontrib><creatorcontrib>Takeuchi, Shintaro</creatorcontrib><creatorcontrib>Ebihara, Yuma</creatorcontrib><creatorcontrib>Kurashima, Yo</creatorcontrib><creatorcontrib>Harada, Kazuaki</creatorcontrib><creatorcontrib>Hayashi, Mariko</creatorcontrib><creatorcontrib>Abe, Hirotake</creatorcontrib><creatorcontrib>Wada, Hideyuki</creatorcontrib><creatorcontrib>Yorinaga, Satoko</creatorcontrib><creatorcontrib>Shichinohe, Toshiaki</creatorcontrib><creatorcontrib>Tomaru, Utano</creatorcontrib><creatorcontrib>Komatsu, Yoshito</creatorcontrib><creatorcontrib>Hirano, Satoshi</creatorcontrib><title>Perioperative chemotherapy with nivolumab for HER2-negative locally advanced gastric cancer: a case series</title><title>Surgical Case Reports</title><addtitle>surg case rep</addtitle><addtitle>Surg Case Rep</addtitle><description>Background
Nivolumab with chemotherapy has been transformative for metastatic gastric cancer (GC). The potential of this regimen for local tumor control could be utilized for perioperative chemotherapy in locally advanced GC with bulky tumors or lymph node metastasis involving other organs.
Case presentation
Five patients with HER2-negative advanced GC were treated with nivolumab and oxaliplatin-based chemotherapy. All patients presented with clinical stage III or IVA GC with tumors in contact with either the pancreas or liver. Following chemotherapy, all tumors demonstrated shrinkage, allowing successful radical gastrectomies including four minimally invasive approach without postoperative complications. Four patients avoided combined resection of other organs.
Conclusions
Perioperative chemotherapy with nivolumab was effective for local disease control in this case series. This regimen could be a promising treatment approach for locally advanced GC; however, its survival benefits should be evaluated in clinical trials.</description><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Cell death</subject><subject>Chemotherapy</subject><subject>Classification</subject><subject>Epidermal growth factor</subject><subject>Gastric cancer</subject><subject>Hormone replacement therapy</subject><subject>Ligands</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Lymphatic system</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Pancreaticoduodenectomy</subject><subject>Patients</subject><subject>Stomach cancer</subject><subject>Surgery</subject><subject>Tumors</subject><issn>2198-7793</issn><issn>2198-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kctq3DAUhk1oaUKaF-giCLrpxqkky7bUTQkhbQqBltKshSwfezTY0lSyZ5i3z5k4SdMuihA6l-9cxJ9l7xi9YExWH5OgteI55QIvpSzfHWUnnCmZ17UqXr2wj7OzlNYUmZJLqdib7LhQTHGq6Em2_gHRhQ1EM7ktELuCMUwrdDd7snPTini3DcM8moZ0IZKb658899Av9BCsGYY9Me3WeAst6U2aorPEHtz4iRi0EpCEMyC9zV53Zkhw9vieZndfrn9d3eS3379-u7q8za3gxZTXnanBQCWNKAEXFraxhW1UK1WHW3NRUcO7UlHOWinLpoVSlAIMxRAtm6Y4zT4vfTdzM0JrwU_RDHoT3WjiXgfj9N8Z71a6D1vNWCGUqgrs8OGxQwy_Z0iTHl2yMAzGQ5iTLqiqZUmlUoi-_wddhzl6_N8DVfGaSonUxUL1ZgDtfBdwsMXTwuhs8NA5jF9KRrkSqjwU8KXAxpBShO55fUb1QX-96K9Rf_2gv95h0fnLjz-XPKmNQLEACVO-h_hn2f-0vQeJi7zN</recordid><startdate>20240828</startdate><enddate>20240828</enddate><creator>Toji, Yuta</creator><creator>Takeuchi, Shintaro</creator><creator>Ebihara, Yuma</creator><creator>Kurashima, Yo</creator><creator>Harada, Kazuaki</creator><creator>Hayashi, Mariko</creator><creator>Abe, Hirotake</creator><creator>Wada, Hideyuki</creator><creator>Yorinaga, Satoko</creator><creator>Shichinohe, Toshiaki</creator><creator>Tomaru, Utano</creator><creator>Komatsu, Yoshito</creator><creator>Hirano, Satoshi</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7299-2342</orcidid></search><sort><creationdate>20240828</creationdate><title>Perioperative chemotherapy with nivolumab for HER2-negative locally advanced gastric cancer: a case series</title><author>Toji, Yuta ; Takeuchi, Shintaro ; Ebihara, Yuma ; Kurashima, Yo ; Harada, Kazuaki ; Hayashi, Mariko ; Abe, Hirotake ; Wada, Hideyuki ; Yorinaga, Satoko ; Shichinohe, Toshiaki ; Tomaru, Utano ; Komatsu, Yoshito ; Hirano, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-7fa7eae68a45e2884cbc3cb9d89f1922460a2f59021d885bde5454ea059005bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Cell death</topic><topic>Chemotherapy</topic><topic>Classification</topic><topic>Epidermal growth factor</topic><topic>Gastric cancer</topic><topic>Hormone replacement therapy</topic><topic>Ligands</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Lymphatic system</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Pancreaticoduodenectomy</topic><topic>Patients</topic><topic>Stomach cancer</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toji, Yuta</creatorcontrib><creatorcontrib>Takeuchi, Shintaro</creatorcontrib><creatorcontrib>Ebihara, Yuma</creatorcontrib><creatorcontrib>Kurashima, Yo</creatorcontrib><creatorcontrib>Harada, Kazuaki</creatorcontrib><creatorcontrib>Hayashi, Mariko</creatorcontrib><creatorcontrib>Abe, Hirotake</creatorcontrib><creatorcontrib>Wada, Hideyuki</creatorcontrib><creatorcontrib>Yorinaga, Satoko</creatorcontrib><creatorcontrib>Shichinohe, Toshiaki</creatorcontrib><creatorcontrib>Tomaru, Utano</creatorcontrib><creatorcontrib>Komatsu, Yoshito</creatorcontrib><creatorcontrib>Hirano, Satoshi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Surgical Case Reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toji, Yuta</au><au>Takeuchi, Shintaro</au><au>Ebihara, Yuma</au><au>Kurashima, Yo</au><au>Harada, Kazuaki</au><au>Hayashi, Mariko</au><au>Abe, Hirotake</au><au>Wada, Hideyuki</au><au>Yorinaga, Satoko</au><au>Shichinohe, Toshiaki</au><au>Tomaru, Utano</au><au>Komatsu, Yoshito</au><au>Hirano, Satoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perioperative chemotherapy with nivolumab for HER2-negative locally advanced gastric cancer: a case series</atitle><jtitle>Surgical Case Reports</jtitle><stitle>surg case rep</stitle><addtitle>Surg Case Rep</addtitle><date>2024-08-28</date><risdate>2024</risdate><volume>10</volume><issue>1</issue><spage>200</spage><pages>200-</pages><artnum>200</artnum><issn>2198-7793</issn><eissn>2198-7793</eissn><abstract>Background
Nivolumab with chemotherapy has been transformative for metastatic gastric cancer (GC). The potential of this regimen for local tumor control could be utilized for perioperative chemotherapy in locally advanced GC with bulky tumors or lymph node metastasis involving other organs.
Case presentation
Five patients with HER2-negative advanced GC were treated with nivolumab and oxaliplatin-based chemotherapy. All patients presented with clinical stage III or IVA GC with tumors in contact with either the pancreas or liver. Following chemotherapy, all tumors demonstrated shrinkage, allowing successful radical gastrectomies including four minimally invasive approach without postoperative complications. Four patients avoided combined resection of other organs.
Conclusions
Perioperative chemotherapy with nivolumab was effective for local disease control in this case series. This regimen could be a promising treatment approach for locally advanced GC; however, its survival benefits should be evaluated in clinical trials.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39192090</pmid><doi>10.1186/s40792-024-02001-w</doi><orcidid>https://orcid.org/0000-0001-7299-2342</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Springer Nature OA Free Journals; PubMed Central |
| subjects | Cancer Cancer therapies Care and treatment Case Report Case reports Cell death Chemotherapy Classification Epidermal growth factor Gastric cancer Hormone replacement therapy Ligands Liver Liver cancer Lymphatic system Medicine Medicine & Public Health Metastasis Pancreaticoduodenectomy Patients Stomach cancer Surgery Tumors |
| title | Perioperative chemotherapy with nivolumab for HER2-negative locally advanced gastric cancer: a case series |
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