Synthesis and antibacterial action of 3’,6’-disubstituted spectinomycins

Spectinomycin is an aminocyclitol antibiotic with a unique ribosomal binding site. Prior synthetic modifications of spectinomycin have enhanced potency and antibacterial spectrum through addition at the 6’-position to produce trospectomycin and to the 3’-position to produce spectinamides and aminome...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 2024-09, Vol.77 (9), p.577-588
Hauptverfasser:	Dharuman, Suresh, Phelps, Gregory A., Dunn, Christine M., Wilt, Laura A., Murphy, Patricia A., Lee, Robin B., Snoke, Hannah E., Selchow, Petra, Haldimann, Klara, Böttger, Erik C., Hobbie, Sven N., Sander, Peter, Lee, Richard E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/22/1290 639/638/309/2144 Analogs Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antiinfectives and antibacterials Bacteria - drug effects Bacteriology Binding Sites Biomedical and Life Sciences Bioorganic Chemistry Effectiveness Efflux Ethylene Life Sciences Medicinal Chemistry Microbial Sensitivity Tests Microbiology Organic Chemistry Ribosomes - drug effects Ribosomes - metabolism Spectinomycin Spectinomycin - analogs & derivatives Spectinomycin - chemical synthesis Spectinomycin - pharmacology Structure-Activity Relationship Synthesis Trospectomycin Tuberculosis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!