Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities

Peptides that form transmembrane barrel-stave pores are potential alternative therapeutics for bacterial infections and cancer. However, their optimization for clinical translation is hampered by a lack of sequence-function understanding. Recently, we have de novo designed the first synthetic barrel...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2024-08, Vol.67 (16), p.14040-14061
Hauptverfasser:	Deb, Rahul, Torres, Marcelo D. T., Boudný, Miroslav, Koběrská, Markéta, Cappiello, Floriana, Popper, Miroslav, Dvořáková Bendová, Kateřina, Drabinová, Martina, Hanáčková, Adelheid, Jeannot, Katy, Petřík, Miloš, Mangoni, Maria Luisa, Balíková Novotná, Gabriela, Mráz, Marek, de la Fuente-Nunez, Cesar, Vácha, Robert
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!