Postnatal growth and neurodevelopment at 2 years’ corrected age in extremely low birthweight infants
Background Faltering postnatal growth in preterm babies is associated with adverse neurodevelopment. However, which growth reference is most helpful for predicting neurodevelopment is unknown. We examined associations between faltering growth and developmental delay in extremely low birthweight (ELB...
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| Veröffentlicht in: | Pediatric research 2024-07, Vol.96 (2), p.436-449 |
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| creator | Nyakotey, David A. Clarke, Angelica M. Cormack, Barbara E. Bloomfield, Frank H. Harding, Jane E. |
| description | Background
Faltering postnatal growth in preterm babies is associated with adverse neurodevelopment. However, which growth reference is most helpful for predicting neurodevelopment is unknown. We examined associations between faltering growth and developmental delay in extremely low birthweight (ELBW) infants.
Methods
We categorized faltering growth (z-score decrease ≥0.8 for weight/length, >1 for head circumference) between birth, 4 weeks, 36 weeks’ postmenstrual age and 2 years’ corrected age using fetal (Fenton, UK-WHO and Olsen) and healthy preterm (INTERGROWTH-21st) references. Associations between faltering growth and developmental delay were examined using binary logistic regression and area under the receiver operating curve (AUC).
Results
In 327 infants, Olsen charts identified the highest prevalence of faltering growth (weight 37%, length 63%, head 45%). Agreement in classification was higher amongst fetal references (kappa coefficient,
ĸ
= 0.46–0.94) than between INTERGROWTH-21st and fetal references (
ĸ
= 0.10–0.81). Faltering growth in all measures between 4–36 weeks (odds ratio, OR 2.0–4.7) compared with other time intervals (OR 1.7–2.7) were more strongly associated with developmental delay, particularly motor delay (OR 2.0–4.7). All growth references were poorly predictive of developmental delay at 2 years (AUC ≤ 0.62).
Conclusions
Faltering postnatal growth in ELBW infants is associated with, but is poorly predictive of, developmental delay at 2 years.
Impact
In babies born preterm, different growth references result in wide variation in categorization of faltering postnatal growth.
Faltering growth in weight, length, and head circumference from 4 weeks to 36 weeks’ postmenstrual age are associated with developmental delay at 2 years’ corrected age, particularly motor delay.
However, postnatal growth is a poor predictor of later developmental delay in extremely low birthweight infants irrespective of the growth reference used. |
| doi_str_mv | 10.1038/s41390-024-03054-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11343699</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3096450432</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-d48ed5390f27b7693f9c37e394b0df24b350f347d04ec295cb0e7a5c72cf6d923</originalsourceid><addsrcrecordid>eNp9UcuO1DAQtBCIHRZ-gAOyxIVLwHbbSXxCaMVLWgkOcLYcp5PJKrEH29nZufEb_B5fgpdZlseBU0td1dVVKkIec_acM2hfJMlBs4oJWTFgSlb8DtlwBWUlZXOXbBgDXoHW7Ql5kNIFY1yqVt4nJ9ACNEzyDRk-hpS9zXamYwz7vKXW99TjGkOPlziH3YI-U5upoAe0MX3_-o26ECO6jD21I9LJU7zKERecD3QOe9pNMW_3OI3bXMDB-pweknuDnRM-upmn5POb15_O3lXnH96-P3t1XjlQda562WKvSqhBNF1Taxi0gwZBy471g5AdKDaAbHom0QmtXMewsco1wg11rwWckpdH3d3aLdi74j3a2ezitNh4MMFO5m_ET1szhkvDOUiotS4Kz24UYviyYspmmZLDebYew5qM0EIxkLxtCvXpP9SLsEZf8hlgupaKSbi2JI4sF0NKEYdbN5yZ6x7NsUdTejQ_ezS8HD35M8ftya_iCgGOhFQgP2L8_fs_sj8AEparVQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3096450432</pqid></control><display><type>article</type><title>Postnatal growth and neurodevelopment at 2 years’ corrected age in extremely low birthweight infants</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Nyakotey, David A. ; Clarke, Angelica M. ; Cormack, Barbara E. ; Bloomfield, Frank H. ; Harding, Jane E.</creator><creatorcontrib>Nyakotey, David A. ; Clarke, Angelica M. ; Cormack, Barbara E. ; Bloomfield, Frank H. ; Harding, Jane E. ; ProVIDe Study Group ; on behalf of the ProVIDe Study Group ; Steering Group ; Investigators</creatorcontrib><description>Background
Faltering postnatal growth in preterm babies is associated with adverse neurodevelopment. However, which growth reference is most helpful for predicting neurodevelopment is unknown. We examined associations between faltering growth and developmental delay in extremely low birthweight (ELBW) infants.
Methods
We categorized faltering growth (z-score decrease ≥0.8 for weight/length, >1 for head circumference) between birth, 4 weeks, 36 weeks’ postmenstrual age and 2 years’ corrected age using fetal (Fenton, UK-WHO and Olsen) and healthy preterm (INTERGROWTH-21st) references. Associations between faltering growth and developmental delay were examined using binary logistic regression and area under the receiver operating curve (AUC).
Results
In 327 infants, Olsen charts identified the highest prevalence of faltering growth (weight 37%, length 63%, head 45%). Agreement in classification was higher amongst fetal references (kappa coefficient,
ĸ
= 0.46–0.94) than between INTERGROWTH-21st and fetal references (
ĸ
= 0.10–0.81). Faltering growth in all measures between 4–36 weeks (odds ratio, OR 2.0–4.7) compared with other time intervals (OR 1.7–2.7) were more strongly associated with developmental delay, particularly motor delay (OR 2.0–4.7). All growth references were poorly predictive of developmental delay at 2 years (AUC ≤ 0.62).
Conclusions
Faltering postnatal growth in ELBW infants is associated with, but is poorly predictive of, developmental delay at 2 years.
Impact
In babies born preterm, different growth references result in wide variation in categorization of faltering postnatal growth.
Faltering growth in weight, length, and head circumference from 4 weeks to 36 weeks’ postmenstrual age are associated with developmental delay at 2 years’ corrected age, particularly motor delay.
However, postnatal growth is a poor predictor of later developmental delay in extremely low birthweight infants irrespective of the growth reference used.</description><identifier>ISSN: 0031-3998</identifier><identifier>ISSN: 1530-0447</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-024-03054-1</identifier><identifier>PMID: 38337041</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Babies ; Birth Weight ; Child Development ; Child, Preschool ; Clinical ; Clinical Research Article ; Developmental Disabilities - epidemiology ; Female ; Gestational Age ; Growth Charts ; Humans ; Infant ; Infant, Extremely Low Birth Weight - growth & development ; Infant, Newborn ; Infant, Premature - growth & development ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Neurodevelopmental disorders ; Pediatric Surgery ; Pediatrics ; Postpartum period ; Regression analysis</subject><ispartof>Pediatric research, 2024-07, Vol.96 (2), p.436-449</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-d48ed5390f27b7693f9c37e394b0df24b350f347d04ec295cb0e7a5c72cf6d923</cites><orcidid>0000-0003-2697-1422</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41390-024-03054-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41390-024-03054-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38337041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nyakotey, David A.</creatorcontrib><creatorcontrib>Clarke, Angelica M.</creatorcontrib><creatorcontrib>Cormack, Barbara E.</creatorcontrib><creatorcontrib>Bloomfield, Frank H.</creatorcontrib><creatorcontrib>Harding, Jane E.</creatorcontrib><creatorcontrib>ProVIDe Study Group</creatorcontrib><creatorcontrib>on behalf of the ProVIDe Study Group</creatorcontrib><creatorcontrib>Steering Group</creatorcontrib><creatorcontrib>Investigators</creatorcontrib><title>Postnatal growth and neurodevelopment at 2 years’ corrected age in extremely low birthweight infants</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Faltering postnatal growth in preterm babies is associated with adverse neurodevelopment. However, which growth reference is most helpful for predicting neurodevelopment is unknown. We examined associations between faltering growth and developmental delay in extremely low birthweight (ELBW) infants.
Methods
We categorized faltering growth (z-score decrease ≥0.8 for weight/length, >1 for head circumference) between birth, 4 weeks, 36 weeks’ postmenstrual age and 2 years’ corrected age using fetal (Fenton, UK-WHO and Olsen) and healthy preterm (INTERGROWTH-21st) references. Associations between faltering growth and developmental delay were examined using binary logistic regression and area under the receiver operating curve (AUC).
Results
In 327 infants, Olsen charts identified the highest prevalence of faltering growth (weight 37%, length 63%, head 45%). Agreement in classification was higher amongst fetal references (kappa coefficient,
ĸ
= 0.46–0.94) than between INTERGROWTH-21st and fetal references (
ĸ
= 0.10–0.81). Faltering growth in all measures between 4–36 weeks (odds ratio, OR 2.0–4.7) compared with other time intervals (OR 1.7–2.7) were more strongly associated with developmental delay, particularly motor delay (OR 2.0–4.7). All growth references were poorly predictive of developmental delay at 2 years (AUC ≤ 0.62).
Conclusions
Faltering postnatal growth in ELBW infants is associated with, but is poorly predictive of, developmental delay at 2 years.
Impact
In babies born preterm, different growth references result in wide variation in categorization of faltering postnatal growth.
Faltering growth in weight, length, and head circumference from 4 weeks to 36 weeks’ postmenstrual age are associated with developmental delay at 2 years’ corrected age, particularly motor delay.
However, postnatal growth is a poor predictor of later developmental delay in extremely low birthweight infants irrespective of the growth reference used.</description><subject>Babies</subject><subject>Birth Weight</subject><subject>Child Development</subject><subject>Child, Preschool</subject><subject>Clinical</subject><subject>Clinical Research Article</subject><subject>Developmental Disabilities - epidemiology</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Growth Charts</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Extremely Low Birth Weight - growth & development</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - growth & development</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurodevelopmental disorders</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Postpartum period</subject><subject>Regression analysis</subject><issn>0031-3998</issn><issn>1530-0447</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9UcuO1DAQtBCIHRZ-gAOyxIVLwHbbSXxCaMVLWgkOcLYcp5PJKrEH29nZufEb_B5fgpdZlseBU0td1dVVKkIec_acM2hfJMlBs4oJWTFgSlb8DtlwBWUlZXOXbBgDXoHW7Ql5kNIFY1yqVt4nJ9ACNEzyDRk-hpS9zXamYwz7vKXW99TjGkOPlziH3YI-U5upoAe0MX3_-o26ECO6jD21I9LJU7zKERecD3QOe9pNMW_3OI3bXMDB-pweknuDnRM-upmn5POb15_O3lXnH96-P3t1XjlQda562WKvSqhBNF1Taxi0gwZBy471g5AdKDaAbHom0QmtXMewsco1wg11rwWckpdH3d3aLdi74j3a2ezitNh4MMFO5m_ET1szhkvDOUiotS4Kz24UYviyYspmmZLDebYew5qM0EIxkLxtCvXpP9SLsEZf8hlgupaKSbi2JI4sF0NKEYdbN5yZ6x7NsUdTejQ_ezS8HD35M8ftya_iCgGOhFQgP2L8_fs_sj8AEparVQ</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Nyakotey, David A.</creator><creator>Clarke, Angelica M.</creator><creator>Cormack, Barbara E.</creator><creator>Bloomfield, Frank H.</creator><creator>Harding, Jane E.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2697-1422</orcidid></search><sort><creationdate>202407</creationdate><title>Postnatal growth and neurodevelopment at 2 years’ corrected age in extremely low birthweight infants</title><author>Nyakotey, David A. ; Clarke, Angelica M. ; Cormack, Barbara E. ; Bloomfield, Frank H. ; Harding, Jane E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-d48ed5390f27b7693f9c37e394b0df24b350f347d04ec295cb0e7a5c72cf6d923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Babies</topic><topic>Birth Weight</topic><topic>Child Development</topic><topic>Child, Preschool</topic><topic>Clinical</topic><topic>Clinical Research Article</topic><topic>Developmental Disabilities - epidemiology</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Growth Charts</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Extremely Low Birth Weight - growth & development</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - growth & development</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurodevelopmental disorders</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Postpartum period</topic><topic>Regression analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nyakotey, David A.</creatorcontrib><creatorcontrib>Clarke, Angelica M.</creatorcontrib><creatorcontrib>Cormack, Barbara E.</creatorcontrib><creatorcontrib>Bloomfield, Frank H.</creatorcontrib><creatorcontrib>Harding, Jane E.</creatorcontrib><creatorcontrib>ProVIDe Study Group</creatorcontrib><creatorcontrib>on behalf of the ProVIDe Study Group</creatorcontrib><creatorcontrib>Steering Group</creatorcontrib><creatorcontrib>Investigators</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nyakotey, David A.</au><au>Clarke, Angelica M.</au><au>Cormack, Barbara E.</au><au>Bloomfield, Frank H.</au><au>Harding, Jane E.</au><aucorp>ProVIDe Study Group</aucorp><aucorp>on behalf of the ProVIDe Study Group</aucorp><aucorp>Steering Group</aucorp><aucorp>Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postnatal growth and neurodevelopment at 2 years’ corrected age in extremely low birthweight infants</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2024-07</date><risdate>2024</risdate><volume>96</volume><issue>2</issue><spage>436</spage><epage>449</epage><pages>436-449</pages><issn>0031-3998</issn><issn>1530-0447</issn><eissn>1530-0447</eissn><abstract>Background
Faltering postnatal growth in preterm babies is associated with adverse neurodevelopment. However, which growth reference is most helpful for predicting neurodevelopment is unknown. We examined associations between faltering growth and developmental delay in extremely low birthweight (ELBW) infants.
Methods
We categorized faltering growth (z-score decrease ≥0.8 for weight/length, >1 for head circumference) between birth, 4 weeks, 36 weeks’ postmenstrual age and 2 years’ corrected age using fetal (Fenton, UK-WHO and Olsen) and healthy preterm (INTERGROWTH-21st) references. Associations between faltering growth and developmental delay were examined using binary logistic regression and area under the receiver operating curve (AUC).
Results
In 327 infants, Olsen charts identified the highest prevalence of faltering growth (weight 37%, length 63%, head 45%). Agreement in classification was higher amongst fetal references (kappa coefficient,
ĸ
= 0.46–0.94) than between INTERGROWTH-21st and fetal references (
ĸ
= 0.10–0.81). Faltering growth in all measures between 4–36 weeks (odds ratio, OR 2.0–4.7) compared with other time intervals (OR 1.7–2.7) were more strongly associated with developmental delay, particularly motor delay (OR 2.0–4.7). All growth references were poorly predictive of developmental delay at 2 years (AUC ≤ 0.62).
Conclusions
Faltering postnatal growth in ELBW infants is associated with, but is poorly predictive of, developmental delay at 2 years.
Impact
In babies born preterm, different growth references result in wide variation in categorization of faltering postnatal growth.
Faltering growth in weight, length, and head circumference from 4 weeks to 36 weeks’ postmenstrual age are associated with developmental delay at 2 years’ corrected age, particularly motor delay.
However, postnatal growth is a poor predictor of later developmental delay in extremely low birthweight infants irrespective of the growth reference used.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>38337041</pmid><doi>10.1038/s41390-024-03054-1</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-2697-1422</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Babies Birth Weight Child Development Child, Preschool Clinical Clinical Research Article Developmental Disabilities - epidemiology Female Gestational Age Growth Charts Humans Infant Infant, Extremely Low Birth Weight - growth & development Infant, Newborn Infant, Premature - growth & development Logistic Models Male Medicine Medicine & Public Health Neurodevelopmental disorders Pediatric Surgery Pediatrics Postpartum period Regression analysis |
| title | Postnatal growth and neurodevelopment at 2 years’ corrected age in extremely low birthweight infants |
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