A class-A β-lactamase from Pseudomonas stutzeri that is highly active against monobactams and cefotaxime

A beta-lactamase produced by Pseudomonas stutzeri was purified to protein homogeneity, and its physicochemical and catalytic properties were determined. Its profile was unusual since, in addition to penicillins, the enzyme hydrolysed second- and third-generation 'beta-lactamase-stable' cep...

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Veröffentlicht in:	Biochemical journal 1993-06, Vol.292 (3), p.697-700
Hauptverfasser:	FRANCESCHINI, N, GALLENI, M, FRERE, J.-M, ORATORE, A, AMICOSANTE, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry beta-Lactamases - isolation & purification beta-Lactamases - metabolism beta-Lactamases/isolation & purification/metabolism Biochemistry, biophysics & molecular biology Biochimie, biophysique & biologie moléculaire Biological and medical sciences Cefotaxime - metabolism Chromatography, Affinity Chromatography, Gel Electrophoresis, Polyacrylamide Gel Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases Isoenzymes - isolation & purification Isoenzymes - metabolism Isoenzymes/isolation & purification/metabolism Kinetics Life sciences Monobactams - metabolism Pseudomonas - enzymology Sciences du vivant Substrate Specificity
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