Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2

Gab2 (Grb2-associated binder-2), a member of the IRS (insulin receptor substrate)/Gab family of adapter proteins, undergoes tyrosine phosphorylation in response to cytokine or growth factor stimulation and serves as a docking platform for many signal transduction effectors, including the tyrosine ph...

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Veröffentlicht in:	Biochemical journal 2004-09, Vol.382 (Pt 2), p.545-556
Hauptverfasser:	Arnaud, Mary, Mzali, Rym, Gesbert, Franck, Crouin, Catherine, Guenzi, Christine, Vermot-Desroches, Claudine, Wijdenes, John, Courtois, Geneviève, Bernard, Olivier, Bertoglio, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - physiology Adaptor Proteins, Signal Transducing CCAAT-Binding Factor - physiology Cell Line, Tumor Gene Expression Regulation - physiology Gene Expression Regulation, Enzymologic - physiology Genes, fos - physiology Glutathione Transferase Humans Interleukin-2 - physiology Intracellular Signaling Peptides and Proteins Leukemia, Prolymphocytic, T-Cell - pathology Mitogen-Activated Protein Kinase Kinases - physiology Mitogen-Activated Protein Kinases - physiology Peptides - metabolism Phosphoproteins - metabolism Protein Structure, Tertiary Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatases - metabolism Protein Tyrosine Phosphatases - physiology Serum Response Element - physiology SH2 Domain-Containing Protein Tyrosine Phosphatases Signal Transduction - physiology src Homology Domains - physiology T-Lymphocytes - enzymology T-Lymphocytes - physiology Tyrosine - metabolism Tyrosine - physiology
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