Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes

Despite experimental evidence that sulforaphane can exert chemopreventive effects, whether these effects are specific for neoplastic cells is not known. Following our previous demonstration that sulforaphane induces cell cycle arrest and apoptosis in human T lymphoblastoid Jurkat leukemia cells and...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2002-11, Vol.59 (11), p.2004-2012
Hauptverfasser:	Fimognari, C, Nüsse, M, Berti, F, Iori, R, Cantelli-Forti, G, Hrelia, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticarcinogenic Agents - pharmacology Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein Cell cycle Cell Cycle - drug effects Chemotherapy Cyclin D2 Cyclin D3 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism Cyclins - genetics Cyclins - metabolism Humans Isothiocyanates Leukemia Lymphocytes Molecular biology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Sulfoxides T cell receptors T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - metabolism Thiocyanates - pharmacology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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