Muscle mass dynamics is independently associated with long-term liver-related mortality in patients with cirrhosis
Sarcopenia has a detrimental impact on the prognosis of individuals with liver cirrhosis, however, the clinical significance of alterations in muscle mass remains uncertain. This study aims to investigate the influence of loss of skeletal muscle mass (LSMM) on the prognostic outcomes among patients...
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| creator | Zheng, Jiarui Yang, Shuo Ren, Wenhui Zhong, Juan Liu, Xin Han, Rui Wei, Tingyang Tie, Changjie Yang, Yuteng Hong, Chengwu Feng, Bo Huang, Rui |
| description | Sarcopenia has a detrimental impact on the prognosis of individuals with liver cirrhosis, however, the clinical significance of alterations in muscle mass remains uncertain. This study aims to investigate the influence of loss of skeletal muscle mass (LSMM) on the prognostic outcomes among patients diagnosed with cirrhosis.
In this retrospective analysis, a total of 158 individuals with cirrhosis who visited our hospital during the period from January 2018 to August 2023 were included. Computed tomography was utilized to measure the cross-sectional area of the skeletal muscles at the level of the third lumbar vertebra. This measurement enabled the determination of the skeletal muscle index for the purpose of diagnosing sarcopenia. The annual relative change in skeletal muscle area (ΔSMA/y) was calculated for each patient, and LSMM was defined as ΔSMA/y |
| doi_str_mv | 10.1016/j.heliyon.2024.e35354 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11336566</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2405844024113850</els_id><sourcerecordid>3154165945</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-d78c3adbfd9160e1b31c6e7eda203686fdc6894c3f96cb58875f20a1ebe2858d3</originalsourceid><addsrcrecordid>eNqFkV9PHCEUxUnTphrrR9DMY19mheHPME_GmLaaaHzRZ8LAHZcNM6zAbjPfXnRXa59MCJCcew738kPohOAFwUScrRZL8G4O06LBDVsA5ZSzL-iwYZjXkjH89cP9AB2ntMIYEy5F19Lv6IB2pMUUy0MUbzfJeKhGnVJl50mPzqTKlTVZWEPZpuznqqjBOJ3BVn9dXlY-TI91hjhW3m0h1hH8qziGmLV3eS7-aq2zK_a0sxgX4zIkl36gb4P2CY735xF6-P3r_vKqvrn7c315cVMb2na5tq00VNt-sB0RGEhPiRHQgtUNpkKKwRohO2bo0AnTcylbPjRYE-ihkVxaeoTOd7nrTT-CNaWVqL1aRzfqOKugnfpfmdxSPYatIoRSwYUoCT_3CTE8bSBlNbpkwHs9QdgkRQlnRPCO8c9LccdFy5qWlFK-KzUxpBRheG-JYPWCV63UHq96wat2eIvv9OM87643mP8GhvKrWwdRJVMAGLAugsnKBvfJE88bHL1i</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3095674271</pqid></control><display><type>article</type><title>Muscle mass dynamics is independently associated with long-term liver-related mortality in patients with cirrhosis</title><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zheng, Jiarui ; Yang, Shuo ; Ren, Wenhui ; Zhong, Juan ; Liu, Xin ; Han, Rui ; Wei, Tingyang ; Tie, Changjie ; Yang, Yuteng ; Hong, Chengwu ; Feng, Bo ; Huang, Rui</creator><creatorcontrib>Zheng, Jiarui ; Yang, Shuo ; Ren, Wenhui ; Zhong, Juan ; Liu, Xin ; Han, Rui ; Wei, Tingyang ; Tie, Changjie ; Yang, Yuteng ; Hong, Chengwu ; Feng, Bo ; Huang, Rui</creatorcontrib><description>Sarcopenia has a detrimental impact on the prognosis of individuals with liver cirrhosis, however, the clinical significance of alterations in muscle mass remains uncertain. This study aims to investigate the influence of loss of skeletal muscle mass (LSMM) on the prognostic outcomes among patients diagnosed with cirrhosis.
In this retrospective analysis, a total of 158 individuals with cirrhosis who visited our hospital during the period from January 2018 to August 2023 were included. Computed tomography was utilized to measure the cross-sectional area of the skeletal muscles at the level of the third lumbar vertebra. This measurement enabled the determination of the skeletal muscle index for the purpose of diagnosing sarcopenia. The annual relative change in skeletal muscle area (ΔSMA/y) was calculated for each patient, and LSMM was defined as ΔSMA/y < 0. To assess the risk factors associated with liver-related mortality, a competing risk model was applied.
Of the 158 cirrhotic patients, 95 (60.1 %) patients were identified as LSMM. The median of ΔSMA/y% was −0.9 (interquartile range [IQR], −3.8, 1.6) in all patients. Chronic kidney disease (CKD) was confirmed as a risk factor of LSMM. During a median follow-up period of 68.1 (IQR, 43.5, 105.0) months, 57 patients (36.1 %) died due to the liver-related diseases. The competing risk model found that LSMM was significantly associated with liver-related mortality in cirrhotic patients (hazard ratio [HR], 1.86; 95 % CI, 1.01–3.44, p = 0.047). Cumulative survival was significantly higher in patients without LSMM than in those with LSMM (p = 0.004). Survival rates at 1-, 3-, and 5-years were 96.8 %, 81.0 %, and 65.1 %, respectively, in patients without LSMM, and 97.9 %, 80.0 %, and 56.8 %, respectively, in patients with LSMM.
The utilization of LSMM can be valuable in the prediction of liver-related mortality among individuals diagnosed with liver cirrhosis. Paying attention to the management of skeletal muscle might play a role in enhancing the prognosis of patients with cirrhosis.
This study provides an additional indicator—LSMM for clinicians to help predict the liver-related mortality in patients diagnosed with cirrhosis.</description><identifier>ISSN: 2405-8440</identifier><identifier>EISSN: 2405-8440</identifier><identifier>DOI: 10.1016/j.heliyon.2024.e35354</identifier><identifier>PMID: 39170308</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>computed tomography ; hazard ratio ; hospitals ; kidney diseases ; Liver cirrhosis ; Loss of skeletal muscle mass ; Mortality ; patients ; prediction ; prognosis ; retrospective studies ; risk assessment ; risk factors ; Sarcopenia ; skeletal muscle ; vertebrae</subject><ispartof>Heliyon, 2024-08, Vol.10 (15), p.e35354, Article e35354</ispartof><rights>2024 The Authors</rights><rights>2024 The Authors.</rights><rights>2024 The Authors 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c379t-d78c3adbfd9160e1b31c6e7eda203686fdc6894c3f96cb58875f20a1ebe2858d3</cites><orcidid>0000-0001-5561-8746</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11336566/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11336566/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39170308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Jiarui</creatorcontrib><creatorcontrib>Yang, Shuo</creatorcontrib><creatorcontrib>Ren, Wenhui</creatorcontrib><creatorcontrib>Zhong, Juan</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Han, Rui</creatorcontrib><creatorcontrib>Wei, Tingyang</creatorcontrib><creatorcontrib>Tie, Changjie</creatorcontrib><creatorcontrib>Yang, Yuteng</creatorcontrib><creatorcontrib>Hong, Chengwu</creatorcontrib><creatorcontrib>Feng, Bo</creatorcontrib><creatorcontrib>Huang, Rui</creatorcontrib><title>Muscle mass dynamics is independently associated with long-term liver-related mortality in patients with cirrhosis</title><title>Heliyon</title><addtitle>Heliyon</addtitle><description>Sarcopenia has a detrimental impact on the prognosis of individuals with liver cirrhosis, however, the clinical significance of alterations in muscle mass remains uncertain. This study aims to investigate the influence of loss of skeletal muscle mass (LSMM) on the prognostic outcomes among patients diagnosed with cirrhosis.
In this retrospective analysis, a total of 158 individuals with cirrhosis who visited our hospital during the period from January 2018 to August 2023 were included. Computed tomography was utilized to measure the cross-sectional area of the skeletal muscles at the level of the third lumbar vertebra. This measurement enabled the determination of the skeletal muscle index for the purpose of diagnosing sarcopenia. The annual relative change in skeletal muscle area (ΔSMA/y) was calculated for each patient, and LSMM was defined as ΔSMA/y < 0. To assess the risk factors associated with liver-related mortality, a competing risk model was applied.
Of the 158 cirrhotic patients, 95 (60.1 %) patients were identified as LSMM. The median of ΔSMA/y% was −0.9 (interquartile range [IQR], −3.8, 1.6) in all patients. Chronic kidney disease (CKD) was confirmed as a risk factor of LSMM. During a median follow-up period of 68.1 (IQR, 43.5, 105.0) months, 57 patients (36.1 %) died due to the liver-related diseases. The competing risk model found that LSMM was significantly associated with liver-related mortality in cirrhotic patients (hazard ratio [HR], 1.86; 95 % CI, 1.01–3.44, p = 0.047). Cumulative survival was significantly higher in patients without LSMM than in those with LSMM (p = 0.004). Survival rates at 1-, 3-, and 5-years were 96.8 %, 81.0 %, and 65.1 %, respectively, in patients without LSMM, and 97.9 %, 80.0 %, and 56.8 %, respectively, in patients with LSMM.
The utilization of LSMM can be valuable in the prediction of liver-related mortality among individuals diagnosed with liver cirrhosis. Paying attention to the management of skeletal muscle might play a role in enhancing the prognosis of patients with cirrhosis.
This study provides an additional indicator—LSMM for clinicians to help predict the liver-related mortality in patients diagnosed with cirrhosis.</description><subject>computed tomography</subject><subject>hazard ratio</subject><subject>hospitals</subject><subject>kidney diseases</subject><subject>Liver cirrhosis</subject><subject>Loss of skeletal muscle mass</subject><subject>Mortality</subject><subject>patients</subject><subject>prediction</subject><subject>prognosis</subject><subject>retrospective studies</subject><subject>risk assessment</subject><subject>risk factors</subject><subject>Sarcopenia</subject><subject>skeletal muscle</subject><subject>vertebrae</subject><issn>2405-8440</issn><issn>2405-8440</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkV9PHCEUxUnTphrrR9DMY19mheHPME_GmLaaaHzRZ8LAHZcNM6zAbjPfXnRXa59MCJCcew738kPohOAFwUScrRZL8G4O06LBDVsA5ZSzL-iwYZjXkjH89cP9AB2ntMIYEy5F19Lv6IB2pMUUy0MUbzfJeKhGnVJl50mPzqTKlTVZWEPZpuznqqjBOJ3BVn9dXlY-TI91hjhW3m0h1hH8qziGmLV3eS7-aq2zK_a0sxgX4zIkl36gb4P2CY735xF6-P3r_vKqvrn7c315cVMb2na5tq00VNt-sB0RGEhPiRHQgtUNpkKKwRohO2bo0AnTcylbPjRYE-ihkVxaeoTOd7nrTT-CNaWVqL1aRzfqOKugnfpfmdxSPYatIoRSwYUoCT_3CTE8bSBlNbpkwHs9QdgkRQlnRPCO8c9LccdFy5qWlFK-KzUxpBRheG-JYPWCV63UHq96wat2eIvv9OM87643mP8GhvKrWwdRJVMAGLAugsnKBvfJE88bHL1i</recordid><startdate>20240815</startdate><enddate>20240815</enddate><creator>Zheng, Jiarui</creator><creator>Yang, Shuo</creator><creator>Ren, Wenhui</creator><creator>Zhong, Juan</creator><creator>Liu, Xin</creator><creator>Han, Rui</creator><creator>Wei, Tingyang</creator><creator>Tie, Changjie</creator><creator>Yang, Yuteng</creator><creator>Hong, Chengwu</creator><creator>Feng, Bo</creator><creator>Huang, Rui</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5561-8746</orcidid></search><sort><creationdate>20240815</creationdate><title>Muscle mass dynamics is independently associated with long-term liver-related mortality in patients with cirrhosis</title><author>Zheng, Jiarui ; Yang, Shuo ; Ren, Wenhui ; Zhong, Juan ; Liu, Xin ; Han, Rui ; Wei, Tingyang ; Tie, Changjie ; Yang, Yuteng ; Hong, Chengwu ; Feng, Bo ; Huang, Rui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-d78c3adbfd9160e1b31c6e7eda203686fdc6894c3f96cb58875f20a1ebe2858d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>computed tomography</topic><topic>hazard ratio</topic><topic>hospitals</topic><topic>kidney diseases</topic><topic>Liver cirrhosis</topic><topic>Loss of skeletal muscle mass</topic><topic>Mortality</topic><topic>patients</topic><topic>prediction</topic><topic>prognosis</topic><topic>retrospective studies</topic><topic>risk assessment</topic><topic>risk factors</topic><topic>Sarcopenia</topic><topic>skeletal muscle</topic><topic>vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Jiarui</creatorcontrib><creatorcontrib>Yang, Shuo</creatorcontrib><creatorcontrib>Ren, Wenhui</creatorcontrib><creatorcontrib>Zhong, Juan</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Han, Rui</creatorcontrib><creatorcontrib>Wei, Tingyang</creatorcontrib><creatorcontrib>Tie, Changjie</creatorcontrib><creatorcontrib>Yang, Yuteng</creatorcontrib><creatorcontrib>Hong, Chengwu</creatorcontrib><creatorcontrib>Feng, Bo</creatorcontrib><creatorcontrib>Huang, Rui</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Heliyon</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Jiarui</au><au>Yang, Shuo</au><au>Ren, Wenhui</au><au>Zhong, Juan</au><au>Liu, Xin</au><au>Han, Rui</au><au>Wei, Tingyang</au><au>Tie, Changjie</au><au>Yang, Yuteng</au><au>Hong, Chengwu</au><au>Feng, Bo</au><au>Huang, Rui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Muscle mass dynamics is independently associated with long-term liver-related mortality in patients with cirrhosis</atitle><jtitle>Heliyon</jtitle><addtitle>Heliyon</addtitle><date>2024-08-15</date><risdate>2024</risdate><volume>10</volume><issue>15</issue><spage>e35354</spage><pages>e35354-</pages><artnum>e35354</artnum><issn>2405-8440</issn><eissn>2405-8440</eissn><abstract>Sarcopenia has a detrimental impact on the prognosis of individuals with liver cirrhosis, however, the clinical significance of alterations in muscle mass remains uncertain. This study aims to investigate the influence of loss of skeletal muscle mass (LSMM) on the prognostic outcomes among patients diagnosed with cirrhosis.
In this retrospective analysis, a total of 158 individuals with cirrhosis who visited our hospital during the period from January 2018 to August 2023 were included. Computed tomography was utilized to measure the cross-sectional area of the skeletal muscles at the level of the third lumbar vertebra. This measurement enabled the determination of the skeletal muscle index for the purpose of diagnosing sarcopenia. The annual relative change in skeletal muscle area (ΔSMA/y) was calculated for each patient, and LSMM was defined as ΔSMA/y < 0. To assess the risk factors associated with liver-related mortality, a competing risk model was applied.
Of the 158 cirrhotic patients, 95 (60.1 %) patients were identified as LSMM. The median of ΔSMA/y% was −0.9 (interquartile range [IQR], −3.8, 1.6) in all patients. Chronic kidney disease (CKD) was confirmed as a risk factor of LSMM. During a median follow-up period of 68.1 (IQR, 43.5, 105.0) months, 57 patients (36.1 %) died due to the liver-related diseases. The competing risk model found that LSMM was significantly associated with liver-related mortality in cirrhotic patients (hazard ratio [HR], 1.86; 95 % CI, 1.01–3.44, p = 0.047). Cumulative survival was significantly higher in patients without LSMM than in those with LSMM (p = 0.004). Survival rates at 1-, 3-, and 5-years were 96.8 %, 81.0 %, and 65.1 %, respectively, in patients without LSMM, and 97.9 %, 80.0 %, and 56.8 %, respectively, in patients with LSMM.
The utilization of LSMM can be valuable in the prediction of liver-related mortality among individuals diagnosed with liver cirrhosis. Paying attention to the management of skeletal muscle might play a role in enhancing the prognosis of patients with cirrhosis.
This study provides an additional indicator—LSMM for clinicians to help predict the liver-related mortality in patients diagnosed with cirrhosis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39170308</pmid><doi>10.1016/j.heliyon.2024.e35354</doi><orcidid>https://orcid.org/0000-0001-5561-8746</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | computed tomography hazard ratio hospitals kidney diseases Liver cirrhosis Loss of skeletal muscle mass Mortality patients prediction prognosis retrospective studies risk assessment risk factors Sarcopenia skeletal muscle vertebrae |
| title | Muscle mass dynamics is independently associated with long-term liver-related mortality in patients with cirrhosis |
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