Amyloid β accelerates age-related proteome-wide protein insolubility

Loss of proteostasis is a highly conserved feature of aging across model organisms and results in the accumulation of insoluble protein aggregates. Protein insolubility is also a unifying feature of major age-related neurodegenerative diseases, including Alzheimer's Disease (AD), in which hundr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	GeroScience 2024-05, Vol.46 (5), p.4585-4602
Hauptverfasser:	Anderton, Edward, Chamoli, Manish, Bhaumik, Dipa, King, Christina D., Xie, Xueshu, Foulger, Anna, Andersen, Julie K., Schilling, Birgit, Lithgow, Gordon J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - genetics Aging - metabolism Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Animals Biomedical and Life Sciences Caenorhabditis elegans - metabolism Cell Biology Clinical trials Dementia disorders Disease Models, Animal Genome-wide association studies Geriatrics/Gerontology Humans Life Sciences Life span Molecular Medicine Neurodegenerative diseases Original Original Article Proteins Proteome - metabolism Proteomes Proteomics Proteostasis Senile plaques Solubility Toxicity β-Amyloid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!