Risk of glaucoma to subsequent dementia or cognitive impairment: a systematic review and meta-analysis
Background Substantial evidence supports that glaucoma and dementia share pathological mechanisms and pathogenic risk factors. However, the association between glaucoma, cognitive decline and dementia has yet to be elucidated. Objective This study was aimed to assess whether glaucoma increase the ri...
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| Veröffentlicht in: | Aging clinical and experimental research 2024-08, Vol.36 (1), p.172 |
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| creator | Wang, Xiaoran Chen, Wenjing Zhao, Wenxia Miao, Mingsan |
| description | Background
Substantial evidence supports that glaucoma and dementia share pathological mechanisms and pathogenic risk factors. However, the association between glaucoma, cognitive decline and dementia has yet to be elucidated.
Objective
This study was aimed to assess whether glaucoma increase the risk of dementia or cognitive impairment.
Methods
PubMed, Cochrane Library, Web of Science, and EMBASE databases for cohort or case-control studies were searched from inception to March 10, 2024. The Newcastle-Ottawa Quality Assessment Scale (NOS) was used to the risk of bias. Heterogeneity was rigorously evaluated using the
I
2
test, while publication bias was assessed by visual inspection of the funnel plot and by Egger’ s regression asymmetry test. Subgroup analyses were applied to determine the sources of heterogeneity.
Results
Twenty-seven studies covering 9,061,675 individuals were included. Pooled analyses indicated that glaucoma increased the risk of all-cause dementia, Alzheimer’s disease, vascular dementia, and cognitive impairment. Subgroup analysis showed that the prevalence of dementia was 2.90 (95% CI: 1.45–5.77) in age ≥ 65 years and 2.07 (95% CI: 1.18–3.62) in age |
| doi_str_mv | 10.1007/s40520-024-02811-w |
| format | Article |
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Substantial evidence supports that glaucoma and dementia share pathological mechanisms and pathogenic risk factors. However, the association between glaucoma, cognitive decline and dementia has yet to be elucidated.
Objective
This study was aimed to assess whether glaucoma increase the risk of dementia or cognitive impairment.
Methods
PubMed, Cochrane Library, Web of Science, and EMBASE databases for cohort or case-control studies were searched from inception to March 10, 2024. The Newcastle-Ottawa Quality Assessment Scale (NOS) was used to the risk of bias. Heterogeneity was rigorously evaluated using the
I
2
test, while publication bias was assessed by visual inspection of the funnel plot and by Egger’ s regression asymmetry test. Subgroup analyses were applied to determine the sources of heterogeneity.
Results
Twenty-seven studies covering 9,061,675 individuals were included. Pooled analyses indicated that glaucoma increased the risk of all-cause dementia, Alzheimer’s disease, vascular dementia, and cognitive impairment. Subgroup analysis showed that the prevalence of dementia was 2.90 (95% CI: 1.45–5.77) in age ≥ 65 years and 2.07 (95% CI: 1.18–3.62) in age<65 years; the incidence rates in female glaucoma patients was 1.46 (95% CI: 1.06-2.00), respectively, which was no statistical significance in male patients. Among glaucoma types, POAG was more likely to develop dementia and cognitive impairment. There were also differences in regional distribution, with the highest prevalence in the Asia region, while glaucoma was not associated with dementia in Europe and North America regions.
Conclusion
Glaucoma increased the risk of subsequent cognitive impairment and dementia. The type of glaucoma, gender, age, and region composition of the study population may significantly affect the relationship between glaucoma and dementia.</description><identifier>ISSN: 1594-0667</identifier><identifier>ISSN: 1720-8319</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-024-02811-w</identifier><identifier>PMID: 39162899</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Cognitive ability ; Cognitive Dysfunction - epidemiology ; Dementia ; Dementia - epidemiology ; Geriatrics/Gerontology ; Glaucoma ; Glaucoma - epidemiology ; Humans ; Medicine ; Medicine & Public Health ; Risk Factors ; Systematic Review</subject><ispartof>Aging clinical and experimental research, 2024-08, Vol.36 (1), p.172</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p313t-88f4fcd9c070f7cdcb2d91992e1d7efc150c5d4c29019fc139c2cae0ea168cdb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-024-02811-w$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-024-02811-w$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39162899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xiaoran</creatorcontrib><creatorcontrib>Chen, Wenjing</creatorcontrib><creatorcontrib>Zhao, Wenxia</creatorcontrib><creatorcontrib>Miao, Mingsan</creatorcontrib><title>Risk of glaucoma to subsequent dementia or cognitive impairment: a systematic review and meta-analysis</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background
Substantial evidence supports that glaucoma and dementia share pathological mechanisms and pathogenic risk factors. However, the association between glaucoma, cognitive decline and dementia has yet to be elucidated.
Objective
This study was aimed to assess whether glaucoma increase the risk of dementia or cognitive impairment.
Methods
PubMed, Cochrane Library, Web of Science, and EMBASE databases for cohort or case-control studies were searched from inception to March 10, 2024. The Newcastle-Ottawa Quality Assessment Scale (NOS) was used to the risk of bias. Heterogeneity was rigorously evaluated using the
I
2
test, while publication bias was assessed by visual inspection of the funnel plot and by Egger’ s regression asymmetry test. Subgroup analyses were applied to determine the sources of heterogeneity.
Results
Twenty-seven studies covering 9,061,675 individuals were included. Pooled analyses indicated that glaucoma increased the risk of all-cause dementia, Alzheimer’s disease, vascular dementia, and cognitive impairment. Subgroup analysis showed that the prevalence of dementia was 2.90 (95% CI: 1.45–5.77) in age ≥ 65 years and 2.07 (95% CI: 1.18–3.62) in age<65 years; the incidence rates in female glaucoma patients was 1.46 (95% CI: 1.06-2.00), respectively, which was no statistical significance in male patients. Among glaucoma types, POAG was more likely to develop dementia and cognitive impairment. There were also differences in regional distribution, with the highest prevalence in the Asia region, while glaucoma was not associated with dementia in Europe and North America regions.
Conclusion
Glaucoma increased the risk of subsequent cognitive impairment and dementia. The type of glaucoma, gender, age, and region composition of the study population may significantly affect the relationship between glaucoma and dementia.</description><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Dementia</subject><subject>Dementia - epidemiology</subject><subject>Geriatrics/Gerontology</subject><subject>Glaucoma</subject><subject>Glaucoma - epidemiology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Risk Factors</subject><subject>Systematic Review</subject><issn>1594-0667</issn><issn>1720-8319</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNpdUU1P3DAQtSoQ0C1_oAdkiUsvaT12Nol7QRXqBxISEoKzNWtPtqZJvLWTXe2_x9ulhXLwjMfv6el5HmPvQXwEIepPqRRzKQohy3wagGLzhp1AnZ8aBfog3-c6Q1VVH7O3KT0IUUIGjtix0lDJRusT1t769IuHli87nGzokY-Bp2mR6PdEw8gd9bl55CFyG5aDH_2auO9X6OMO-cyRp20aqcfRWx5p7WnDcXC8pxELHLDbJp_escMWu0SnT33G7r99vbv8UVzffL-6_HJdrBSosWiatmyt01bUoq2tswvpNGgtCVxNrYW5sHNXWqkF6DwqbaVFEoRQNdYt1Ixd7HVX06InZ7PDiJ1ZRd9j3JqA3vyPDP6nWYa1AVAqb6vOCh-eFGLIK0ij6X2y1HU4UJiSUUKXjayaakc9f0V9CFPMP96ztJIylxk7e2npn5e_GWSC2hNShoYlxWcZEGaXtNknbXLS5k_SZqMeAVhgnKU</recordid><startdate>20240820</startdate><enddate>20240820</enddate><creator>Wang, Xiaoran</creator><creator>Chen, Wenjing</creator><creator>Zhao, Wenxia</creator><creator>Miao, Mingsan</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240820</creationdate><title>Risk of glaucoma to subsequent dementia or cognitive impairment: a systematic review and meta-analysis</title><author>Wang, Xiaoran ; Chen, Wenjing ; Zhao, Wenxia ; Miao, Mingsan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p313t-88f4fcd9c070f7cdcb2d91992e1d7efc150c5d4c29019fc139c2cae0ea168cdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Dementia</topic><topic>Dementia - epidemiology</topic><topic>Geriatrics/Gerontology</topic><topic>Glaucoma</topic><topic>Glaucoma - epidemiology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Risk Factors</topic><topic>Systematic Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xiaoran</creatorcontrib><creatorcontrib>Chen, Wenjing</creatorcontrib><creatorcontrib>Zhao, Wenxia</creatorcontrib><creatorcontrib>Miao, Mingsan</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiaoran</au><au>Chen, Wenjing</au><au>Zhao, Wenxia</au><au>Miao, Mingsan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of glaucoma to subsequent dementia or cognitive impairment: a systematic review and meta-analysis</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2024-08-20</date><risdate>2024</risdate><volume>36</volume><issue>1</issue><spage>172</spage><pages>172-</pages><issn>1594-0667</issn><issn>1720-8319</issn><eissn>1720-8319</eissn><abstract>Background
Substantial evidence supports that glaucoma and dementia share pathological mechanisms and pathogenic risk factors. However, the association between glaucoma, cognitive decline and dementia has yet to be elucidated.
Objective
This study was aimed to assess whether glaucoma increase the risk of dementia or cognitive impairment.
Methods
PubMed, Cochrane Library, Web of Science, and EMBASE databases for cohort or case-control studies were searched from inception to March 10, 2024. The Newcastle-Ottawa Quality Assessment Scale (NOS) was used to the risk of bias. Heterogeneity was rigorously evaluated using the
I
2
test, while publication bias was assessed by visual inspection of the funnel plot and by Egger’ s regression asymmetry test. Subgroup analyses were applied to determine the sources of heterogeneity.
Results
Twenty-seven studies covering 9,061,675 individuals were included. Pooled analyses indicated that glaucoma increased the risk of all-cause dementia, Alzheimer’s disease, vascular dementia, and cognitive impairment. Subgroup analysis showed that the prevalence of dementia was 2.90 (95% CI: 1.45–5.77) in age ≥ 65 years and 2.07 (95% CI: 1.18–3.62) in age<65 years; the incidence rates in female glaucoma patients was 1.46 (95% CI: 1.06-2.00), respectively, which was no statistical significance in male patients. Among glaucoma types, POAG was more likely to develop dementia and cognitive impairment. There were also differences in regional distribution, with the highest prevalence in the Asia region, while glaucoma was not associated with dementia in Europe and North America regions.
Conclusion
Glaucoma increased the risk of subsequent cognitive impairment and dementia. The type of glaucoma, gender, age, and region composition of the study population may significantly affect the relationship between glaucoma and dementia.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>39162899</pmid><doi>10.1007/s40520-024-02811-w</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Aging clinical and experimental research, 2024-08, Vol.36 (1), p.172 |
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| source | MEDLINE; SpringerNature Journals; Alma/SFX Local Collection |
| subjects | Cognitive ability Cognitive Dysfunction - epidemiology Dementia Dementia - epidemiology Geriatrics/Gerontology Glaucoma Glaucoma - epidemiology Humans Medicine Medicine & Public Health Risk Factors Systematic Review |
| title | Risk of glaucoma to subsequent dementia or cognitive impairment: a systematic review and meta-analysis |
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