The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth
Sex pheromones play crucial role in mating behavior of moths, involving intricate recognition mechanisms. While insect chemical biology has extensively studied type I pheromones, type II pheromones remain largely unexplored. This study focused on Helicoverpa armigera , a representative species of no...
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| creator | Wang, Chenrui Cao, Song Shi, Chen Guo, Mengbo Sun, Dongdong Liu, Zheyi Xiu, Peng Wang, Yong Wang, Guirong Liu, Yang |
| description | Sex pheromones play crucial role in mating behavior of moths, involving intricate recognition mechanisms. While insect chemical biology has extensively studied type I pheromones, type II pheromones remain largely unexplored. This study focused on
Helicoverpa armigera
, a representative species of noctuid moth, aiming to reassess its sex pheromone composition. Our research unveiled two previously unidentified candidate type II sex pheromones—3Z,6Z,9Z-21:H and 3Z,6Z,9Z-23:H—in
H. armigera
. Furthermore, we identified HarmOR11 as an orphan pheromone receptor of 3Z,6Z,9Z-21:H. Through AlphaFold2 structural prediction, molecular docking, and molecular dynamics simulations, we elucidated the structural basis and key residues governing the sensory nuances of both type I and type II pheromone receptors, particularly HarmOR11 and HarmOR13. This study not only reveals the presence and recognition of candidate type II pheromones in a noctuid moth, but also establishes a comprehensive structural framework for PRs, contributing to the understanding of connections between evolutionary adaptations and the emergence of new pheromone types. |
| doi_str_mv | 10.1007/s00018-024-05303-2 |
| format | Article |
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Helicoverpa armigera
, a representative species of noctuid moth, aiming to reassess its sex pheromone composition. Our research unveiled two previously unidentified candidate type II sex pheromones—3Z,6Z,9Z-21:H and 3Z,6Z,9Z-23:H—in
H. armigera
. Furthermore, we identified HarmOR11 as an orphan pheromone receptor of 3Z,6Z,9Z-21:H. Through AlphaFold2 structural prediction, molecular docking, and molecular dynamics simulations, we elucidated the structural basis and key residues governing the sensory nuances of both type I and type II pheromone receptors, particularly HarmOR11 and HarmOR13. This study not only reveals the presence and recognition of candidate type II pheromones in a noctuid moth, but also establishes a comprehensive structural framework for PRs, contributing to the understanding of connections between evolutionary adaptations and the emergence of new pheromone types.</description><identifier>ISSN: 1420-682X</identifier><identifier>ISSN: 1420-9071</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-024-05303-2</identifier><identifier>PMID: 38878072</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Butterflies & moths ; Cell Biology ; Ecological adaptation ; Female ; Gas Chromatography-Mass Spectrometry ; Helicoverpa armigera ; Helicoverpa armigera - genetics ; Helicoverpa armigera - physiology ; Insects ; Life Sciences ; Male ; Mating behavior ; Models, Molecular ; Molecular docking ; Molecular dynamics ; moths ; Mutation ; Oocytes ; Original ; Original Article ; Pheromone receptors ; Pheromones ; Phylogeny ; prediction ; Receptors ; Receptors, Pheromone - chemistry ; Receptors, Pheromone - classification ; Receptors, Pheromone - genetics ; Receptors, Pheromone - physiology ; Recognition ; Sex ; Sex Attractants - physiology ; Sex pheromone ; sex pheromones ; species ; Xenopus laevis</subject><ispartof>Cellular and molecular life sciences : CMLS, 2024-12, Vol.81 (1), p.259-259</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p416t-514bec85c45ab44b9d290f164d30eb0ddc93784ddc8f54e9ac07d1b28df0753b3</cites><orcidid>0000-0002-3424-7111</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335300/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335300/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,41103,41471,42172,42540,51302,51559,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38878072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Chenrui</creatorcontrib><creatorcontrib>Cao, Song</creatorcontrib><creatorcontrib>Shi, Chen</creatorcontrib><creatorcontrib>Guo, Mengbo</creatorcontrib><creatorcontrib>Sun, Dongdong</creatorcontrib><creatorcontrib>Liu, Zheyi</creatorcontrib><creatorcontrib>Xiu, Peng</creatorcontrib><creatorcontrib>Wang, Yong</creatorcontrib><creatorcontrib>Wang, Guirong</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><title>The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Sex pheromones play crucial role in mating behavior of moths, involving intricate recognition mechanisms. While insect chemical biology has extensively studied type I pheromones, type II pheromones remain largely unexplored. This study focused on
Helicoverpa armigera
, a representative species of noctuid moth, aiming to reassess its sex pheromone composition. Our research unveiled two previously unidentified candidate type II sex pheromones—3Z,6Z,9Z-21:H and 3Z,6Z,9Z-23:H—in
H. armigera
. Furthermore, we identified HarmOR11 as an orphan pheromone receptor of 3Z,6Z,9Z-21:H. Through AlphaFold2 structural prediction, molecular docking, and molecular dynamics simulations, we elucidated the structural basis and key residues governing the sensory nuances of both type I and type II pheromone receptors, particularly HarmOR11 and HarmOR13. This study not only reveals the presence and recognition of candidate type II pheromones in a noctuid moth, but also establishes a comprehensive structural framework for PRs, contributing to the understanding of connections between evolutionary adaptations and the emergence of new pheromone types.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Butterflies & moths</subject><subject>Cell Biology</subject><subject>Ecological adaptation</subject><subject>Female</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Helicoverpa armigera</subject><subject>Helicoverpa armigera - genetics</subject><subject>Helicoverpa armigera - physiology</subject><subject>Insects</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mating behavior</subject><subject>Models, Molecular</subject><subject>Molecular docking</subject><subject>Molecular dynamics</subject><subject>moths</subject><subject>Mutation</subject><subject>Oocytes</subject><subject>Original</subject><subject>Original Article</subject><subject>Pheromone receptors</subject><subject>Pheromones</subject><subject>Phylogeny</subject><subject>prediction</subject><subject>Receptors</subject><subject>Receptors, Pheromone - chemistry</subject><subject>Receptors, Pheromone - classification</subject><subject>Receptors, Pheromone - genetics</subject><subject>Receptors, Pheromone - physiology</subject><subject>Recognition</subject><subject>Sex</subject><subject>Sex Attractants - physiology</subject><subject>Sex pheromone</subject><subject>sex pheromones</subject><subject>species</subject><subject>Xenopus laevis</subject><issn>1420-682X</issn><issn>1420-9071</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNqFks1u1TAQhSMEoqXwAiyQJTZsAuO_xFkhVFFAqsSmSOysxJk0rhI72M4tlyfp4-L7AwU2bDyWzuczR-MpiucUXlOA-k0EAKpKYKIEyYGX7EFxSgWDsoGaPjzeK8W-nhRPYrzJtFSselyccKVqBTU7Le6uRiTOb3Aiw-pMst4RP5A2n2EZc1lGDH72DklAg0vyIV822E6RpPw0oos-bElc0Nh2sj_anUXceaRbTxaf0KUskN7GZHMDkrYL7vWI3-_dI7Eu5zBptT2ZfRqfFo-G3ASfHetZ8eXi_dX5x_Ly84dP5-8uy0XQKpWSig6NkkbIthOia3rWwEAr0XPADvreNLxWIlc1SIFNa6DuacdUP0AtecfPircH32XtZuxNjhvaSS_Bzm3Yat9a_bfi7Kiv_UZTynmeOmSHV0eH4L-tGJOebTQ4Ta1Dv0bNqeRV1dQV-z8KlaollY3I6Mt_0Bu_BpdHsaeEYorzTL34M_3v2L8-OAP8AMQsuWsM9zYU9G6N9GGNdF4jvV8jzfhPd-W8xA</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>Wang, Chenrui</creator><creator>Cao, Song</creator><creator>Shi, Chen</creator><creator>Guo, Mengbo</creator><creator>Sun, Dongdong</creator><creator>Liu, Zheyi</creator><creator>Xiu, Peng</creator><creator>Wang, Yong</creator><creator>Wang, Guirong</creator><creator>Liu, Yang</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3424-7111</orcidid></search><sort><creationdate>20241201</creationdate><title>The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth</title><author>Wang, Chenrui ; 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Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>81</volume><issue>1</issue><spage>259</spage><epage>259</epage><pages>259-259</pages><issn>1420-682X</issn><issn>1420-9071</issn><eissn>1420-9071</eissn><abstract>Sex pheromones play crucial role in mating behavior of moths, involving intricate recognition mechanisms. While insect chemical biology has extensively studied type I pheromones, type II pheromones remain largely unexplored. This study focused on
Helicoverpa armigera
, a representative species of noctuid moth, aiming to reassess its sex pheromone composition. Our research unveiled two previously unidentified candidate type II sex pheromones—3Z,6Z,9Z-21:H and 3Z,6Z,9Z-23:H—in
H. armigera
. Furthermore, we identified HarmOR11 as an orphan pheromone receptor of 3Z,6Z,9Z-21:H. Through AlphaFold2 structural prediction, molecular docking, and molecular dynamics simulations, we elucidated the structural basis and key residues governing the sensory nuances of both type I and type II pheromone receptors, particularly HarmOR11 and HarmOR13. This study not only reveals the presence and recognition of candidate type II pheromones in a noctuid moth, but also establishes a comprehensive structural framework for PRs, contributing to the understanding of connections between evolutionary adaptations and the emergence of new pheromone types.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>38878072</pmid><doi>10.1007/s00018-024-05303-2</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3424-7111</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedicine Butterflies & moths Cell Biology Ecological adaptation Female Gas Chromatography-Mass Spectrometry Helicoverpa armigera Helicoverpa armigera - genetics Helicoverpa armigera - physiology Insects Life Sciences Male Mating behavior Models, Molecular Molecular docking Molecular dynamics moths Mutation Oocytes Original Original Article Pheromone receptors Pheromones Phylogeny prediction Receptors Receptors, Pheromone - chemistry Receptors, Pheromone - classification Receptors, Pheromone - genetics Receptors, Pheromone - physiology Recognition Sex Sex Attractants - physiology Sex pheromone sex pheromones species Xenopus laevis |
| title | The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth |
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