Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer

Cisplatin resistance is a major challenge for systemic therapy against advanced bladder cancer (BC). Little information is available on the regulation of cisplatin resistance and the underlying mechanisms require elucidation. Here, we detected that downregulation of the tumor suppressor, PPP2R2B (a...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2024-12, Vol.81 (1), p.292-292, Article 292
Hauptverfasser:	Huang, Gaowei, Liu, Jinwen, Yu, Anze, Luo, Chenggong, Zhu, Jiangquan, Wang, Yinghan, Dai, Ziran, Zhang, Lizhen, Feng, Zihao, Lu, Jun, Dong, Zhong, Luo, Junhang, Chen, Wei, Chen, Zhenhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Biochemistry Biomarkers Biomedical and Life Sciences Biomedicine Bladder Bladder cancer Cancer Cell Biology Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Nucleus - metabolism Cell proliferation Cell Proliferation - drug effects Chemotherapy Cisplatin Cisplatin - pharmacology Cytokines - metabolism DNA repair Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics drug therapy Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Histones Humans Life Sciences Lysine Methylation Mice Mice, Inbred BALB C Mice, Nude Nerve Tissue Proteins Nuclear transport nucleocytoplasmic transport Original Original Article Protein phosphatase Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism serine threonine Translocation Tumor suppressor genes Ubiquitins - genetics Ubiquitins - metabolism urinary bladder neoplasms Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology
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