Classification of prostaglandin receptors based on coupling to signal transduction systems

A wide spectrum of prostaglandins (PG) stimulate both the production of cyclic AMP and an increase in free cytosolic Ca2+ concentration [( Ca2+]i) in the osteogenic osteosarcoma cell line, UMR-106-01, which has characteristics compatible with osteoblasts. Using PG-stimulated determinations of the se...

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Veröffentlicht in:	Biochemical journal 1989-11, Vol.263 (3), p.769-774
Hauptverfasser:	Muallem, S, Merritt, B S, Green, J, Kleeman, C R, Yamaguchi, D T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - physiology Calcium - metabolism Cyclic AMP - metabolism Humans In Vitro Techniques Ionomycin - pharmacology Osteosarcoma Parathyroid Hormone - pharmacology Prostaglandins - pharmacology Receptors, Prostaglandin - classification Receptors, Prostaglandin - physiology Signal Transduction Tumor Cells, Cultured Type C Phospholipases - physiology
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