Contribution of Noncovalent Recognition and Reactivity to the Optimization of Covalent Inhibitors: A Case Study on KRasG12C

Covalent drugs might bear electrophiles to chemically modify their targets and have the potential to target previously undruggable proteins with high potency. Covalent binding of drug-size molecules includes a noncovalent recognition provided by secondary interactions and a chemical reaction leading...

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Veröffentlicht in:	ACS chemical biology 2024-08, Vol.19 (8), p.1743-1756
Hauptverfasser:	Péczka, Nikolett, Ranđelović, Ivan, Orgován, Zoltán, Csorba, Noémi, Egyed, Attila, Petri, László, Ábrányi-Balogh, Péter, Gadanecz, Márton, Perczel, András, Tóvári, József, Schlosser, Gitta, Takács, Tamás, Mihalovits, Levente M., Ferenczy, György G., Buday, László, Keserű, György M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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