Cell-free DNA for the detection of kidney allograft rejection

Donor-derived cell-free DNA (dd-cfDNA) is an emerging noninvasive biomarker that has the potential to detect allograft injury. The capacity of dd-cfDNA to detect kidney allograft rejection and its added clinical value beyond standard of care patient monitoring is unclear. We enrolled 2,882 kidney al...

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Veröffentlicht in:	Nature medicine 2024-08, Vol.30 (8), p.2320-2327
Hauptverfasser:	Aubert, Olivier, Ursule-Dufait, Cindy, Brousse, Romain, Gueguen, Juliette, Racapé, Maud, Raynaud, Marc, Van Loon, Elisabet, Pagliazzi, Angelica, Huang, Edmund, Jordan, Stanley C., Chavin, Kenneth D., Gupta, Gaurav, Kumar, Dhiren, Alhamad, Tarek, Anand, Sanjiv, Sanchez-Garcia, Jorge, Abdalla, Basmah A., Hogan, Julien, Garro, Rouba, Dadhania, Darshana M., Jain, Pranjal, Mandelbrot, Didier A., Naesens, Maarten, Dandamudi, Raja, Dharnidharka, Vikas R., Anglicheau, Dany, Lefaucheur, Carmen, Loupy, Alexandre
Format:	Artikel
Sprache:	eng
Schlagworte:	692/499 692/53/2421 Adult Aged Allografts Allografts - immunology Biomarkers Biomarkers - blood Biomedical and Life Sciences Biomedicine Cancer Research Cell-Free Nucleic Acids - blood Cell-Free Nucleic Acids - genetics Confidence intervals Deoxyribonucleic acid DNA Female Graft rejection Graft Rejection - diagnosis Graft Rejection - genetics Graft Rejection - immunology Humans Infectious Diseases Injury analysis Kidney transplantation Kidney Transplantation - adverse effects Kidneys Lymphocytes Lymphocytes T Male Metabolic Diseases Middle Aged Molecular Medicine Monitoring Neurosciences Observational studies Patients Population studies Prediction models Rejection Standard of care Tissue Donors Transplantation Transplantation, Homologous
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Zusammenfassung:	Donor-derived cell-free DNA (dd-cfDNA) is an emerging noninvasive biomarker that has the potential to detect allograft injury. The capacity of dd-cfDNA to detect kidney allograft rejection and its added clinical value beyond standard of care patient monitoring is unclear. We enrolled 2,882 kidney allograft recipients from 14 transplantation centers in Europe and the United States in an observational population-based study. The primary analysis included 1,134 patients. Donor-derived cell-free DNA levels strongly correlated with allograft rejection, including antibody-mediated rejection ( P
ISSN:	1078-8956 1546-170X 1546-170X
DOI:	10.1038/s41591-024-03087-3