Value of [ 18 F]FDG PET/CT parameters of the primary tumor in assessing overall survival in NSCLC patients with cN1-cN3 lymph nodes involvement

The aim of this retrospective study was to assess the value of F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ([ F]FDG PET/CT parameters in cN1-cN3 non-small cell lung cancer (NSCLC) patients. 59 consecutive patients (35 M, 24 F) with NSCLC who underwent pretreatment [ F]FDG PET/CT were enrolled to this study. Several primary tumor PET parameters, including the maximum and mean standardized uptake value (SUV and SUV , the metabolic active tumor volume (MTV) and the total lesion glycolysis (TLG = MTVxSUV ), were extracted and analysed. Overall survival was defined as time from primary diagnosis to death or the last info. In the whole analysed group 44 patients underwent curative treatment, while 15, because of the severity of the disease, were classified for palliative treatment. Univariate Cox analysis of clinical and metric PET parameters revealed that MTV was a significant prognostic factor for OS (p = 0.024), while TLG and curative treatment showed a trend for significance (p < 0.1). In multivariate Cox regression (MTV and curative treatment) MTV remained a significant factor (p = 0.047). Metabolic tumor volume of the primary tumor was the only independent prognostic factor for cN1-cN3 NSCLC patients.