Human mitochondrial carriers of the SLC25 family function as monomers exchanging substrates with a ping-pong kinetic mechanism

Members of the SLC25 mitochondrial carrier family link cytosolic and mitochondrial metabolism and support cellular maintenance and growth by transporting compounds across the mitochondrial inner membrane. Their monomeric or dimeric state and kinetic mechanism have been a matter of long-standing deba...

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Veröffentlicht in:	The EMBO journal 2024-08, Vol.43 (16), p.3450-3465
Hauptverfasser:	Cimadamore-Werthein, Camila, King, Martin S, Lacabanne, Denis, Pyrihová, Eva, Jaiquel Baron, Stephany, Kunji, Edmund RS
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Amino Acid Transport Systems, Acidic - genetics Amino Acid Transport Systems, Acidic - metabolism Anion Transport Proteins - chemistry Anion Transport Proteins - genetics Anion Transport Proteins - metabolism Antiporters - chemistry Antiporters - genetics Antiporters - metabolism Biological Transport Biomedical and Life Sciences Carrier Proteins Dicarboxylic Acid Transporters - genetics Dicarboxylic Acid Transporters - metabolism EMBO20 EMBO57 Humans Kinetics Life Sciences Membrane Transport Proteins Mitochondria - genetics Mitochondria - metabolism Mitochondrial ADP, ATP Translocases - genetics Mitochondrial ADP, ATP Translocases - metabolism Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Organic Anion Transporters - chemistry Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Protein Multimerization
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