Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity

The protein phosphatase inhibitor okadaic acid suppressed autophagy completely in isolated rat hepatocytes, as measured by the sequestration of electroinjected [3H]raffinose into sedimentable autophagic vacuoles. Okadaic acid was effectively antagonized by the general protein kinase inhibitors K-252...

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Veröffentlicht in:	Biochemical journal 1992-06, Vol.284 ( Pt 3) (3), p.633-636
Hauptverfasser:	Holen, I, Gordon, P B, Seglen, P O
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives Alkaloids - pharmacology Animals Autophagy - drug effects Calcium-Calmodulin-Dependent Protein Kinases Calmodulin - antagonists & inhibitors Carbazoles - pharmacology Cells, Cultured cytoskeleton Cytoskeleton - drug effects Cytoskeleton - ultrastructure effects on Ethers, Cyclic - pharmacology hepatocytes Indole Alkaloids Indoles Isoquinolines - pharmacology Kinetics liver Liver - drug effects Liver - physiology Liver - ultrastructure Male Okadaic Acid Phosphoprotein Phosphatases - antagonists & inhibitors Piperazines - pharmacology Protein Kinase Inhibitors Protein Kinases - metabolism Raffinose - metabolism Rats Rats, Inbred Strains structure Sulfonamides - pharmacology Tritium
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