Reconstitution of thromboxane A2 receptor-stimulated phosphoinositide hydrolysis in isolated platelet membranes : involvement of phosphoinositide-specific phospholipase C-β and GTP-binding protein Gq

Activation of human platelets by the arachidonic acid metabolite thromboxane A2 and the thromboxane A2 mimic U46619 is mediated through phosphoinositide-specific phospholipase C-catalysed hydrolysis of phosphoinositides. We have established conditions to reconstitute U46619-stimulated phosphoinositi...

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Veröffentlicht in:	Biochemical journal 1993-04, Vol.291 (1), p.235-240
Hauptverfasser:	BALDASSARE, J. J, TARVER, A. P, HENDERSON, P. A, MACKIN, W. M, SAHAGAN, B, FISHER, G. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Platelets - metabolism Cell Membrane - metabolism Cell receptors Cell structures and functions Fundamental and applied biological sciences. Psychology GTP-Binding Proteins - physiology Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Guanosine Triphosphate - pharmacology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humans Hydrolysis Isoenzymes - metabolism Kinetics Molecular and cellular biology Phosphatidylinositol Diacylglycerol-Lyase Phosphatidylinositols - metabolism Phosphoric Diester Hydrolases - metabolism Prostaglandin Endoperoxides, Synthetic - pharmacology Receptors, Thromboxane - physiology
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