Autocrine VEGF-B signaling maintains lipid synthesis and mitochondrial fitness to support T cell immune responses

T cells rewire their metabolic activities to meet the demand of immune responses, but how to coordinate the immune response by metabolic regulators in activated T cells is unknown. Here, we identified autocrine VEGF-B as a metabolic regulator to control lipid synthesis and maintain the integrity of...

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Veröffentlicht in:	The Journal of clinical investigation 2024-08, Vol.134 (16), p.1-16
Hauptverfasser:	He, Jianli, Chen, Yalan, Ding, Huihua, Zhou, Jin-An, Xing, Zhengcao, Yang, Xinyu, Fan, Qiuju, Zuo, Yong, Wang, Tianshi, Cheng, Jinke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Apoptosis Autocrine Communication - immunology Autocrine signalling Autoimmune diseases Cardiolipin Cardiolipins - immunology Cardiolipins - metabolism Cell activation Cellular signal transduction Cytokines Fatty acids GA-binding protein Health aspects Humans Immune response Immune response (cell-mediated) Immunological memory Infections Lipids Lymphocyte Activation Lymphocytes Lymphocytes T Membrane lipids Memory cells Metabolism Mice Mitochondria Mitochondria - immunology Mitochondria - metabolism Oxidation Phospholipids Phosphorylation PPAR gamma - genetics PPAR gamma - immunology PPAR gamma - metabolism Proteases Protein binding Proteins Reproductive fitness Signal Transduction - immunology T cell receptors T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism Therapeutic targets Vascular endothelial growth factor Vascular Endothelial Growth Factor B - genetics Vascular Endothelial Growth Factor B - immunology Vascular Endothelial Growth Factor B - metabolism
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