Transcriptional regulation of hydroxyindole O-methyltransferase in the chicken pineal gland : day/night changes and long-term effects of light and darkness
The indolic hormone melatonin is produced by the pineal gland according to a daily rhythm. The terminal step of melatonin synthesis is catalysed by hydroxyindole O-methyltransferase (HIOMT, EC 2.1.1.4). Adaptation to constant light or darkness modifies HIOMT activity and concentration. Using a cDNA...
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| Veröffentlicht in: | Biochemical journal 1993-03, Vol.290 (3), p.661-664 |
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| container_title | Biochemical journal |
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| creator | BERNARD, M GUERLOTTE, J COGNE, M GREVE, P COLLIN, J.-P VOISIN, P |
| description | The indolic hormone melatonin is produced by the pineal gland according to a daily rhythm. The terminal step of melatonin synthesis is catalysed by hydroxyindole O-methyltransferase (HIOMT, EC 2.1.1.4). Adaptation to constant light or darkness modifies HIOMT activity and concentration. Using a cDNA probe encoding HIOMT, we investigated the effect of environmental lighting on HIOMT gene expression in the chicken pineal gland. HIOMT mRNA levels increased by 100% in constant light as compared with constant darkness. In addition, the present study disclosed the existence of a day/night rhythm of HIOMT gene transcription, with 3-fold higher mRNA levels at midday than at midnight. This transcriptional rhythm was not accompanied by day/night changes in HIOMT concentration, probably due to a slow turnover of this protein. Unexpected darkness did not prevent the daytime rise in HIOMT mRNA levels, whereas unexpected light prevented the night-time fall in HIOMT mRNA levels. Together, the data would suggest that the day/night rhythm of HIOMT gene transcription in the chicken pineal gland involves both a response to light and the activity of a biological oscillator. |
| doi_str_mv | 10.1042/bj2900661 |
| format | Article |
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The terminal step of melatonin synthesis is catalysed by hydroxyindole O-methyltransferase (HIOMT, EC 2.1.1.4). Adaptation to constant light or darkness modifies HIOMT activity and concentration. Using a cDNA probe encoding HIOMT, we investigated the effect of environmental lighting on HIOMT gene expression in the chicken pineal gland. HIOMT mRNA levels increased by 100% in constant light as compared with constant darkness. In addition, the present study disclosed the existence of a day/night rhythm of HIOMT gene transcription, with 3-fold higher mRNA levels at midday than at midnight. This transcriptional rhythm was not accompanied by day/night changes in HIOMT concentration, probably due to a slow turnover of this protein. Unexpected darkness did not prevent the daytime rise in HIOMT mRNA levels, whereas unexpected light prevented the night-time fall in HIOMT mRNA levels. Together, the data would suggest that the day/night rhythm of HIOMT gene transcription in the chicken pineal gland involves both a response to light and the activity of a biological oscillator.</description><identifier>ISSN: 0264-6021</identifier><identifier>EISSN: 1470-8728</identifier><identifier>DOI: 10.1042/bj2900661</identifier><identifier>PMID: 8457192</identifier><language>eng</language><publisher>Colchester: Portland Press</publisher><subject>Acetylserotonin O-Methyltransferase - genetics ; Animals ; Biological and medical sciences ; Blotting, Northern ; Cellular Biology ; Chickens ; Chronobiology ; Darkness ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - radiation effects ; Life Sciences ; Light ; Pineal Gland - enzymology ; RNA, Messenger - biosynthesis ; Transcription, Genetic ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Biochemical journal, 1993-03, Vol.290 (3), p.661-664</ispartof><rights>1993 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-3610512ad56bfc675ab37a8be1d6025021431009b8c7de9c07673d66a6c48dea3</citedby><orcidid>0000-0002-8519-4427 ; 0009-0007-2415-6703 ; 0000-0003-0872-2908 ; 0000-0002-4572-1640</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132331/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132331/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4686255$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8457192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04302104$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>BERNARD, M</creatorcontrib><creatorcontrib>GUERLOTTE, J</creatorcontrib><creatorcontrib>COGNE, M</creatorcontrib><creatorcontrib>GREVE, P</creatorcontrib><creatorcontrib>COLLIN, J.-P</creatorcontrib><creatorcontrib>VOISIN, P</creatorcontrib><title>Transcriptional regulation of hydroxyindole O-methyltransferase in the chicken pineal gland : day/night changes and long-term effects of light and darkness</title><title>Biochemical journal</title><addtitle>Biochem J</addtitle><description>The indolic hormone melatonin is produced by the pineal gland according to a daily rhythm. The terminal step of melatonin synthesis is catalysed by hydroxyindole O-methyltransferase (HIOMT, EC 2.1.1.4). Adaptation to constant light or darkness modifies HIOMT activity and concentration. Using a cDNA probe encoding HIOMT, we investigated the effect of environmental lighting on HIOMT gene expression in the chicken pineal gland. HIOMT mRNA levels increased by 100% in constant light as compared with constant darkness. In addition, the present study disclosed the existence of a day/night rhythm of HIOMT gene transcription, with 3-fold higher mRNA levels at midday than at midnight. This transcriptional rhythm was not accompanied by day/night changes in HIOMT concentration, probably due to a slow turnover of this protein. Unexpected darkness did not prevent the daytime rise in HIOMT mRNA levels, whereas unexpected light prevented the night-time fall in HIOMT mRNA levels. Together, the data would suggest that the day/night rhythm of HIOMT gene transcription in the chicken pineal gland involves both a response to light and the activity of a biological oscillator.</description><subject>Acetylserotonin O-Methyltransferase - genetics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cellular Biology</subject><subject>Chickens</subject><subject>Chronobiology</subject><subject>Darkness</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - radiation effects</subject><subject>Life Sciences</subject><subject>Light</subject><subject>Pineal Gland - enzymology</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Transcription, Genetic</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0264-6021</issn><issn>1470-8728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUstu1DAUtRCoDIUFH4DkBUJiEepXnIQFUlVRijRSN2VtOfZN4tZxBjtTkW_hZ3Ha0fDYsLJ8z7nn3GNfhF5T8oESwc7aW9YQIiV9gjZUVKSoK1Y_RRvCpCgkYfQ5epHSLSFUEEFO0Ektyoo2bIN-3kQdkoluN7spaI8j9Huv1wueOjwsNk4_Fhfs5AFfFyPMw-LntaeDqBNgF_A8ADaDM3cQ8M4FyCq918Hij9jq5Sy4fpgzQYceEl7rfgp9MUMcMXQdmDmtVv6BtsJWx7sAKb1EzzrtE7w6nKfo2-Xnm4urYnv95evF-bYwJSdzwSUlJWXalrLtjKxK3fJK1y1Qm6OXOb3glJCmrU1loTGkkhW3UmppRG1B81P06VF3t29HsAZCDujVLrpRx0VN2qm_keAG1U_3ilLOOKdZ4P2jwPBP29X5Vq01Ingeg4j7lfvuYBan73tIsxpdMuDzg8G0T6oqJZcNkf8lUtlQJmj5293EKaUI3XEEStS6Huq4Hpn75s-oR-ZhHzL-9oDrZLTv8kcbl440IWvJypL_Aqt7xIQ</recordid><startdate>19930315</startdate><enddate>19930315</enddate><creator>BERNARD, M</creator><creator>GUERLOTTE, J</creator><creator>COGNE, M</creator><creator>GREVE, P</creator><creator>COLLIN, J.-P</creator><creator>VOISIN, P</creator><general>Portland Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8519-4427</orcidid><orcidid>https://orcid.org/0009-0007-2415-6703</orcidid><orcidid>https://orcid.org/0000-0003-0872-2908</orcidid><orcidid>https://orcid.org/0000-0002-4572-1640</orcidid></search><sort><creationdate>19930315</creationdate><title>Transcriptional regulation of hydroxyindole O-methyltransferase in the chicken pineal gland : day/night changes and long-term effects of light and darkness</title><author>BERNARD, M ; GUERLOTTE, J ; COGNE, M ; GREVE, P ; COLLIN, J.-P ; VOISIN, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-3610512ad56bfc675ab37a8be1d6025021431009b8c7de9c07673d66a6c48dea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acetylserotonin O-Methyltransferase - genetics</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Cellular Biology</topic><topic>Chickens</topic><topic>Chronobiology</topic><topic>Darkness</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - radiation effects</topic><topic>Life Sciences</topic><topic>Light</topic><topic>Pineal Gland - enzymology</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Transcription, Genetic</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BERNARD, M</creatorcontrib><creatorcontrib>GUERLOTTE, J</creatorcontrib><creatorcontrib>COGNE, M</creatorcontrib><creatorcontrib>GREVE, P</creatorcontrib><creatorcontrib>COLLIN, J.-P</creatorcontrib><creatorcontrib>VOISIN, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BERNARD, M</au><au>GUERLOTTE, J</au><au>COGNE, M</au><au>GREVE, P</au><au>COLLIN, J.-P</au><au>VOISIN, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptional regulation of hydroxyindole O-methyltransferase in the chicken pineal gland : day/night changes and long-term effects of light and darkness</atitle><jtitle>Biochemical journal</jtitle><addtitle>Biochem J</addtitle><date>1993-03-15</date><risdate>1993</risdate><volume>290</volume><issue>3</issue><spage>661</spage><epage>664</epage><pages>661-664</pages><issn>0264-6021</issn><eissn>1470-8728</eissn><abstract>The indolic hormone melatonin is produced by the pineal gland according to a daily rhythm. The terminal step of melatonin synthesis is catalysed by hydroxyindole O-methyltransferase (HIOMT, EC 2.1.1.4). Adaptation to constant light or darkness modifies HIOMT activity and concentration. Using a cDNA probe encoding HIOMT, we investigated the effect of environmental lighting on HIOMT gene expression in the chicken pineal gland. HIOMT mRNA levels increased by 100% in constant light as compared with constant darkness. In addition, the present study disclosed the existence of a day/night rhythm of HIOMT gene transcription, with 3-fold higher mRNA levels at midday than at midnight. This transcriptional rhythm was not accompanied by day/night changes in HIOMT concentration, probably due to a slow turnover of this protein. Unexpected darkness did not prevent the daytime rise in HIOMT mRNA levels, whereas unexpected light prevented the night-time fall in HIOMT mRNA levels. 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| ispartof | Biochemical journal, 1993-03, Vol.290 (3), p.661-664 |
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| subjects | Acetylserotonin O-Methyltransferase - genetics Animals Biological and medical sciences Blotting, Northern Cellular Biology Chickens Chronobiology Darkness Fundamental and applied biological sciences. Psychology Gene Expression Regulation - radiation effects Life Sciences Light Pineal Gland - enzymology RNA, Messenger - biosynthesis Transcription, Genetic Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Transcriptional regulation of hydroxyindole O-methyltransferase in the chicken pineal gland : day/night changes and long-term effects of light and darkness |
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