Research Progress of Hydrogel Microneedles in Wound Management
Microneedles are a novel drug delivery system that offers advantages such as safety, painlessness, minimally invasive administration, simplicity of use, and controllable drug delivery. As a type of polymer microneedle with a three-dimensional network structure, hydrogel microneedles (HMNs) possess e...
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| Veröffentlicht in: | ACS biomaterials science & engineering 2024-08, Vol.10 (8), p.4771-4790 |
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| container_title | ACS biomaterials science & engineering |
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| creator | Ji, Ming Zhan, Fangbiao Qiu, Xingan Liu, Hong Liu, Xuezhe Bu, Pengzhen Zhou, Bikun Serda, Maciej Feng, Qian |
| description | Microneedles are a novel drug delivery system that offers advantages such as safety, painlessness, minimally invasive administration, simplicity of use, and controllable drug delivery. As a type of polymer microneedle with a three-dimensional network structure, hydrogel microneedles (HMNs) possess excellent biocompatibility and biodegradability and encapsulate various therapeutic drugs while maintaining drug activity, thus attracting significant attention. Recently, they have been widely employed to promote wound healing and have demonstrated favorable therapeutic effects. Although there are reviews about HMNs, few of them focus on wound management. Herein, we present a comprehensive overview of the design and preparation methods of HMNs, with a particular emphasis on their application status in wound healing, including acute wound healing, infected wound healing, diabetic wound healing, and scarless wound healing. Finally, we examine the advantages and limitations of HMNs in wound management and provide suggestions for future research directions. |
| doi_str_mv | 10.1021/acsbiomaterials.4c00972 |
| format | Article |
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Herein, we present a comprehensive overview of the design and preparation methods of HMNs, with a particular emphasis on their application status in wound healing, including acute wound healing, infected wound healing, diabetic wound healing, and scarless wound healing. Finally, we examine the advantages and limitations of HMNs in wound management and provide suggestions for future research directions.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>38982708</pmid><doi>10.1021/acsbiomaterials.4c00972</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0003-4926-5782</orcidid><orcidid>https://orcid.org/0000-0002-2467-9121</orcidid><orcidid>https://orcid.org/0000-0003-3196-0840</orcidid><orcidid>https://orcid.org/0000-0002-7534-1710</orcidid><oa>free_for_read</oa></addata></record> |
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| source | ACS Publications; MEDLINE |
| subjects | Animals Drug Delivery Systems - instrumentation Humans Hydrogels - chemistry Hydrogels - therapeutic use Needles Review Wound Healing |
| title | Research Progress of Hydrogel Microneedles in Wound Management |
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