Electrochemical detection of FTO with N3-kethoxal labeling and MazF cleavage

N6-Methyladenosine (m6A) is a prevalent modification in eukaryotic mRNAs and is linked to various human cancers. The fat mass and obesity-associated protein (FTO), a key m6A demethylase, is crucial in m6A regulation, affecting many biological processes and diseases. Detecting FTO is vital for clinic...

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Veröffentlicht in:	RSC advances 2024-08, Vol.14 (35), p.25561-25570
Hauptverfasser:	Chen, Chen, Zhao, Mei, Guo, Jingyi, Xia Kuang, Chen, Zilin, Wang, Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Biological properties Biotin Cancer Chemistry Cleavage Electrochemical analysis Obesity Peroxidase Polyethylene glycol
Online-Zugang:	Volltext
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